Showing entry for Voltage-dependent L-type calcium channel subunit alpha-1F


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004901
Protein NameVoltage-dependent L-type calcium channel subunit alpha-1F
Uniport IdO60840
GeneCACNA1F
Gene Id778
DomainCAC1F_C; Ca_chan_IQ; GPHH; Ion_trans
Pfam PF08763   PF16885   PF16905   PF00520  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04725 Cholinergic synapse
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.2 Endocrine system hsa04912 GnRH signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.2 Endocrine system hsa04927 Cortisol synthesis and secretion
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
6. Human Diseases 6.4 Neurodegenerative diseases hsa05010 Alzheimer disease
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0070509 calcium ion import
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0061337 cardiac conduction
Biological Process GO:0050908 detection of light stimulus involved in visual perception
Biological Process GO:1901386 negative regulation of voltage-gated calcium channel activity
Biological Process GO:0034765 regulation of ion transmembrane transport
Biological Process GO:0050856 regulation of T cell receptor signaling pathway
Biological Process GO:0043029 T cell homeostasis
Biological Process GO:0007601 visual perception
molecular function GO:0008331 high voltage-gated calcium channel activity
molecular function GO:0046872 metal ion binding
molecular function GO:0005245 voltage-gated calcium channel activity
cellular component GO:0016021 integral component of membrane
cellular component GO:0043204 perikaryon
cellular component GO:0001750 photoreceptor outer segment
cellular component GO:0005886 plasma membrane
cellular component GO:0005891 voltage-gated calcium channel complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001916 BXGD000089 Albinism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases
C0002418 BXGD000112 Amblyopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0004106 BXGD000254 Astigmatism Eye Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009398 BXGD000604 Color vision defect Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0020490 BXGD001403 Hyperopia Eye Diseases
C0020630 BXGD001454 Hypophosphatasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0085635 BXGD003217 Photopsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0151891 BXGD003499 Retinal depigmentation Pathological Conditions, Signs and Symptoms; Eye Diseases; Skin and Connective Tissue Diseases
C0152191 BXGD003556 Scotoma, Central Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0152200 BXGD003557 Achromatopsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0153594 BXGD003669 Malignant neoplasm of testis Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0268412 BXGD005937 Infantile hypophosphatasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0268505 BXGD005968 Ocular albinism, type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases
C0271092 BXGD006161 Progressive cone dystrophy (without rod involvement) Eye Diseases
C0271183 BXGD006169 Severe myopia Eye Diseases
C0280793 BXGD006764 Mixed Oligodendroglioma-Astrocytoma Neoplasms
C0302129 BXGD006830 Achromatopsia 1 Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0339535 BXGD007263 Night blindness, congenital stationary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0394006 BXGD008166 Dysequilibrium syndrome Nervous System Diseases
C0476397 BXGD008991 Electroretinogram abnormal
C0751396 BXGD010425 Well Differentiated Oligodendroglioma Neoplasms
C0752124 BXGD010672 Spinocerebellar Ataxia Type 6 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C1298695 BXGD012251 Hypoplasia of optic disc Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1306122 BXGD012355 Oguchi disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1744705 BXGD013750 Atrophy of optic disc Eye Diseases; Nervous System Diseases
C1832916 BXGD013883 Timothy syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Mental Disorders; Cardiovascular Diseases
C1845407 BXGD014745 CONE-ROD DYSTROPHY, X-LINKED, 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1845977 BXGD014769 X- linked recessive
C1848172 BXGD014908 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1849394 BXGD015048 Enhanced S-Cone Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1849792 BXGD015085 Achromatopsia 3 Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C1850362 BXGD015134 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1857618 BXGD015721 Achromatopsia 2 Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C1858806 BXGD015830 CONE-ROD DYSTROPHY 3 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1864877 BXGD016267 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1998028 BXGD016865 Photoreceptor degeneration Eye Diseases
C2673946 BXGD017234 Foveal hypoplasia (finding)
C2931258 BXGD017991 Amaurosis congenita of Leber, type 1 Eye Diseases
C3151111 BXGD018397 Abnormal light- and dark-adapted electroretinogram
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3495587 BXGD018996 Night Blindness, Congenital Stationary, Type 1A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3501847 BXGD019030 Night blindness, congenital stationary, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3711543 BXGD019396 X-Linked Csnb Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3899649 BXGD020089 Childhood Oligoastrocytoma Neoplasms
C4016457 BXGD020339 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A, SEVERE
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4024756 BXGD021405 Abnormality of macular pigmentation
C4041558 BXGD021877 Cone-rod synaptic disorder, congenital nonprogressive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4048798 BXGD021909 Complete congenital stationary night blindness
C4072995 BXGD022031 Difficulty adjusting from light to dark
C4073107 BXGD022039 Incomplete congenital stationary night blindness
C4085590 BXGD022119 Cone-Rod Dystrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4316870 BXGD022707 Abnormality of the eye
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002867 Lappaurin 284.74
BXGC0003611 Latex 416.57
BXGC0006372 Ergocalciferol 396.65
BXGC0007525 (-)-Menthol 156.27
BXGC0014695 Loratadine 382.14
BXGC0024988 Nifedipine 346.12
BXGC0035201 Quinidine 324.18
BXGC0042114 Solifenacin 362.2
BXGC0044017 Verapamil 454.28
BXGC0044810 Lamivudine 229.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein