Showing entry for Ubiquitin carboxyl-terminal hydrolase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005139
Protein NameUbiquitin carboxyl-terminal hydrolase 2
Uniport IdO75604
GeneUSP2
Gene Id9099
DomainUCH
Pfam PF00443  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007049 cell cycle
Biological Process GO:0048512 circadian behavior
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0043153 entrainment of circadian clock by photoperiod
Biological Process GO:0045475 locomotor rhythm
Biological Process GO:0007517 muscle organ development
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045931 positive regulation of mitotic cell cycle
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0050821 protein stabilization
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
molecular function GO:0030332 cyclin binding
molecular function GO:0004197 cysteine-type endopeptidase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004843 thiol-dependent ubiquitin-specific protease activity
molecular function GO:0036459 thiol-dependent ubiquitinyl hydrolase activity
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0005813 centrosome
cellular component GO:0005737 cytoplasm
cellular component GO:0016020 membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-212436 Generic Transcription Pathway
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-392499 Metabolism of proteins
R-HSA-5357786 TNFR1-induced proapoptotic signaling
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5688426 Deubiquitination
R-HSA-5689880 Ub-specific processing proteases
R-HSA-597592 Post-translational protein modification
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73887 Death Receptor Signalling
R-HSA-74160 Gene expression (Transcription)
R-HSA-75893 TNF signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0017665 BXGD001141 Membranous glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0026948 BXGD001952 Mycosis Fungoides Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0079773 BXGD003100 Lymphoma, T-Cell, Cutaneous Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202239 BXGD004087 Uric acid measurement (procedure)
C0334634 BXGD007144 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000194 Sanguinarine 332.33
BXGC0000202 Papaverine 339.39
BXGC0000286 L-DOPA 197.19
BXGC0000323 Isotheaflavin 564.49
BXGC0000430 Gossypol 518.55
BXGC0000436 Glycerol 92.09
BXGC0000481 Xanthoxylin 196.2
BXGC0000514 2,6-Dimethoxy-1,4-benzoquinone 168.15
BXGC0000952 6-Oxocamphor 457.91
BXGC0001417 Isotetrandrine 622.75
BXGC0001613 Trigonelline 137.14
BXGC0001746 Theaflavin 3,3'-digallate 868.7
BXGC0001782 Sennoside B 862.74
BXGC0001881 Chrysophanol 254.24
BXGC0001911 5,7-Dihydroxyisoflavone 254.24
BXGC0001991 Juglone 174.15
BXGC0002018 Morin 302.24
BXGC0002043 Acacetin 284.26
BXGC0002071 Apigenin 270.24
BXGC0002155 Avocadenofuran 248.4
BXGC0002268 Avocadene 1-acetate 328.49
BXGC0002273 Avocadyne 1-acetate 326.47
BXGC0003705 Chloride 35.45
BXGC0003707 Estrogen 268.36
BXGC0005659 Arachidonic acid 304.47
BXGC0005683 Quercetin 302.24
BXGC0005793 Baicalein 270.24
BXGC0006057 (Z)-Resveratrol 228.25
BXGC0006193 Ellagic acid 302.19
BXGC0006306 Myricetin 318.24
BXGC0007259 Avocadyne 284.43
BXGC0007560 alpha-Mangostin 410.46
BXGC0008937 Demethylnobiletin 388.37
BXGC0012352 Chelerythrine 348.12
BXGC0012430 Methyl (1S,15R,17S,18S,19R,20R)-6,18-Dimethoxy-17-(3,4,5-Trimethoxybenzoyl)Oxy-1,3,11,12,14,15,16,17,18,19,20,21-Dodecahydroyohimban-19-Carboxylate 608.27
BXGC0012721 Tetrahydrogambogic Acid 632.33
BXGC0013582 Curcumin 368.13
BXGC0014048 Celastrol 450.28
BXGC0014695 Loratadine 382.14
BXGC0016247 3,5-Dihydroxy-2-Phenylchromen-4-One 254.06
BXGC0016421 punicalin 782.06
BXGC0016886 Papaverine Hydrochloride 339.15
BXGC0018252 Embelin 294.18
BXGC0018287 Erythrosine 835.66
BXGC0018843 Quinalizarin 272.03
BXGC0019117 Tannic Acid 1700.17
BXGC0019164 Raloxifene 473.17
BXGC0020344 Icosa-5,8,11,14-Tetraynoic Acid 296.18
BXGC0022009 (9R)-9-[(9R)-2-Carboxy-4-Hydroxy-10-Oxo-5-[(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracen-9-Yl]-4-Hydroxy-10-Oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracene-2-Carboxylic Acid 862.2
BXGC0022449 Vitamin B2 376.14
BXGC0024132 1H-Indol-5-Ol 133.05
BXGC0024428 3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One 333.15
BXGC0026480 Osajin 404.16
BXGC0027249 Deoxyvasicinone 186.08
BXGC0027421 Paclitaxel 853.33
BXGC0033389 Zinc;1-Oxidopyridine-2-Thione 126
BXGC0037152 (Z)-1-[6-[(3-Acetyl-2,4,6-Trihydroxy-5-Methylphenyl)Methyl]-5,7-Dihydroxy-2,2-Dimethylchromen-8-Yl]-3-Phenylprop-2-En-1-One 516.18
BXGC0037722 Pomiferin 420.16
BXGC0040213 CEPHARANTHINE 606.27
BXGC0040936 Sid26657808 284.07
BXGC0044200 Menadione 172.05
BXGC0046996 Thioguanine 167.03
BXGC0047568 Retinol 286.23
BXGC0047877 Mangiferin 438.08
BXGC0048313 Rosmarinic Acid 360.08
BXGC0049263 4-Methoxydalbergione 254.09
BXGC0050599 tetrandrine 622.3
BXGC0050823 Chebulinic acid 956.11
BXGC0052355 [5,7-Dihydroxy-2-(3,4,5-Trihydroxyphenyl)-3,4-Dihydro-2H-Chromen-3-Yl] 3,4,5-Trihydroxybenzoate 458.08
BXGC0053078 Pinosylvin Methyl Ether 226.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein