Showing entry for Voltage-dependent L-type calcium channel subunit alpha-1S


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013392
Protein NameVoltage-dependent L-type calcium channel subunit alpha-1S
Uniport IdQ13698
GeneCACNA1S
Gene Id779
DomainCa_chan_IQ; GPHH; Ion_trans
Pfam PF08763   PF16905   PF00520  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04725 Cholinergic synapse
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.2 Endocrine system hsa04912 GnRH signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.2 Endocrine system hsa04927 Cortisol synthesis and secretion
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
6. Human Diseases 6.4 Neurodegenerative diseases hsa05010 Alzheimer disease
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0070509 calcium ion import
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0061337 cardiac conduction
Biological Process GO:0071313 cellular response to caffeine
Biological Process GO:0006936 muscle contraction
Biological Process GO:0034765 regulation of ion transmembrane transport
molecular function GO:0005516 calmodulin binding
molecular function GO:0008331 high voltage-gated calcium channel activity
molecular function GO:0046872 metal ion binding
molecular function GO:0005245 voltage-gated calcium channel activity
cellular component GO:0005737 cytoplasm
cellular component GO:0031674 I band
cellular component GO:1990454 L-type voltage-gated calcium channel complex
cellular component GO:0005886 plasma membrane
cellular component GO:0030315 T-tubule
cellular component GO:0005891 voltage-gated calcium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-419037 NCAM1 interactions
R-HSA-422475 Axon guidance
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0009917 BXGD000635 Contracture Musculoskeletal Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017654 BXGD001136 Glomerular Filtration Rate
C0018021 BXGD001162 Goiter Endocrine System Diseases
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0020440 BXGD001383 Hypercapnia Pathological Conditions, Signs and Symptoms
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0020461 BXGD001395 Hyperkalemia Nutritional and Metabolic Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0020608 BXGD001443 Hypodontia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0020621 BXGD001449 Hypokalemia Nutritional and Metabolic Diseases
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024591 BXGD001789 Malignant hyperpyrexia due to anesthesia Pathological Conditions, Signs and Symptoms
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0026896 BXGD001946 Myasthenia Gravis Neoplasms; Immune System Diseases; Nervous System Diseases
C0027080 BXGD001969 Myoglobinuria Musculoskeletal Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030252 BXGD002199 Palpitations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0030443 BXGD002224 Familial Periodic Paralysis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0034155 BXGD002468 Purpura, Thrombotic Thrombocytopenic Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0034372 BXGD002480 Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0035232 BXGD002517 Respiratory Paralysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0035410 BXGD002546 Rhabdomyolysis Musculoskeletal Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039231 BXGD002799 Tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0039240 BXGD002804 Supraventricular tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042834 BXGD003004 Vital capacity
C0080274 BXGD003111 Urinary Retention Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085681 BXGD003237 Hyperphosphatemia (disorder) Nutritional and Metabolic Diseases
C0151636 BXGD003451 Premature ventricular contractions Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151723 BXGD003466 Hypomagnesemia Nutritional and Metabolic Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151878 BXGD003495 Prolonged QT interval Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0154141 BXGD003703 Thyrotoxicosis with toxic single thyroid nodule Endocrine System Diseases
C0154143 BXGD003704 Toxic multinodular goiter Endocrine System Diseases
C0155922 BXGD003833 Tooth development and eruption disorder Mental Disorders; Stomatognathic Diseases
C0162557 BXGD003956 Liver Failure, Acute Digestive System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0201976 BXGD004063 Creatinine measurement, serum (procedure)
C0206667 BXGD004228 Adrenal Cortical Adenoma Neoplasms; Endocrine System Diseases
C0220981 BXGD004348 Metabolic acidosis Nutritional and Metabolic Diseases
C0221170 BXGD004400 Muscular stiffness Nervous System Diseases
C0231835 BXGD004527 Tachypnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0234119 BXGD004622 Neuromuscular inhibition
C0235063 BXGD004718 Respiratory Depression Respiratory Tract Diseases
C0238358 BXGD004917 Hypokalemic periodic paralysis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0264906 BXGD005434 Second degree atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0268024 BXGD005803 Hyperkalemia, diminished renal excretion Digestive System Diseases; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0268445 BXGD005948 Normokalemic Periodic Paralysis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0268446 BXGD005949 Thyrotoxic periodic paralysis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0270960 BXGD006141 Congenital myopathy (disorder) Musculoskeletal Diseases; Nervous System Diseases
C0270984 BXGD006149 Metabolic myopathy Musculoskeletal Diseases; Nervous System Diseases
C0399352 BXGD008236 Developmental absence of tooth Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0476403 BXGD008992 Electromyogram abnormal
C0520739 BXGD009106 Hereditary pyropoikilocytosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0520878 BXGD009117 Shortened PR interval Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0523953 BXGD009226 Cardiac troponin T measurement
C0595921 BXGD009626 Intraocular pressure disorder Eye Diseases
C0742747 BXGD010067 High-output congestive heart failure Cardiovascular Diseases
C0751401 BXGD010427 Ophthalmoparesis Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0751951 BXGD010648 Central Core Myopathy (disorder) Musculoskeletal Diseases; Nervous System Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1268935 BXGD011997 Congenital Thrombotic Thrombocytopenic Purpura Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C1279412 BXGD012121 periodic paralysis (finding) Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1333762 BXGD012639 Gastric Cardia Adenocarcinoma
C1563715 BXGD013389 Andersen Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1631597 BXGD013480 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1836296 BXGD014105 Muscle Weakness Lower Limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1838647 BXGD014329 RETINITIS PIGMENTOSA 12 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1853237 BXGD015319 Isolated cases
C1855520 BXGD015506 Hyperglycemia, Postprandial Nutritional and Metabolic Diseases
C1855580 BXGD015515 Exercise-induced muscle fatigue
C1866077 BXGD016370 MALIGNANT HYPERTHERMIA, SUSCEPTIBILITY TO, 5
C1868598 BXGD016514 PARIETAL FORAMINA Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1970117 BXGD016807 Tooth Agenesis, Selective, With Orofacial Cleft Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C1970118 BXGD016808 Hypodontia Oligodontia with Orofacial Cleft Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2749982 BXGD017639 THYROTOXIC PERIODIC PARALYSIS, SUSCEPTIBILITY TO, 1
C2930984 BXGD017928 Malignant hyperthermia susceptibility type 5 Pathological Conditions, Signs and Symptoms
C3160712 BXGD018467 Palpitations, CTCAE
C3489529 BXGD018933 Tooth Agenesis, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C3714580 BXGD019414 Hypokalemic periodic paralysis type 1
C3714697 BXGD019424 AV Block Second Degree by ECG Finding Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C3807306 BXGD019531 Acute rhabdomyolysis Musculoskeletal Diseases
C4020730 BXGD020473 Increased intramyocellular lipid droplets
C4021526 BXGD020653 Exercise-induced rhabdomyolysis Musculoskeletal Diseases
C4021553 BXGD020669 Periodic hypokalemic paresis
C4022587 BXGD020928 Fatigable weakness of respiratory muscles
C4022754 BXGD020983 Episodic hypokalemia Nutritional and Metabolic Diseases
C4023104 BXGD021108 Intermittent painful muscle spasms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4024608 BXGD021339 Necrotizing myopathy Musculoskeletal Diseases; Nervous System Diseases
C4024700 BXGD021375 Elevated creatine kinase after exercise
C4024709 BXGD021380 Transient hypophosphatemia Nutritional and Metabolic Diseases
C4025238 BXGD021601 Generalized morning stiffness
C4025572 BXGD021671 Episodic flaccid weakness Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4025578 BXGD021675 Late-onset proximal muscle weakness
C4073214 BXGD022066 Abnormality of masseter muscle
C4082304 BXGD022090 Oligodontia
C4310638 BXGD022609 TOOTH AGENESIS, SELECTIVE, 9
C4531203 BXGD023204 Cardiomyocyte mitochondrial proliferation
C4552839 BXGD023527 Hypomagnesemia, CTCAE
C4751572 BXGD024084 Periodic paralysis with transient compartment-like syndrome Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0002867 Lappaurin 284.74
BXGC0003611 Latex 416.57
BXGC0003705 Chloride 35.45
BXGC0006372 Ergocalciferol 396.65
BXGC0007525 (-)-Menthol 156.27
BXGC0014695 Loratadine 382.14
BXGC0024988 Nifedipine 346.12
BXGC0035201 Quinidine 324.18
BXGC0042114 Solifenacin 362.2
BXGC0044017 Verapamil 454.28
BXGC0044810 Lamivudine 229.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein