Showing entry for Mangiferin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0006367
Compound NameMangiferin
Structure
FormulaC19H18O11
InchiKeyAEDDIBAIWPIIBD-UHFFFAOYSA-N
SMILESOCC1OC(C(O)C(O)C1O)C1=C(O)C2=C(OC3=C(C=C(O)C(O)=C3)C2=O)C=C1O
InchiInChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2
IUPAC1,3,6,7-tetrahydroxy-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9H-xanthen-9-one
Molecular Weight422.34
Pubchem Id5358385
Chembl IdCHEMBL1329826
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 115144
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT005130 PC4 and SFRS1-interacting protein reviewed Signaling PSIP1 - 92.27 - -
reviewed BXGT005130 PC4 and SFRS1-interacting protein reviewed Signaling PSIP1 - 1742 - -
CHEMBL CHEMBL1329826
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 5011 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 8912 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 3981 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 5623 nM
P09923 BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI IC50 '=' 262 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 19011 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 31622 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 7519 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 2818 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 3548 nM
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Potency '=' 25118 nM
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL EC50 '>' 100000 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 3981 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 3981 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 5011 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency '=' 7079 nM
P09923 BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI IC50 '=' 1190 nM
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 25118 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 25118 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 39810 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 39810 nM
P62826 BXGT011463 GTP-binding nuclear protein Ran reviewed Enzyme modulator RAN Potency - 39810 nM
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 28183 nM
P03070 BXGT006016 Large T antigen reviewed - IC50 - 8630 nM
P10696 BXGT007603 Alkaline phosphatase, germ cell type reviewed Enzyme ALPG IC50 '=' 2710 nM
Q9Y618 BXGT022315 Nuclear receptor corepressor 2 reviewed Transcription factor NCOR2 IC50 '>' 39841 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG IC50 '>' 39841 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 30131 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 11220 nM
P24822 BXGT008996 Intestinal-type alkaline phosphatase reviewed - Iap IC50 '=' 14000 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 35481 nM
Q9Y468 BXGT022270 Lethal(3)malignant brain tumor-like protein 1 reviewed Epigenetic regulator L3MBTL1 Potency '=' 3162 nM
Q9Y5X4 BXGT022306 Photoreceptor-specific nuclear receptor reviewed Nuclear receptor NR2E3 IC50 '>' 39841 nM
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 10000 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 22387 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 7943 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 2377 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 6513 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 7943 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 15003 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 84921 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 35481 nM
P55210 BXGT011110 Caspase-7 reviewed Enzyme CASP7 Potency '=' 19952 nM
Q77YF9 BXGT016886 Protein Vpr unreviewed - vpr Potency - 63095 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 281 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 17740 nM
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 12589 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00106 Mango Mangifera indica Fruits
BXGF00823 Fruits Fruits
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease