Showing entry for Disks large homolog 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011836
Protein NameDisks large homolog 4
Uniport IdP78352
GeneDLG4
Gene Id1742
DomainGuanylate_kin; MAGUK_N_PEST; PDZ; PDZ_assoc; SH3_1
Pfam PF00625   PF10608   PF00595   PF10600   PF00018  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0097113 AMPA glutamate receptor clustering
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0035865 cellular response to potassium ion
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0060997 dendritic spine morphogenesis
Biological Process GO:0045184 establishment of protein localization
Biological Process GO:0007612 learning
Biological Process GO:0035641 locomotory exploration behavior
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0002091 negative regulation of receptor internalization
Biological Process GO:0007399 nervous system development
Biological Process GO:0050885 neuromuscular process controlling balance
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:2000463 positive regulation of excitatory postsynaptic potential
Biological Process GO:0150012 positive regulation of neuron projection arborization
Biological Process GO:0061098 positive regulation of protein tyrosine kinase activity
Biological Process GO:0050806 positive regulation of synaptic transmission
Biological Process GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0035418 protein localization to synapse
Biological Process GO:0043113 receptor clustering
Biological Process GO:0097120 receptor localization to synapse
Biological Process GO:2000821 regulation of grooming behavior
Biological Process GO:0048169 regulation of long-term neuronal synaptic plasticity
Biological Process GO:2000310 regulation of NMDA receptor activity
Biological Process GO:0007165 signal transduction
Biological Process GO:0035176 social behavior
Biological Process GO:0016188 synaptic vesicle maturation
Biological Process GO:0071625 vocalization behavior
molecular function GO:0033130 acetylcholine receptor binding
molecular function GO:0031697 beta-1 adrenergic receptor binding
molecular function GO:0031748 D1 dopamine receptor binding
molecular function GO:0035255 ionotropic glutamate receptor binding
molecular function GO:0019900 kinase binding
molecular function GO:0097109 neuroligin family protein binding
molecular function GO:0031812 P2Y1 nucleotide receptor binding
molecular function GO:0030165 PDZ domain binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0097110 scaffold protein binding
cellular component GO:0032281 AMPA glutamate receptor complex
cellular component GO:0030054 cell junction
cellular component GO:0044300 cerebellar mossy fiber
cellular component GO:0030863 cortical cytoskeleton
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0032839 dendrite cytoplasm
cellular component GO:0043197 dendritic spine
cellular component GO:0030666 endocytic vesicle membrane
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0060076 excitatory synapse
cellular component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0044224 juxtaparanode region of axon
cellular component GO:0031594 neuromuscular junction
cellular component GO:0043005 neuron projection
cellular component GO:0044306 neuron projection terminus
cellular component GO:0044309 neuron spine
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0098839 postsynaptic density membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0045202 synapse
cellular component GO:0097060 synaptic membrane
cellular component GO:0008021 synaptic vesicle
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-1236394 Signaling by ERBB4
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-373760 L1CAM interactions
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
R-HSA-422475 Axon guidance
R-HSA-438064 Post NMDA receptor activation events
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-447038 NrCAM interactions
R-HSA-451306 Ionotropic activity of kainate receptors
R-HSA-451308 Activation of Ca-permeable Kainate Receptor
R-HSA-451326 Activation of kainate receptors upon glutamate binding
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5682910 LGI-ADAM interactions
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6794361 Neurexins and neuroligins
R-HSA-6794361 Neurexins and neuroligins
R-HSA-6794362 Protein-protein interactions at synapses
R-HSA-6794362 Protein-protein interactions at synapses
R-HSA-8849932 Synaptic adhesion-like molecules
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9607240 FLT3 Signaling
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission
R-HSA-9620244 Long-term potentiation
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002622 BXGD000119 Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0008354 BXGD000533 Cholera Infections
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011269 BXGD000710 Dementia, Vascular Nervous System Diseases; Mental Disorders; Cardiovascular Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0019337 BXGD001319 Heroin Dependence Chemically-Induced Disorders; Mental Disorders
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0028768 BXGD002084 Obsessive-Compulsive Disorder Mental Disorders
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030201 BXGD002194 Pain, Postoperative Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0175702 BXGD004008 Williams Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0221163 BXGD004395 Motor Disorders Mental Disorders
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0239849 BXGD005003 Harlequin Fetus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0278061 BXGD006492 Abnormal mental state Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0424166 BXGD008521 Social Anxiety Behavior and Behavior Mechanisms
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0431380 BXGD008680 Cortical Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0523465 BXGD009209 Serum albumin measurement
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0683322 BXGD009782 Mental impairment
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751265 BXGD010370 Learning Disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751956 BXGD010653 Acute Cerebrovascular Accidents Nervous System Diseases; Cardiovascular Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1136382 BXGD011717 Sclerocystic Ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1305855 BXGD012348 Body mass index
C1306341 BXGD012360 Mental handicap
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1836996 BXGD014183 Disproportionate tall stature
C1842937 BXGD014546 AURAL ATRESIA, CONGENITAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1862382 BXGD016125 SVEINSSON CHORIORETINAL ATROPHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1867326 BXGD016447 RETINAL CONE DYSTROPHY 1 Eye Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2938905 BXGD018164 Central Nervous System Sensitization
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3888788 BXGD019984 Minimal hepatic encephalopathy
C4024589 BXGD021330 Aplasia/Hypoplasia of the mandible
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4721773 BXGD023768 Postoperative cognitive dysfunction
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000989 Glutathione 307.32
BXGC0003342 Guanidine 59.07
BXGC0027925 Cpg 363.06
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein