Showing entry for Arachidonic acid


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0005659
Compound NameArachidonic acid
Structure
FormulaC20H32O2
InchiKeyYZXBAPSDXZZRGB-DOFZRALJSA-N
SMILESCCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
InchiInChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-15-
IUPAC(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid
Molecular Weight304.47
Pubchem Id444899
Chembl IdCHEMBL15594
Targets of Information Source
DrugBank DB04557
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P29498 BXGT009356 14 kDa fatty acid-binding protein reviewed - - experimental -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 experimental -
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha reviewed Nuclear receptor PPARA experimental -
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 experimental ligand
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA experimental -
PDB ACD
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P04117 BXGT006149 Fatty acid-binding protein, adipocyte reviewed Fabp4 - - - 4400 -
Q05769 BXGT012834 Prostaglandin G/H synthase 2 reviewed Ptgs2 - - - - -
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - - - - -
P02768 BXGT005955 Serum albumin reviewed ALB Transporter - - - -
P29498 BXGT009356 14 kDa fatty acid-binding protein reviewed - - - 10 -
Q9I9P7 BXGT020787 Extracellular fatty acid-binding protein reviewed - - - - -
O16025 BXGT004194 Allene oxide synthase-lipoxygenase protein reviewed - - - - -
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed ALOX5 Enzyme - - - -
D8LJ35 BXGT003020 Polyketide Synthase III unreviewed PKS - - - - -
P02791 BXGT005965 Ferritin light chain reviewed FTL - - - - -
Q13822 BXGT013396 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 reviewed ENPP2 Enzyme - - - -
A0A093VKV7 BXGT000096 Envelope glycoprotein unreviewed GQ26_0022220 - - - 2300 -
A8HBN5 BXGT001688 Cell wall antigen unreviewed MP1 - - - - -
Q4WZA5 BXGT014929 Uncharacterized protein unreviewed AFUA_2G17630 - - - - -
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed PPARG Nuclear receptor - - - -
Q1HRL7 BXGT013800 AAEL005772-PA unreviewed 5567053 - - - - -
Binding DB 22319
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT009490 Thromboxane A2 receptor reviewed Tbxa2r >10000 - - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - - 8070 -
reviewed BXGT012839 Fatty acid-binding protein 5 reviewed Fabp5 - - 42.1 -
reviewed BXGT012590 Fatty acid-binding protein 5 reviewed FABP5 2590 - - -
reviewed BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 - 1072 - -
reviewed BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 - 603 - -
reviewed BXGT005645 Trypsin reviewed - - >200000 - -
reviewed BXGT007950 Tissue factor reviewed Receptor F3 - 105000 - -
reviewed BXGT021795 Cytosolic phospholipase A2 gamma reviewed Enzyme PLA2G4C - >100000 - -
reviewed BXGT007717 Aromatase reviewed Enzyme CYP19A1 - 28200 - -
reviewed BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Cacna1c - 8500 - -
reviewed BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Cacna1c - 5800 - -
reviewed BXGT008079 Fatty acid-binding protein, adipocyte reviewed FABP4 - - 180 -
reviewed BXGT013681 Lanosterol 14-alpha demethylase reviewed Enzyme CYP51A1 - >200000 - -
reviewed BXGT003934 Fatty-acid amide hydrolase 1 reviewed FAAH - >100000 - -
reviewed BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 330 - - -
reviewed BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 820 - - -
CHEMBL CHEMBL15594
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 19952 nM
Q9HC16 BXGT020525 DNA dC->dU-editing enzyme APOBEC-3G reviewed Enzyme APOBEC3G Potency - 33498 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 IC50 '=' 602 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 22387 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '=' 5800 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 22387 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Ki '=' 330 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 14125 nM
P13726 BXGT007950 Tissue factor reviewed Receptor F3 IC50 '=' 105000 nM
P08709 BXGT006818 Coagulation factor VII reviewed Enzyme F7 IC50 '=' 105000 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 12589 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD IC50 '=' 3100 nM
P11511 BXGT007717 Aromatase reviewed Enzyme CYP19A1 Activity '=' 147 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 18356 nM
O00519 BXGT003934 Fatty-acid amide hydrolase 1 reviewed - FAAH IC50 '>' 100000 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 31622 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '=' 8500 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 44668 nM
O75604 BXGT005139 Ubiquitin carboxyl-terminal hydrolase 2 reviewed Enzyme USP2 Potency '=' 3162 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 31622 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 7943 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 316 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 15848 nM
P15090 BXGT008079 Fatty acid-binding protein, adipocyte reviewed - FABP4 Kd '=' 180 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 17782 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 2818 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 7943 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 50118 nM
Q16850 BXGT013681 Lanosterol 14-alpha demethylase reviewed Enzyme CYP51A1 IC50 '>' 200000 nM
Q9Y468 BXGT022270 Lethal(3)malignant brain tumor-like protein 1 reviewed Epigenetic regulator L3MBTL1 Potency '=' 39810 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 2238 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 28183 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 79 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 39810 nM
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 Km '=' 9700 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ka '=' 0 10'4/M
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 23715 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 15848 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 15848 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 10000 nM
Q9UP65 BXGT021795 Cytosolic phospholipase A2 gamma reviewed Enzyme PLA2G4C IC50 '>' 100000 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 25118 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 63095 nM
P11511 BXGT007717 Aromatase reviewed Enzyme CYP19A1 IC50 '=' 28200 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29855 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 39810 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 31622 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 31622 nM
P00761 BXGT005645 Trypsin reviewed - IC50 '>' 200000 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Km '=' 1000 nM
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 50118 nM
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha reviewed Nuclear receptor PPARA IC50 '=' 1200 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 25118 nM
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Potency '=' 31622 nM
P11511 BXGT007717 Aromatase reviewed Enzyme CYP19A1 Activity '=' 11 %
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 23 %
Q962Y6 BXGT019597 Thioredoxin glutathione reductase unreviewed - TGR Potency '=' 17782 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 28183 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 17782 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 17782 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ka '=' 0 10'4/M
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 39810 nM
O62664 BXGT004924 Prostaglandin G/H synthase 1 reviewed - PTGS1 Km '=' 8800 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 7943 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 56234 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 15848 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 5 %
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 12589 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 31622 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 11582 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 5623 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 3981 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 35481 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 15848 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 12589 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG IC50 '=' 1600 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 1995 nM
Q00910 BXGT012551 Solute carrier organic anion transporter family member 2A1 reviewed - Slco2a1 Km '=' 96000 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 IC50 '=' 1071 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Ki '=' 820 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 31622 nM
Q9WUD2 BXGT021939 Transient receptor potential cation channel subfamily V member 2 reviewed - Trpv2 IC50 '>' 10000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00032 Brussel sprouts Brassica oleracea var. gemmifera Vegetables
BXGF00068 Turmeric Curcuma longa Herbs and Spices
BXGF00072 Wild carrot Daucus carota Vegetables
BXGF00079 Common buckwheat Fagopyrum esculentum Cereals and cereal products
BXGF00085 Soy bean Glycine max Soy
BXGF00130 Avocado Persea americana Vegetables
BXGF00142 Purslane Portulaca oleracea Herbs and Spices
BXGF00149 Peach Prunus persica Fruits
BXGF00170 Sesame Sesamum orientale Herbs and Spices
BXGF00230 Carrot Daucus carota ssp. sativus Vegetables
BXGF00274 Atlantic wolffish Anarhichas lupus Aquatic foods
BXGF00315 Cottonseed Gossypium Herbs and Spices
BXGF00415 Coho salmon Oncorhynchus kisutch Aquatic foods
BXGF00454 Salmonidae (Salmon, Trout) Salmonidae Aquatic foods
BXGF00455 Cattle (Beef, Veal) Bos taurus Animal foods
BXGF00474 Gadus (Common cod) Gadus Aquatic foods
BXGF00475 Atlantic halibut Hippoglossus hippoglossus Aquatic foods
BXGF00478 Clupeinae (Herring, Sardine, Sprat) Clupeinae Aquatic foods
BXGF00486 Rabbit Leporidae Animal foods
BXGF00494 Domestic pig (Piglet, Pork) Sus scrofa domestica Animal foods
BXGF00514 Ostrich fern Matteuccia struthiopteris Vegetables
BXGF00519 Wheat Triticum Cereals and cereal products
BXGF00524 Anchovy Engraulidae Aquatic foods
BXGF00531 Crab Brachyura Aquatic foods
BXGF00534 Anatidae (Duck, Goose, Swan) Anatidae Animal foods
BXGF00537 Garfish Belone belone Aquatic foods
BXGF00541 Lemon sole Microstomus kitt Aquatic foods
BXGF00542 Clawed lobster Nephropidae Aquatic foods
BXGF00545 Marine mussel Mytilidae Aquatic foods
BXGF00547 Norway lobster Nephrops norvegicus Aquatic foods
BXGF00550 True oyster Ostreidae Aquatic foods
BXGF00556 Pacific ocean perch Sebastes alutus Aquatic foods
BXGF00562 True sole Soleidae Aquatic foods
BXGF00563 Catfish Siluriformes Aquatic foods
BXGF00576 Eggs Eggs
BXGF00597 Crisp bread Cereals and cereal products
BXGF00612 Pate Dishes
BXGF00614 Meat bouillon Baking goods
BXGF00620 Gelatin Baking goods
BXGF00660 Hamburger Dishes
BXGF00700 Semolina Cereals and cereal products
BXGF00710 Other sandwich Dishes
BXGF00802 Soft-necked garlic Allium sativum L. var. sativum Herbs and Spices
BXGF00937 Sloanea zuliaensis Sloanea zuliaensis Others
BXGF01014 Humboldtia laurifolia Humboldtia laurifolia Others
BXGF01226 Agrimonia eupatoria Agrimonia eupatoria Medicinal Plant
BXGF01382 Zingiber aromaticum Zingiber aromaticum Medicinal Plant
BXGF01475 Tillandsia fragrans Tillandsia fragrans Others
BXGF01574 Alstonia lanceolifera Alstonia lanceolifera Others
BXGF01617 Campanula medium Campanula medium Medicinal Plant
BXGF01647 Pieris formosa Pieris formosa Medicinal Plant
BXGF01728 Selaginella uncinata Selaginella uncinata Medicinal Plant
BXGF01765 Teucrium montanum Teucrium montanum Medicinal Plant
BXGF01839 Alluaudia humbertii Alluaudia humbertii Others
BXGF01865 Rhabdodendron amazonicum Rhabdodendron amazonicum Others
BXGF01928 Artemisia caerulescens Artemisia caerulescens Others
BXGF01953 Echinops spinosissimus Echinops spinosissimus Medicinal Plant
BXGF02004 Magnolia salicifolia Magnolia salicifolia Medicinal Plant
BXGF02038 Cheilanthes tenuifolia Cheilanthes tenuifolia Medicinal Plant
BXGF02092 Acanthosyris spinescens Acanthosyris spinescens Human Edible Plant
BXGF02140 Euphorbia nivulia Euphorbia nivulia Medicinal Plant
BXGF02159 Udotea cyathiformis Udotea cyathiformis Others
BXGF02190 Gleditsia triacanthos Gleditsia triacanthos Medicinal Plant
BXGF02234 Ilex macropoda Ilex macropoda Medicinal Plant
BXGF02263 Lycium cestroides Lycium cestroides Others
BXGF02280 Pterocaulon alopecuroides Pterocaulon alopecuroides Medicinal Plant
BXGF02284 Palhinhaea cernua Palhinhaea cernua Medicinal Plant
BXGF02297 Paepalanthus hilairei Paepalanthus hilairei Others
BXGF02329 Helipterum venustum Helipterum venustum Others
BXGF03073 Eruca vesicaria subsp. sativa Eruca vesicaria subsp. sativa 0
BXGF03199 Combretum indicum Combretum indicum Medicinal Plant
BXGF04079 Senna siamea Senna siamea Medicinal Plant
BXGF04113 Monostroma fuscum Monostroma fuscum Others
BXGF04251 Uvariopsis tripetala Uvariopsis tripetala Medicinal Plant
BXGF04905 Aloe Aloe Medicinal Plant
BXGF05504 Silybum marianum Silybum marianum Medicinal Plant
BXGF05515 Hedyotis lawsoniae Hedyotis lawsoniae Others
BXGF05768 Tetracera rosiflora Tetracera rosiflora Others
BXGF05853 Cannabis sativa Cannabis sativa Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease