Showing entry for Transient receptor potential cation channel subfamily A member 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005151
Protein NameTransient receptor potential cation channel subfamily A member 1
Uniport IdO75762
GeneTRPA1
Gene Id8989
DomainAnk; Ion_trans
Pfam PF12796   PF00520  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.7 Sensory system hsa04750 Inflammatory mediator regulation of TRP channels
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0050968 detection of chemical stimulus involved in sensory perception of pain
Biological Process GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
Biological Process GO:0006811 ion transport
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0009409 response to cold
Biological Process GO:0042493 response to drug
Biological Process GO:0042542 response to hydrogen peroxide
Biological Process GO:0014070 response to organic cyclic compound
Biological Process GO:0010033 response to organic substance
Biological Process GO:0048265 response to pain
Biological Process GO:0019233 sensory perception of pain
Biological Process GO:0050955 thermoception
molecular function GO:0015278 calcium-release channel activity
molecular function GO:0015267 channel activity
molecular function GO:0042802 identical protein binding
molecular function GO:0097604 temperature-gated cation channel activity
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0032421 stereocilium bundle
Reactome
Pathway Id Pathway Name
R-HSA-2672351 Stimuli-sensing channels
R-HSA-3295583 TRP channels
R-HSA-382551 Transport of small molecules
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0001883 BXGD000086 Airway Obstruction Respiratory Tract Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002768 BXGD000128 Congenital Pain Insensitivity Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0002873 BXGD000133 Anemia of chronic disease Hemic and Lymphatic Diseases
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004610 BXGD000281 Bacteremia Pathological Conditions, Signs and Symptoms; Infections
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009766 BXGD000629 Allergic Conjunctivitis Eye Diseases; Immune System Diseases
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0010201 BXGD000654 Chronic cough Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0010692 BXGD000686 Cystitis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0011303 BXGD000712 Demyelinating Diseases Nervous System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011616 BXGD000739 Contact Dermatitis Skin and Connective Tissue Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011882 BXGD000761 Diabetic Neuropathies Nervous System Diseases; Endocrine System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014599 BXGD000939 Epithelial hyperplasia Pathological Conditions, Signs and Symptoms
C0015674 BXGD001012 Chronic Fatigue Syndrome Infections; Musculoskeletal Diseases; Nervous System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017567 BXGD001119 Gingival Hypertrophy Stomatognathic Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020517 BXGD001415 Hypersensitivity Immune System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0023051 BXGD001602 Laryngeal Diseases Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0034735 BXGD002487 Raynaud Phenomenon Cardiovascular Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0036280 BXGD002591 Burn scar Pathological Conditions, Signs and Symptoms; Wounds and Injuries
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0037383 BXGD002692 Sneezing Pathological Conditions, Signs and Symptoms
C0040580 BXGD002877 Tracheal Diseases Respiratory Tract Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0043395 BXGD003046 Yellow Fever Infections
C0085096 BXGD003123 Peripheral Vascular Diseases Cardiovascular Diseases
C0085129 BXGD003128 Bronchial Hyperreactivity Respiratory Tract Diseases
C0085423 BXGD003173 Gram-Negative Bacterial Infections Infections
C0085624 BXGD003211 Burning sensation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085625 BXGD003212 Hypoalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0151718 BXGD003464 Hypocholesterolemia Nutritional and Metabolic Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152027 BXGD003523 Sensory Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0154723 BXGD003737 Migraine with Aura Nervous System Diseases
C0162820 BXGD003985 Dermatitis, Allergic Contact Skin and Connective Tissue Diseases; Immune System Diseases
C0162830 BXGD003987 Dermatitis, Phototoxic Skin and Connective Tissue Diseases
C0175694 BXGD004002 Smith-Lemli-Opitz Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0178422 BXGD004027 Cramp in foot
C0178782 BXGD004034 Orofacial Pain Pathological Conditions, Signs and Symptoms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0184567 BXGD004039 Acute onset pain Pathological Conditions, Signs and Symptoms
C0206139 BXGD004159 Lichen Planus, Oral Skin and Connective Tissue Diseases; Stomatognathic Diseases
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0234230 BXGD004635 Pain, Burning Pathological Conditions, Signs and Symptoms
C0234238 BXGD004637 Ache Pathological Conditions, Signs and Symptoms
C0234245 BXGD004641 Visceral Pain Pathological Conditions, Signs and Symptoms
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0234254 BXGD004648 Radiating pain Pathological Conditions, Signs and Symptoms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0262385 BXGD005233 Autonomic nervous system imbalance Nervous System Diseases
C0262985 BXGD005277 Psoriasiform eczema Skin and Connective Tissue Diseases
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0267071 BXGD005730 Oropharyngeal Dysphagia Digestive System Diseases; Otorhinolaryngologic Diseases
C0268849 BXGD006045 Overactive Detrusor Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0272138 BXGD006308 Erythroblastosis
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0391976 BXGD008022 Pain Disorder Mental Disorders
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0432306 BXGD008770 Ichthyosis Bullosa of Siemens Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0458247 BXGD008904 Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0458257 BXGD008905 Pain, Splitting Pathological Conditions, Signs and Symptoms
C0458259 BXGD008906 Pain, Crushing Pathological Conditions, Signs and Symptoms
C0521585 BXGD009145 Gastrointestinal mucositis Digestive System Diseases; Stomatognathic Diseases
C0549386 BXGD009373 Sensation of warmth
C0549523 BXGD009386 Oropharynx (excludes nasopharynx)
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600041 BXGD009685 Infective cystitis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0730321 BXGD009957 Punctate inner choroidopathy Eye Diseases
C0748035 BXGD010187 pruritus chronic
C0751074 BXGD010313 Diabetic Neuralgia Nervous System Diseases; Endocrine System Diseases
C0751211 BXGD010350 Hyperalgesia, Primary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751212 BXGD010351 Hyperalgesia, Secondary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751213 BXGD010352 Tactile Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751381 BXGD010421 Foley-Denny-Brown Syndrome Nervous System Diseases
C0751407 BXGD010429 Pain, Migratory Pathological Conditions, Signs and Symptoms
C0751408 BXGD010430 Suffering, Physical Pathological Conditions, Signs and Symptoms
C0878773 BXGD011391 Overactive Bladder Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0948249 BXGD011521 Femoral artery occlusion Cardiovascular Diseases
C1096717 BXGD011641 Pain during injection
C1275685 BXGD012092 Avellino corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1397307 BXGD012996 Cardiac fibrosis
C1527358 BXGD013279 Phototoxicity Skin and Connective Tissue Diseases
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1855739 BXGD015538 Indifference to Pain, Congenital, Autosomal Recessive Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2347748 BXGD017041 Adult Erythroleukemia
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3178766 BXGD018535 Nociceptive Pain Pathological Conditions, Signs and Symptoms
C3276706 BXGD018694 Small Fiber Neuropathy Nervous System Diseases
C3489856 BXGD018953 Cold Hypersensitivity Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3808667 BXGD019552 EPISODIC PAIN SYNDROME, FAMILIAL, 1
C3873567 BXGD019863 Peripheral neuropathy due to and following chemotherapy Nervous System Diseases
C3875321 BXGD019874 Inflammatory dermatosis Skin and Connective Tissue Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4520840 BXGD023041 Erythroleukemia (Erythroid/Myeloid) Neoplasms; Hemic and Lymphatic Diseases
C4554601 BXGD023566 Amyloidosis cutis dyschromia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000533 trans-Cinnamyl alcohol 134.18
BXGC0000664 Maxepa 314.46
BXGC0000929 4-Hydroxy-2E-nonenal 156.22
BXGC0001767 (E)-Resveratrol 228.25
BXGC0002358 Allitridin 178.34
BXGC0002586 Calcium 40.08
BXGC0002594 1,2-(2-Propenyl)-disulfane 146.27
BXGC0002599 2-Propene-1-sulfinothiocic-acids 2-propenyl ester 162.27
BXGC0002619 Di-2-propenyl-sulfane 114.21
BXGC0002780 (E)-Butylidene phthalide 188.23
BXGC0002796 Nicotine 162.23
BXGC0002873 3-Benzylisothiocyanate 149.21
BXGC0002953 2-Phenethyl isothiocyanate 163.24
BXGC0003519 Ligusticide 190.24
BXGC0003949 Thymunic acid 150.22
BXGC0004227 1-Isothiocyanato-6-(methylthio)hexane 189.34
BXGC0004230 Berteroin 175.32
BXGC0004283 2-Propenal 56.06
BXGC0004587 (E)-3-Phenyl-2-propenal 132.16
BXGC0004669 2-Butylisothiocyanate 115.2
BXGC0004687 Isobutyl isothiocyanate 115.2
BXGC0004689 Isopropyl isothiocyanate 101.17
BXGC0004717 4-Hydroxybenzyl isothiocyanate 165.21
BXGC0004831 3,4',5-Biphenyltriol 202.21
BXGC0005684 Erucin 161.29
BXGC0005787 4-Isothiocyanato-1-butene 113.18
BXGC0005814 Propanal 58.08
BXGC0006092 3-Isothiocyanato-1-propene 99.15
BXGC0006095 (??)-Citronellyl acetate 198.31
BXGC0006242 5-Isothiocyanato-1-pentene 127.21
BXGC0006318 Ibervirin 147.26
BXGC0007011 (R)-Perillaldehyde 150.22
BXGC0007134 Perilla ketone 166.22
BXGC0007525 (-)-Menthol 156.27
BXGC0007528 p-Menthan-3-ol 156.27
BXGC0007535 5-Isopropyl-2-methylphenol 150.22
BXGC0009626 7-Isothiocyanato-1-heptene 155.26
BXGC0009628 6-Isothiocyanato-1-hexene 141.23
BXGC0009632 1-Isothiocyanato-7-(methylthio)heptane 203.37
BXGC0010636 Phosphatidylcholine 760.08
BXGC0014324 3,5,3',4',5'-pentahydroxy-stilbene 260.07
BXGC0016747 Camphor 152.12
BXGC0022418 evodiamine 303.14
BXGC0023976 Hydroxy-Alpha-Sanshool 263.19
BXGC0025144 Prostaglandin A1 336.23
BXGC0028278 Rutaecarpine 287.11
BXGC0039083 Pinosylvin 212.08
BXGC0039750 Resveratrol 4'-Methyl Ether 242.09
BXGC0040150 Cannabidiol 314.22
BXGC0040952 Dihydroresveratrol 230.09
BXGC0042580 Coronaridine 338.2
BXGC0042870 Piceatannol 244.07
BXGC0042963 3,5-O-Dimethylpinosylvin 240.12
BXGC0043648 (-)-Camphor 152.12
BXGC0044162 Polygodial 234.16
BXGC0045996 Voacristine 384.2
BXGC0046067 Rhapontigenin 272.1
BXGC0047396 bromoacetone 135.95
BXGC0049939 Pentenal 84.06
BXGC0051357 Trismethoxyresveratrol 270.13
BXGC0051716 2-butenal 70.04
BXGC0053078 Pinosylvin Methyl Ether 226.1
BXGC0053405 Voacangine 368.21
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein