acompound

Showing entry for 5-Hydroxyflavone

General Compound Information
BXGC Id	BXGC0025887
Compound Name	5-Hydroxyflavone
Structure
Formula	C15H10O3
InchiKey	IYBLVRRCNVHZQJ-UHFFFAOYSA-N
SMILES	Oc1cccc2c1c(=O)cc(o2)c1ccccc1
Inchi	InChI=1S/C15H10O3/c16-11-7-4-8-13-15(11)12(17)9-14(18-13)10-5-2-1-3-6-10/h1-9,16H
IUPAC	5-hydroxy-2-phenylchromen-4-one
Molecular Weight	238.06
Pubchem Id	68112
Chembl Id	CHEMBL16807

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1

Binding DB

50049385

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT009437	Adenosine receptor A2a	reviewed		Adora2a	6166	-	-	-
reviewed	BXGT009016	Adenosine receptor A1	reviewed		Adora1	2188	-	-	-
reviewed	BXGT009437	Adenosine receptor A2a	reviewed		Adora2a	6200	-	-	-
reviewed	BXGT009016	Adenosine receptor A1	reviewed		Adora1	2170	-	-	-
reviewed	BXGT007552	Androgen receptor	reviewed	Nuclear receptor	AR	-	300	-	-
reviewed	BXGT022265	Sialidase-2	reviewed	Enzyme	NEU2	-	>1000000	-	-
reviewed	BXGT006265	Cytochrome P450 1A1	reviewed	Enzyme	CYP1A1	-	4030	-	-
reviewed	BXGT007552	Androgen receptor	reviewed	Nuclear receptor	AR	-	832	-	-
reviewed	BXGT007552	Androgen receptor	reviewed	Nuclear receptor	AR	-	840	-	-

CHEMBL

CHEMBL16807

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P04150	BXGT006154	Glucocorticoid receptor	reviewed	Nuclear receptor	NR3C1	Activity	-	-	-
P11388	BXGT007697	DNA topoisomerase 2-alpha	reviewed	-	TOP2A	Activity	-	-	-
Q965D5	BXGT019600	Enoyl-acyl-carrier protein reductase	unreviewed	-	fabI	Activity	-	-	-
Q9ES14	BXGT020314	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	-	Gabre	Ki	'='	1900	nM
Q91ZM7	BXGT019327	GABA theta subunit	unreviewed	-	Gabrq	Ki	'='	1900	nM
P63138	BXGT011502	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	-	Gabrb2	Ki	'='	1900	nM
P63079	BXGT011491	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	-	Gabrb3	Ki	'='	1900	nM
P62813	BXGT011460	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	-	Gabra1	Ki	'='	1900	nM
P30191	BXGT009410	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	-	Gabra6	Ki	'='	1900	nM
P28473	BXGT009261	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	-	Gabrg3	Ki	'='	1900	nM
P28471	BXGT009259	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	-	Gabra4	Ki	'='	1900	nM
P23576	BXGT008885	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	-	Gabra2	Ki	'='	1900	nM
P23574	BXGT008884	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	-	Gabrg1	Ki	'='	1900	nM
P20236	BXGT008551	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	-	Gabra3	Ki	'='	1900	nM
P19969	BXGT008536	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	-	Gabra5	Ki	'='	1900	nM
P18508	BXGT008412	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	-	Gabrg2	Ki	'='	1900	nM
P18506	BXGT008410	Gamma-aminobutyric acid receptor subunit delta	reviewed	-	Gabrd	Ki	'='	1900	nM
P15431	BXGT008122	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	-	Gabrb1	Ki	'='	1900	nM
O09028	BXGT004049	Gamma-aminobutyric acid receptor subunit pi	reviewed	-	Gabrp	Ki	'='	1900	nM
Q9ES14	BXGT020314	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	-	Gabre	GABA ratio	'='	1	-
Q91ZM7	BXGT019327	GABA theta subunit	unreviewed	-	Gabrq	GABA ratio	'='	1	-
P63138	BXGT011502	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	-	Gabrb2	GABA ratio	'='	1	-
P63079	BXGT011491	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	-	Gabrb3	GABA ratio	'='	1	-
P62813	BXGT011460	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	-	Gabra1	GABA ratio	'='	1	-
P30191	BXGT009410	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	-	Gabra6	GABA ratio	'='	1	-
P28473	BXGT009261	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	-	Gabrg3	GABA ratio	'='	1	-
P28471	BXGT009259	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	-	Gabra4	GABA ratio	'='	1	-
P23576	BXGT008885	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	-	Gabra2	GABA ratio	'='	1	-
P23574	BXGT008884	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	-	Gabrg1	GABA ratio	'='	1	-
P20236	BXGT008551	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	-	Gabra3	GABA ratio	'='	1	-
P19969	BXGT008536	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	-	Gabra5	GABA ratio	'='	1	-
P18508	BXGT008412	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	-	Gabrg2	GABA ratio	'='	1	-
P18506	BXGT008410	Gamma-aminobutyric acid receptor subunit delta	reviewed	-	Gabrd	GABA ratio	'='	1	-
P15431	BXGT008122	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	-	Gabrb1	GABA ratio	'='	1	-
O09028	BXGT004049	Gamma-aminobutyric acid receptor subunit pi	reviewed	-	Gabrp	GABA ratio	'='	1	-
P0DMS8	BXGT007506	Adenosine receptor A3	reviewed	G-protein coupled receptor	ADORA3	Displacement	'='	47	%
P10636	BXGT007596	Microtubule-associated protein tau	reviewed	-	MAPT	Potency	'='	15848	nM
Q05769	BXGT012834	Prostaglandin G/H synthase 2	reviewed	-	Ptgs2	Inhibition	'='	45	%
O75496	BXGT005132	Geminin	reviewed	-	GMNN	Potency	-	2310	nM
Q9Y3R4	BXGT022265	Sialidase-2	reviewed	Enzyme	NEU2	IC50	'>'	1000000	nM
Q9UNA4	BXGT021785	DNA polymerase iota	reviewed	-	POLI	Potency	-	89125	nM
P10275	BXGT007552	Androgen receptor	reviewed	Nuclear receptor	AR	IC50	'='	300	nM
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	Potency	'='	19952	nM
P00352	BXGT005510	Retinal dehydrogenase 1	reviewed	Enzyme	ALDH1A1	Potency	'='	39810	nM
P10275	BXGT007552	Androgen receptor	reviewed	Nuclear receptor	AR	IC50	'='	831	nM
P16116	BXGT008197	Aldo-keto reductase family 1 member B1	reviewed	-	AKR1B1	Inhibition	'='	0	%
P0DMS8	BXGT007506	Adenosine receptor A3	reviewed	G-protein coupled receptor	ADORA3	pKi(uM)	-	-	-
P11388	BXGT007697	DNA topoisomerase 2-alpha	reviewed	-	TOP2A	Activity	'<'	50	%
P25099	BXGT009016	Adenosine receptor A1	reviewed	-	Adora1	Ki	'='	2170	nM
P04062	BXGT006140	Lysosomal acid glucosylceramidase	reviewed	-	GBA	Potency	-	11220	nM
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	Potency	'='	6309	nM
Q965D7	BXGT019602	Beta-hydroxyacyl-ACP dehydratase	unreviewed	-	fabZ	Activity	-	-	-
P49798	BXGT010745	Regulator of G-protein signaling 4	reviewed	Enzyme modulator	RGS4	Potency	-	8436	nM
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	reviewed	-	KMT2A	Potency	'='	39810	nM
O00255	BXGT003903	Menin	reviewed	-	MEN1	Potency	'='	39810	nM
P16050	BXGT008184	Arachidonate 15-lipoxygenase	reviewed	Enzyme	ALOX15	Potency	'='	19952	nM
P30543	BXGT009437	Adenosine receptor A2a	reviewed	-	Adora2a	pKi(uM)	'='	0	-
P25099	BXGT009016	Adenosine receptor A1	reviewed	-	Adora1	pKi(uM)	'='	0	-
P30543	BXGT009437	Adenosine receptor A2a	reviewed	-	Adora2a	Ki	'='	6200	nM
P10275	BXGT007552	Androgen receptor	reviewed	Nuclear receptor	AR	IC50	'='	840	nM
Q965D6	BXGT019601	3-oxoacyl-acyl-carrier protein reductase	unreviewed	-	fabG	Activity	-	-	-
P04150	BXGT006154	Glucocorticoid receptor	reviewed	Nuclear receptor	NR3C1	EC150	'='	6	uM
O60218	BXGT004858	Aldo-keto reductase family 1 member B10	reviewed	Enzyme	AKR1B10	Inhibition	-	-	-
Q16637	BXGT013646	Survival motor neuron protein	reviewed	Epigenetic regulator	SMN1	Potency	'='	31622	nM
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	IC50	'='	310	nM
P30543	BXGT009437	Adenosine receptor A2a	reviewed	-	Adora2a	pKi(uM)	-	-	-
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	reviewed	-	GNAS	Potency	-	31622	nM
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	reviewed	Enzyme	NFE2L2	Potency	-	35481	nM
P10275	BXGT007552	Androgen receptor	reviewed	Nuclear receptor	AR	EC150	'='	6	uM
Q13148	BXGT013318	TAR DNA-binding protein 43	reviewed	-	TARDBP	Potency	-	89125	nM
P09917	BXGT006941	Arachidonate 5-lipoxygenase	reviewed	Enzyme	ALOX5	Inhibition	-	-	-
Q16678	BXGT013656	Cytochrome P450 1B1	reviewed	Enzyme	CYP1B1	IC50	'='	210	nM
P04798	BXGT006265	Cytochrome P450 1A1	reviewed	Enzyme	CYP1A1	IC50	'='	4030	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00046	Roman camomile	Chamaemelum nobile	Herbs and Spices
BXGF02518	Schkuhria multiflora	Schkuhria multiflora	Others
BXGF03734	Anthocleista grandiflora	Anthocleista grandiflora	Medicinal Plant
BXGF03743	Helleborus caucasicus	Helleborus caucasicus	Others
BXGF03758	Lespedeza homoloba	Lespedeza homoloba	Medicinal Plant
BXGF03780	Lolium perenne	Lolium perenne	Medicinal Plant
BXGF03793	Hypoestes serpens	Hypoestes serpens	Medicinal Plant
BXGF03806	Primula farinosa	Primula farinosa	Others

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}