Showing entry for Taxifolin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0002029
Compound NameTaxifolin
Structure
FormulaC15H12O7
InchiKeyCXQWRCVTCMQVQX-LSDHHAIUSA-N
SMILESO[C@@H]1[C@H](OC2=C(C(O)=CC(O)=C2)C1=O)C1=CC=C(O)C(O)=C1
InchiInChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1
IUPAC(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-4-one
Molecular Weight304.25
Pubchem Id439533
Chembl IdCHEMBL66
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB DQH
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q96323 BXGT019598 Leucoanthocyanidin dioxygenase reviewed LDOX - - - - -
P93799 BXGT012122 Dihydroflavonol 4-reductase unreviewed dfr1 - - - - -
P16559 BXGT008242 Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN reviewed tcmN - - - - -
Binding DB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
CHEMBL CHEMBL66
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit reviewed Kinase KIT IC50 '=' 15700 nM
P56817 BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 IC50 '=' 30000 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 79432 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 15848 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 10000 nM
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 35481 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 35481 nM
Q04759 BXGT012781 Protein kinase C theta type reviewed Kinase PRKCQ IC50 '>' 100000 nM
Q15139 BXGT013546 Serine/threonine-protein kinase D1 reviewed Kinase PRKD1 IC50 '>' 100000 nM
P24723 BXGT008989 Protein kinase C eta type reviewed Kinase PRKCH IC50 '>' 100000 nM
Q02156 BXGT012639 Protein kinase C epsilon type reviewed Kinase PRKCE IC50 '>' 100000 nM
Q05513 BXGT012820 Protein kinase C zeta type reviewed Kinase PRKCZ IC50 '>' 100000 nM
P05771 BXGT006384 Protein kinase C beta type reviewed Kinase PRKCB IC50 '>' 100000 nM
Q05655 BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD IC50 '>' 100000 nM
P05129 BXGT006322 Protein kinase C gamma type reviewed Kinase PRKCG IC50 '>' 100000 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 '>' 100000 nM
P41743 BXGT010270 Protein kinase C iota type reviewed Kinase PRKCI IC50 '>' 100000 nM
O94806 BXGT005335 Serine/threonine-protein kinase D3 reviewed Kinase PRKD3 IC50 '>' 100000 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC Potency '=' 56234 nM
P56817 BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 IC50 '=' 35000 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 28183 nM
Q04759 BXGT012781 Protein kinase C theta type reviewed Kinase PRKCQ Phorbol displacement - - -
Q15139 BXGT013546 Serine/threonine-protein kinase D1 reviewed Kinase PRKD1 Phorbol displacement - - -
P24723 BXGT008989 Protein kinase C eta type reviewed Kinase PRKCH Phorbol displacement - - -
Q02156 BXGT012639 Protein kinase C epsilon type reviewed Kinase PRKCE Phorbol displacement - - -
P05771 BXGT006384 Protein kinase C beta type reviewed Kinase PRKCB Phorbol displacement - - -
Q05655 BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD Phorbol displacement - - -
P05129 BXGT006322 Protein kinase C gamma type reviewed Kinase PRKCG Phorbol displacement - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Phorbol displacement - - -
O94806 BXGT005335 Serine/threonine-protein kinase D3 reviewed Kinase PRKD3 Phorbol displacement - - -
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Activity - - -
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 31622 nM
P03070 BXGT006016 Large T antigen reviewed - IC50 - 31960 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 3162 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 19952 nM
Q962Y6 BXGT019597 Thioredoxin glutathione reductase unreviewed - TGR Potency '=' 35481 nM
Q72547 BXGT016709 Reverse transcriptase/RNaseH unreviewed - pol Inhibition '=' 22 %
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 3548 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 0 %
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 89125 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 10000 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 33000 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 79432 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 631 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 79432 nM
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit reviewed Kinase KIT Activity '=' 15 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 17 %
O60218 BXGT004858 Aldo-keto reductase family 1 member B10 reviewed Enzyme AKR1B10 Inhibition - - -
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit reviewed Kinase KIT IC50 '=' 21900 nM
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit reviewed Kinase KIT Activity '=' 12 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00038 Tea Camellia sinensis Teas
BXGF00102 Mexican oregano Lippia graveolens Herbs and Spices
BXGF00124 Common oregano Origanum vulgare Herbs and Spices
BXGF00146 Sour cherry Prunus cerasus Fruits
BXGF00183 Common thyme Thymus vulgaris Herbs and Spices
BXGF00199 Gram bean Vigna mungo Pulses
BXGF00503 Rowal Pangium edule Herbs and Spices
BXGF00881 Oreoherzogia fallax Oreoherzogia fallax Medicinal Plant
BXGF00909 Ichthyothere terminalis Ichthyothere terminalis Others
BXGF00966 Tristania conferta Tristania conferta Others
BXGF00972 Plectranthus myrianthus Plectranthus myrianthus Others
BXGF01024 Pentaclethra macrophylla Pentaclethra macrophylla Medicinal Plant
BXGF01047 Piper taboganum Piper taboganum Others
BXGF01051 Callicarpa japonica Callicarpa japonica Medicinal Plant
BXGF01061 Avrainvillea longicaulis Avrainvillea longicaulis Others
BXGF01085 Veronica polita Veronica polita Medicinal Plant
BXGF01164 Polygala reinii Polygala reinii Medicinal Plant
BXGF01183 Glycosmis macrophylla Glycosmis macrophylla Others
BXGF01222 Ocimum tenuiflorum Ocimum tenuiflorum Medicinal Plant
BXGF01253 Stephania zippeliana Stephania zippeliana Others
BXGF01286 Artemisia incanescens Artemisia incanescens Others
BXGF01324 Albizia julibrissin Albizia julibrissin Medicinal Plant
BXGF01329 Eucalyptus apodophylla Eucalyptus apodophylla Medicinal Plant
BXGF01332 Perriera orientalis Perriera orientalis Others
BXGF01341 Trachelospermum jasminoides Trachelospermum jasminoides Medicinal Plant
BXGF01374 Balanops australiana Balanops australiana Others
BXGF01416 Hypericum polyanthemum Hypericum polyanthemum Others
BXGF01418 Distephanus angulifolius Distephanus angulifolius Others
BXGF01480 Periploca sepium Periploca sepium Medicinal Plant
BXGF01506 Thymus quinquecostatus Thymus quinquecostatus Medicinal Plant
BXGF01548 Campylotropis hirtella Campylotropis hirtella Medicinal Plant
BXGF01562 Strychnos tomentosa Strychnos tomentosa Others
BXGF01599 Helichrysum cephaloideum Helichrysum cephaloideum Medicinal Plant
BXGF01652 Ichthyothere latifolia Ichthyothere latifolia Others
BXGF01676 Scrophularia umbrosa Scrophularia umbrosa Medicinal Plant
BXGF01684 Hemionitis japonica Hemionitis japonica Others
BXGF01721 Humulus lupulus Humulus lupulus Medicinal Plant
BXGF01722 Microglossa pyrrhopappa Microglossa pyrrhopappa Others
BXGF01742 Solanum sublobatum Solanum sublobatum Others
BXGF01747 Adenocarpus foliolosus Adenocarpus foliolosus Others
BXGF01783 Ipomoea reptans Ipomoea reptans Medicinal Plant
BXGF01793 Sedum obtuso-lineare Sedum obtuso-lineare Others
BXGF01828 Retama duriaei Retama duriaei Others
BXGF01830 Swertia pseudochinensis Swertia pseudochinensis Medicinal Plant
BXGF01862 Rubia schumanniana Rubia schumanniana Others
BXGF01890 Trollius chinensis Trollius chinensis Medicinal Plant
BXGF01910 Trachelospermum asiaticum Trachelospermum asiaticum Medicinal Plant
BXGF02053 Hypericum balearicum Hypericum balearicum Others
BXGF02119 Larix laricina Larix laricina Medicinal Plant
BXGF02199 Bryum argenteum Bryum argenteum Medicinal Plant
BXGF02323 Dalbergia hupeana Dalbergia hupeana Medicinal Plant
BXGF02341 Euphorbia amygdaloides Euphorbia amygdaloides Medicinal Plant
BXGF02380 Entada phaseoloides Entada phaseoloides Medicinal Plant
BXGF02421 Hesperis matronalis Hesperis matronalis Medicinal Plant
BXGF02449 Jatropha macrorhiza Jatropha macrorhiza Others
BXGF02505 Pinus sylvestris Pinus sylvestris Medicinal Plant
BXGF02523 Andira inermis Andira inermis Medicinal Plant
BXGF02528 Cirsium oligophyllum Cirsium oligophyllum Medicinal Plant
BXGF02540 Jackiella javanica Jackiella javanica Medicinal Plant
BXGF02551 Inula britannica Inula britannica Medicinal Plant
BXGF02587 Rhus vulgaris Rhus vulgaris Human Edible Plant
BXGF02604 Agrimonia pilosa Agrimonia pilosa Medicinal Plant
BXGF02610 Cladrastis platycarpa Cladrastis platycarpa Others
BXGF02633 Breonia chinensis Breonia chinensis Medicinal Plant
BXGF02646 Eremanthus seidelii Eremanthus seidelii Others
BXGF02732 Senecio adenophyllus Senecio adenophyllus Others
BXGF02768 Lilium umbellatum Lilium umbellatum Others
BXGF02784 Artemisia rehan Artemisia rehan Others
BXGF02802 Araiostegiella perdurans Araiostegiella perdurans Others
BXGF02807 Elephantopus hirtiflorus Elephantopus hirtiflorus Others
BXGF02828 Nematolepis phebalioides Nematolepis phebalioides Others
BXGF02839 Solidago flexicaulis Solidago flexicaulis Human Edible Plant
BXGF02854 Ligularia cymbulifera Ligularia cymbulifera Others
BXGF02877 Coprosma areolata Coprosma areolata Medicinal Plant
BXGF02907 Oreopteris quelpaertensis Oreopteris quelpaertensis Others
BXGF02948 Viguiera linearis Viguiera linearis Others
BXGF03094 Menispermum dauricum Menispermum dauricum Medicinal Plant
BXGF03184 Sasa paniculata Sasa paniculata Others
BXGF03189 Rhododendron dauricum Rhododendron dauricum Medicinal Plant
BXGF03223 Sedum forsteri Sedum forsteri Medicinal Plant
BXGF03247 Anastatica hierochuntica Anastatica hierochuntica Medicinal Plant
BXGF03258 Populus angustifolia Populus angustifolia Medicinal Plant
BXGF03313 Magnolia montana Magnolia montana Medicinal Plant
BXGF03392 Paulownia tomentosa Paulownia tomentosa Medicinal Plant
BXGF03413 Lasiosiphon kraussianus Lasiosiphon kraussianus Others
BXGF03438 Clethra macrophylla Clethra macrophylla Others
BXGF03443 Morinda morindoides Morinda morindoides Human Edible Plant
BXGF03476 Hylocomium splendens Hylocomium splendens Others
BXGF03504 Sterculia foetida Sterculia foetida Medicinal Plant
BXGF03518 Mentha cardiaca Mentha cardiaca Others
BXGF03546 Pseudofumaria lutea Pseudofumaria lutea Others
BXGF03610 Bistorta officinalis Bistorta officinalis Medicinal Plant
BXGF03637 Rhodiola semenovii Rhodiola semenovii Others
BXGF03732 Grazielia serrata Grazielia serrata Others
BXGF03754 Sapindus emarginatus Sapindus emarginatus Medicinal Plant
BXGF03763 Millettia laurentii Millettia laurentii Medicinal Plant
BXGF03765 Alcea rosea Alcea rosea Medicinal Plant
BXGF03973 Cyperus papyrus Cyperus papyrus Medicinal Plant
BXGF03982 Maytenus retusa Maytenus retusa Others
BXGF04033 Sabal blackburniana Sabal blackburniana Others
BXGF04053 Smilax china Smilax china Medicinal Plant
BXGF04062 Spatholobus suberectus Spatholobus suberectus Medicinal Plant
BXGF04080 Persicaria orientalis Persicaria orientalis Medicinal Plant
BXGF04224 Bistorta manshuriensis Bistorta manshuriensis Others
BXGF04255 Gmelina asiatica Gmelina asiatica Medicinal Plant
BXGF04263 Glycine soja Glycine soja Medicinal Plant
BXGF04301 Dorstenia dinklagei Dorstenia dinklagei Others
BXGF04302 Lachnophyllum gossypinum Lachnophyllum gossypinum Others
BXGF04325 Baphia bancoensis Baphia bancoensis Others
BXGF04328 Croton zehntneri Croton zehntneri Others
BXGF04349 Monodora tenuifolia Monodora tenuifolia Human Edible Plant
BXGF04451 Pteris cretica var. nervosa Pteris cretica var. nervosa Garden Plant
BXGF04607 Morus alba Morus alba Medicinal Plant
BXGF04659 Phyllanthus emblica Phyllanthus emblica Medicinal Plant
BXGF04772 Sapium haematospermum Sapium haematospermum Medicinal Plant
BXGF04801 Anthoxanthum nitens Anthoxanthum nitens Medicinal Plant
BXGF04896 Kokoona reflexa Kokoona reflexa Others
BXGF04910 Spinulum annotinum Spinulum annotinum Medicinal Plant
BXGF04944 Sabal causiarum Sabal causiarum Others
BXGF04953 Polygonum aviculare Polygonum aviculare Medicinal Plant
BXGF04965 Dimorphotheca aurantiaca Dimorphotheca aurantiaca Others
BXGF05083 Viguiera decurrens Viguiera decurrens Medicinal Plant
BXGF05128 Pittocaulon velatum Pittocaulon velatum Others
BXGF05145 Sideritis brevibracteata Sideritis brevibracteata Human Edible Plant
BXGF05170 Crotalaria candicans Crotalaria candicans Others
BXGF05184 Maesa ramentacea Maesa ramentacea Medicinal Plant
BXGF05242 Euphorbia cornigera Euphorbia cornigera Others
BXGF05285 Aglaia formosana Aglaia formosana Others
BXGF05368 Salvia yosgadensis Salvia yosgadensis Others
BXGF05385 Eria japonica Eria japonica Others
BXGF05427 Salvia sessei Salvia sessei Others
BXGF05428 Sideroxylon cubense Sideroxylon cubense Others
BXGF05452 Othonna dentata Othonna dentata Others
BXGF05466 Juniperus drupacea Juniperus drupacea Medicinal Plant
BXGF05583 Acacia mearnsii Acacia mearnsii Medicinal Plant
BXGF05615 Ceropegia dichotoma Ceropegia dichotoma Garden Plant
BXGF05654 Pinus strobus Pinus strobus Medicinal Plant
BXGF05676 Betula exilis Betula exilis Others
BXGF05684 Neorautanenia ficifolia Neorautanenia ficifolia Others
BXGF05708 Ononis spinosa Ononis spinosa Medicinal Plant
BXGF05728 Persicaria perfoliata Persicaria perfoliata Medicinal Plant
BXGF05730 Alpinia blepharocalyx Alpinia blepharocalyx Medicinal Plant
BXGF05764 Eucalyptus jenseni Eucalyptus jenseni Others
BXGF05787 Smilax glabra Smilax glabra Medicinal Plant
BXGF05861 Chromolaena arnottiana Chromolaena arnottiana Others
BXGF05869 Salacia lehmbachii Salacia lehmbachii Medicinal Plant
BXGF05903 Crinum moorei Crinum moorei Others
BXGF05913 Eucalyptus globulus subsp. bicostata Eucalyptus globulus subsp. bicostata Medicinal Plant
BXGF05954 Pluchea odorata Pluchea odorata Others
BXGF06033 Euonymus tingens Euonymus tingens Medicinal Plant
BXGF06064 Strychnos erichsonii Strychnos erichsonii Human Edible Plant
BXGF06069 Dendrobium loddigesii Dendrobium loddigesii Medicinal Plant
BXGF06119 Gypsophila perfoliata Gypsophila perfoliata Others
BXGF06131 Fagus grandifolia Fagus grandifolia Medicinal Plant
BXGF06156 Inula japonica Inula japonica Medicinal Plant
BXGF06195 Pterocaulon virgatum Pterocaulon virgatum Medicinal Plant
BXGF06204 Mitragyna inermis Mitragyna inermis Medicinal Plant
BXGF06241 Vernonia cistifolia Vernonia cistifolia Others
BXGF06274 Sonneratia caseolaris Sonneratia caseolaris Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease