Showing entry for Serine--tRNA ligase, cytoplasmic


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010715
Protein NameSerine--tRNA ligase, cytoplasmic
Uniport IdP49591
GeneSARS1
Gene Id6301
DomainSeryl_tRNA_N; tRNA-synt_2b
Pfam PF02403   PF00587  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa00970 Aminoacyl-tRNA biosynthesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:1904046 negative regulation of vascular endothelial growth factor production
Biological Process GO:0016259 selenocysteine metabolic process
Biological Process GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process
Biological Process GO:0006434 seryl-tRNA aminoacylation
Biological Process GO:0006412 translation
Biological Process GO:0006418 tRNA aminoacylation for protein translation
Biological Process GO:0008033 tRNA processing
molecular function GO:0005524 ATP binding
molecular function GO:0019899 enzyme binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0003723 RNA binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0004828 serine-tRNA ligase activity
molecular function GO:0000049 tRNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-2408522 Selenoamino acid metabolism
R-HSA-2408557 Selenocysteine synthesis
R-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-379724 tRNA Aminoacylation
R-HSA-392499 Metabolism of proteins
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-72766 Translation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006277 BXGD000387 Bronchitis Infections; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008055 BXGD000514 Chikungunya Fever Infections
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009443 BXGD000612 Common Cold Infections; Respiratory Tract Diseases
C0011311 BXGD000714 Dengue Fever Infections
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0014378 BXGD000912 Enterovirus Infections Infections
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017160 BXGD001099 Gastroenteritis Digestive System Diseases
C0018081 BXGD001171 Gonorrhea Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023092 BXGD001609 Lassa Fever Infections
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0025007 BXGD001821 Measles Infections
C0025202 BXGD001832 melanoma Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026936 BXGD001950 Mycoplasma Infections Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0032269 BXGD002342 Pneumococcal Infections Infections
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0034494 BXGD002481 Rabies (disorder) Infections
C0035204 BXGD002511 Respiration Disorders Respiratory Tract Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035242 BXGD002521 Respiratory Tract Diseases Respiratory Tract Diseases
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0036916 BXGD002643 Sexually Transmitted Diseases Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0037090 BXGD002665 Signs and Symptoms, Respiratory Pathological Conditions, Signs and Symptoms
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038271 BXGD002742 Stereotyped Behavior Behavior and Behavior Mechanisms
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039128 BXGD002794 Syphilis Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0040580 BXGD002877 Tracheal Diseases Respiratory Tract Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041912 BXGD002937 Upper Respiratory Infections Infections; Respiratory Tract Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0043046 BXGD003024 Wasting Syndrome Nutritional and Metabolic Diseases
C0043528 BXGD003050 Zoonoses Infections; Animal Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0206061 BXGD004147 Pneumonia, Interstitial Respiratory Tract Diseases
C0206750 BXGD004287 Coronavirus Infections Infections
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0231706 BXGD004518 Circling gait
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0262630 BXGD005262 Reduced concentration span Behavior and Behavior Mechanisms
C0266464 BXGD005676 Polymicrogyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0266999 BXGD005725 Vesicular Stomatitis Infections; Stomatognathic Diseases; Animal Diseases
C0267446 BXGD005749 Acute gastroenteritis Digestive System Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0282687 BXGD006826 Hemorrhagic Fever, Ebola Infections
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346429 BXGD007828 Multiple malignancy Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0431371 BXGD008676 Absence of septum pellucidum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0431380 BXGD008680 Cortical Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0702135 BXGD009908 Primary atypical pneumonia Infections; Respiratory Tract Diseases
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0849640 BXGD010889 skin damage
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C0876973 BXGD011322 Infectious Lung Disorder Infections; Respiratory Tract Diseases
C0919747 BXGD011439 Cytokine storm
C1096184 BXGD011607 West Nile viral infection Infections; Nervous System Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1175175 BXGD011797 Severe Acute Respiratory Syndrome Infections; Respiratory Tract Diseases
C1262020 BXGD011864 Diffuse alveolar damage
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1412002 BXGD013050 Atypical pneumonia Infections; Respiratory Tract Diseases
C1527366 BXGD013280 Salaam Seizures Nervous System Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1848207 BXGD014916 Poor speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1850573 BXGD015154 Slender build Pathological Conditions, Signs and Symptoms
C1854301 BXGD015391 Motor delay Mental Disorders
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859470 BXGD015896 Large basal ganglia
C1868885 BXGD016539 Uncontrolled hypertension
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2062441 BXGD016897 Influenza A
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3665444 BXGD019288 Neutrophilia (disorder) Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C3687801 BXGD019335 Middle Eastern Respiratory Syndrome
C3694279 BXGD019338 Middle East Respiratory Syndrome Infections
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3810365 BXGD019652 Central visual impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4021219 BXGD020582 Multifocal epileptiform discharges
C4048268 BXGD021896 Cortical visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4290046 BXGD022507 trachomatis
C4324356 BXGD022761 End stage lung disease
C4540188 BXGD023243 NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ATAXIA, AND SEIZURES
C4553743 BXGD023548 Spasticity, CTCAE
C4722446 BXGD023803 ENCEPHALITIS/ENCEPHALOPATHY, MILD, WITH REVERSIBLE MYELIN VACUOLIZATION
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0028981 Serine 105.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein