Showing entry for Nuclear receptor ROR-gamma


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010846
Protein NameNuclear receptor ROR-gamma
Uniport IdP51449
GeneRORC
Gene Id6097
DomainHormone_recep; zf-C4
Pfam PF00104   PF00105  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04659 Th17 cell differentiation
5. Organismal Systems 5.10 Environmental adaptation hsa04710 Circadian rhythm
6. Human Diseases 6.3 Immune diseases hsa05321 Inflammatory bowel disease (IBD)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060612 adipose tissue development
Biological Process GO:0036315 cellular response to sterol
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0048535 lymph node development
Biological Process GO:0070244 negative regulation of thymocyte apoptotic process
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0048541 Peyer's patch development
Biological Process GO:0042753 positive regulation of circadian rhythm
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045598 regulation of fat cell differentiation
Biological Process GO:0010906 regulation of glucose metabolic process
Biological Process GO:0019218 regulation of steroid metabolic process
Biological Process GO:0060850 regulation of transcription involved in cell fate commitment
Biological Process GO:0072539 T-helper 17 cell differentiation
Biological Process GO:0042093 T-helper cell differentiation
Biological Process GO:0006367 transcription initiation from RNA polymerase II promoter
Biological Process GO:0006805 xenobiotic metabolic process
molecular function GO:0003677 DNA binding
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
molecular function GO:0098531 ligand-activated transcription factor activity
molecular function GO:0004879 nuclear receptor activity
molecular function GO:0008142 oxysterol binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:1990837 sequence-specific double-stranded DNA binding
molecular function GO:0001223 transcription coactivator binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0016604 nuclear body
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System
R-HSA-212436 Generic Transcription Pathway
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-449147 Signaling by Interleukins
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001206 BXGD000033 Acromegaly Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0006840 BXGD000409 Candidiasis Infections
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0008495 BXGD000548 Chorioamnionitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0020625 BXGD001451 Hyponatremia Nutritional and Metabolic Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026918 BXGD001948 Mycobacterium Infections Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0032231 BXGD002339 Pleurisy Infections; Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0086981 BXGD003317 Sicca Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0152066 BXGD003525 Lobomycosis Infections; Skin and Connective Tissue Diseases
C0156369 BXGD003853 Uterine Polyp Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0206180 BXGD004170 Ki-1+ Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0241910 BXGD005123 Autoimmune Chronic Hepatitis Digestive System Diseases; Immune System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0263361 BXGD005292 Psoriasis vulgaris Skin and Connective Tissue Diseases
C0276758 BXGD006448 Fusariosis Infections; Skin and Connective Tissue Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0346302 BXGD007807 Growth Hormone-Secreting Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0376154 BXGD007980 Skin callus Skin and Connective Tissue Diseases
C0392475 BXGD008045 Roberts-SC phocomelia syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0393770 BXGD008142 Delayed Sleep Phase Syndrome Nervous System Diseases; Mental Disorders; Occupational Diseases
C0494410 BXGD009027 Nonorganic Sleep Wake Cycle Disorders Nervous System Diseases; Mental Disorders; Occupational Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0685891 BXGD009824 Congenital hypoplasia of thymus Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751758 BXGD010578 Advanced Sleep Phase Syndrome Nervous System Diseases; Mental Disorders; Occupational Diseases
C0751759 BXGD010579 Non-24 Hour Sleep-Wake Disorder Nervous System Diseases; Mental Disorders; Occupational Diseases
C0751760 BXGD010580 Shift-Work Sleep Disorder Nervous System Diseases; Mental Disorders; Occupational Diseases
C0877792 BXGD011359 Sleep Disorders, Circadian Rhythm Nervous System Diseases; Mental Disorders; Occupational Diseases
C1275122 BXGD012060 Familial multiple trichoepitheliomata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C1275592 BXGD012088 Funisitis (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1334008 BXGD012675 High Grade Sarcoma
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1535939 BXGD013323 Pneumocystis jiroveci pneumonia Infections; Respiratory Tract Diseases
C1856689 BXGD015630 FRIEDREICH ATAXIA 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1960272 BXGD016654 Latent autoimmune diabetes mellitus in adult Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C2362324 BXGD017091 Pediatric Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C3695127 BXGD019344 Astrocytoma of brain Neoplasms; Nervous System Diseases
C3714948 BXGD019440 PACHYONYCHIA CONGENITA 3
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3899278 BXGD020078 Early Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C4048329 BXGD021904 Immunosuppression
C4082937 BXGD022095 Necrotizing enterocolitis in fetus OR newborn Digestive System Diseases
C4225266 BXGD022200 IMMUNODEFICIENCY 42
C4524092 BXGD023092 Chronic rhinosinusitis with nasal polyps
C4721555 BXGD023755 Autoimmune hepatitis Digestive System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0000204 Theophylline 180.16
BXGC0000340 Kaempferol 286.24
BXGC0000433 Triacetin 218.2
BXGC0000434 Ethanol 46.07
BXGC0000436 Glycerol 92.09
BXGC0000439 Chloroform 119.38
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000473 2-Methylbenzaldehyde 120.15
BXGC0000478 2,4,6-Tribromophenol 330.8
BXGC0000530 Hydroquinone 110.11
BXGC0000531 Mequinol 124.14
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000539 Anthranilic acid 137.14
BXGC0000563 1H-Indole-3-methanol 147.17
BXGC0000573 Dantron 240.21
BXGC0000634 Benzyl salicylate 228.24
BXGC0000661 Cellulase 288.42
BXGC0000696 Tartaric acid 150.09
BXGC0001002 1,2-Benzenediol 110.11
BXGC0001325 Progesterone 314.46
BXGC0001767 (E)-Resveratrol 228.25
BXGC0001789 Silibinin 482.44
BXGC0001881 Chrysophanol 254.24
BXGC0001899 Daidzein 254.24
BXGC0002014 Dihydromethysticin 276.28
BXGC0002071 Apigenin 270.24
BXGC0002248 Dodecanoic acid 200.32
BXGC0002396 Ethoxyacetic acid 104.1
BXGC0002498 Butanal 72.11
BXGC0002588 Magnesium 24.31
BXGC0002796 Nicotine 162.23
BXGC0002911 Fur-2-aldehyde 96.08
BXGC0002916 Melatonin 232.28
BXGC0002971 alpha-Lipoic acid 206.33
BXGC0003054 N-Ethylaniline 121.18
BXGC0003131 N,N-Dimethylformamide 73.09
BXGC0003188 Pinene 136.24
BXGC0003456 1,4-Benzoquinone 108.09
BXGC0003472 1,3-Dimethylbenzene 106.17
BXGC0003610 5-Hydroxy-L-tryptophan 220.22
BXGC0003705 Chloride 35.45
BXGC0003707 Estrogen 268.36
BXGC0003776 Flavones 222.24
BXGC0004119 Synepherine 167.21
BXGC0004147 Heptanoic acid 130.18
BXGC0004253 Phenoxyacetic acid 152.15
BXGC0004261 Propylene glycol 76.09
BXGC0004559 1,3-Benzenediol 110.11
BXGC0004569 Benzophenone 182.22
BXGC0004576 2-tert-Butyl-1,4-benzenediol 166.22
BXGC0004580 Carbanilide 212.25
BXGC0004587 (E)-3-Phenyl-2-propenal 132.16
BXGC0004591 4-Methylphenol 108.14
BXGC0004594 Dibenzyl ether 198.26
BXGC0004753 Phthalic acid 166.13
BXGC0004951 1-Methylnaphthalene 142.2
BXGC0004955 N-Phenyl-2-naphthylamine 219.28
BXGC0004965 Rhein 284.22
BXGC0004969 1,4,5-Naphthalenetriol 176.17
BXGC0005254 Dibutyl phthalate 278.34
BXGC0005668 2-Methoxyphenol 124.14
BXGC0005762 Dimethyl succinate 146.14
BXGC0005771 Decanoic acid 172.26
BXGC0005832 Acetophenone 120.15
BXGC0005982 Curcumin 368.38
BXGC0005995 Imidazole 68.08
BXGC0006079 Yangonin 258.27
BXGC0006115 Xanthotoxin 216.19
BXGC0006211 5,6-Dihydro-5-hydroxy-6-methyl-2H-pyran-2-one 228.24
BXGC0006300 5-Hydroxymethyl-2-furancarboxaldehyde 126.11
BXGC0006301 2-Methylfuran 82.1
BXGC0007029 Emodin 270.24
BXGC0008101 Sodium nitrite 69
BXGC0009308 Carvyl acetate 194.27
BXGC0011084 Pentanenitrile 83.13
BXGC0012228 Vitamin D 384.64
BXGC0012243 Ukonan D 151.16
BXGC0015594 4-Nonylphenol 220.18
BXGC0015879 Chlorhexidine 504.2
BXGC0016124 Isosafrole 162.07
BXGC0016691 3,7,11,15-Tetramethylhexadec-1-En-3-Ol 296.31
BXGC0016747 Camphor 152.12
BXGC0016980 1,2,3,4,4A,5,6,7,8,8A-Decahydronaphthalene 138.14
BXGC0017100 1,2-Dichlorobenzene 145.97
BXGC0017757 Androstenedione 286.19
BXGC0018421 2,4-Hexadienal 96.06
BXGC0020800 Testosterone 288.21
BXGC0020884 Thiourea 76.01
BXGC0021134 (S)(+)Carvone 150.1
BXGC0021924 Benzo[F]Quinoline 179.07
BXGC0022544 Digoxin 780.43
BXGC0024988 Nifedipine 346.12
BXGC0025325 Methysticin 274.08
BXGC0026698 2-Hydroxyethyl Prop-2-Enoate 116.05
BXGC0027480 (2E,4E)-Deca-2,4-Dienal 152.12
BXGC0028696 Cichoric Acid 474.08
BXGC0029253 Desmosterol 384.34
BXGC0029399 3-(2-Ethylhexoxy)Propan-1-Amine 187.19
BXGC0029864 2-pentenenitrile 81.06
BXGC0030138 Colchicine 399.17
BXGC0030553 3-(4-Tert-Butylphenyl)-2-Methylpropanal 204.15
BXGC0031040 Atrazine 215.09
BXGC0032002 rockogenin 432.32
BXGC0032459 Sumiki's Acid 142.03
BXGC0033300 Carbazole 167.07
BXGC0033776 Cycloheximide 281.16
BXGC0034035 Capsaicin 305.2
BXGC0034208 3-Aminophenol 109.05
BXGC0034894 Oleic Acid 282.26
BXGC0035101 Guggulsterone 312.21
BXGC0036596 Ursonic Acid 454.34
BXGC0037407 Lithocholic Acid 376.3
BXGC0037666 Retinal 284.21
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0037718 Ethacrynic Acid 302.01
BXGC0038316 Cholesterol 386.35
BXGC0038322 Kavain 230.09
BXGC0038329 iodoform 393.72
BXGC0038963 Dichlorvos 219.95
BXGC0039023 3-chlorobenzoic acid 156
BXGC0039046 Digitonin 1228.57
BXGC0041054 Bis(2-Ethylhexyl) Phthalate 390.28
BXGC0041418 Bis(2-Ethylhexyl) Hexanedioate 370.31
BXGC0041560 Thiram 239.99
BXGC0041894 Questiomycin B 109.05
BXGC0042127 Oxyquinoline 145.05
BXGC0042336 7-Amino-4-Hydroxynaphthalene-2-Sulfonic Acid 239.03
BXGC0043639 1-Tert-Butyl-2-Methoxy-4-Methyl-3,5-Dinitrobenzene 268.11
BXGC0043841 Ganoderone A 454.34
BXGC0044450 Phthalic Anhydride 148.02
BXGC0047088 Ursolic Acid 456.36
BXGC0047568 Retinol 286.23
BXGC0049633 4-Aminophenol 109.05
BXGC0051342 Valerenic Acid 234.16
BXGC0051728 2-Methylpropyl Nitrite 103.06
BXGC0052374 Reserpine 608.27
BXGC0052878 Bisphenol A 228.12
BXGC0053544 Actein 676.38
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein