Showing entry for Serine--pyruvate aminotransferase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008661
Protein NameSerine--pyruvate aminotransferase
Uniport IdP21549
GeneAGXT
Gene Id189
DomainAminotran_5
Pfam PF00266  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00260 Glycine, serine and threonine metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00630 Glyoxylate and dicarboxylate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
4. Cellular Processes 4.1 Transport and catabolism hsa04146 Peroxisome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034641 cellular nitrogen compound metabolic process
Biological Process GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
Biological Process GO:0009436 glyoxylate catabolic process
Biological Process GO:0046487 glyoxylate metabolic process
Biological Process GO:0042853 L-alanine catabolic process
Biological Process GO:0019448 L-cysteine catabolic process
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0046724 oxalic acid secretion
Biological Process GO:0006625 protein targeting to peroxisome
Biological Process GO:0042866 pyruvate biosynthetic process
Biological Process GO:0051591 response to cAMP
Biological Process GO:0051384 response to glucocorticoid
molecular function GO:0008453 alanine-glyoxylate transaminase activity
molecular function GO:0016597 amino acid binding
molecular function GO:0042802 identical protein binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0043621 protein self-association
molecular function GO:0030170 pyridoxal phosphate binding
molecular function GO:0004760 serine-pyruvate transaminase activity
molecular function GO:0008483 transaminase activity
cellular component GO:0005829 cytosol
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005782 peroxisomal matrix
cellular component GO:0005777 peroxisome
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-389661 Glyoxylate metabolism and glycine degradation
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-9033241 Peroxisomal protein import
R-HSA-9033241 Peroxisomal protein import
R-HSA-9609507 Protein localization
R-HSA-9609507 Protein localization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002792 BXGD000129 anaphylaxis Immune System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004245 BXGD000264 Atrioventricular Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005890 BXGD000345 Body Height
C0006663 BXGD000403 Calcinosis Nutritional and Metabolic Diseases
C0006664 BXGD000404 Calcinosis cutis Nutritional and Metabolic Diseases
C0007097 BXGD000424 Carcinoma Neoplasms
C0010691 BXGD000685 Cystinuria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0013428 BXGD000840 Dysuria Pathological Conditions, Signs and Symptoms
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014122 BXGD000896 Subacute Bacterial Endocarditis Infections; Cardiovascular Diseases
C0014394 BXGD000914 Enuresis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0016663 BXGD001071 Pathological fracture Wounds and Injuries
C0017086 BXGD001091 Gangrene Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018889 BXGD001243 Helminthiasis Infections
C0018965 BXGD001258 Hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020071 BXGD001356 Hereditary Sensory Autonomic Neuropathy, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0020500 BXGD001408 Hyperoxaluria Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020501 BXGD001409 Primary Hyperoxaluria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021775 BXGD001512 Intermittent Claudication Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0022650 BXGD001568 Kidney Calculi Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0025521 BXGD001876 Inborn Errors of Metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027709 BXGD002026 Nephrocalcinosis Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0029132 BXGD002117 Disorder of the optic nerve Eye Diseases; Nervous System Diseases
C0029464 BXGD002161 Osteosclerosis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0034735 BXGD002487 Raynaud Phenomenon Cardiovascular Diseases
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042109 BXGD002957 Urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0042850 BXGD003007 Vitamin B Deficiency Nutritional and Metabolic Diseases
C0043144 BXGD003032 Wheezing Pathological Conditions, Signs and Symptoms
C0080233 BXGD003110 Tooth Loss Stomatognathic Diseases
C0151825 BXGD003481 Bone pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0162311 BXGD003935 Androgenetic Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220981 BXGD004348 Metabolic acidosis Nutritional and Metabolic Diseases
C0221232 BXGD004413 Welts Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0221347 BXGD004442 Acrocyanosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Respiratory Tract Diseases; Cardiovascular Diseases
C0262444 BXGD005244 Abnormality of the dentition Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0262655 BXGD005264 Recurrent urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0263401 BXGD005298 Cutis marmorata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases; Cardiovascular Diseases; Wounds and Injuries
C0264995 BXGD005444 Occlusion of artery (disorder)
C0268164 BXGD005844 Primary hyperoxaluria, type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0268646 BXGD006023 Isolated cystinuria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279980 BXGD006701 Extra-osseous Ewing's sarcoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0341106 BXGD007389 Eosinophilic esophagitis Digestive System Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0392525 BXGD008052 Nephrolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0451641 BXGD008821 Urolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0476227 BXGD008981 pricking of skin
C0600518 BXGD009711 Choroidal Neovascularization Pathological Conditions, Signs and Symptoms; Eye Diseases
C0687120 BXGD009837 Nephronophthisis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0853068 BXGD010961 Decreased glomerular filtration rate
C0856904 BXGD011125 Allergy to fish
C0948859 BXGD011561 Oxalate crystalluria
C1298681 BXGD012248 Oxalosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1504369 BXGD013138 Allergic disorder of respiratory system Respiratory Tract Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1827849 BXGD013780 IgE-mediated allergic asthma Immune System Diseases
C1833683 BXGD013938 NEPHROLITHIASIS, CALCIUM OXALATE Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1851100 BXGD015194 LAURIN-SANDROW SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1962966 BXGD016678 Retinopathy, CTCAE
C1963077 BXGD016680 Bone Pain, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2939094 BXGD018171 Skin sensitisation
C3662483 BXGD019270 Allergic sensitization
C4021790 BXGD020782 Abnormality of the skeletal system
C4023591 BXGD021224 Abnormality of circulating enzyme level
C4025272 BXGD021615 Peripheral arterial stenosis
C4072992 BXGD022030 Retinal crystals
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4554063 BXGD023559 Bone Pain, CTCAE 5.0
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0000279 L-Alanine 89.09
BXGC0000436 Glycerol 92.09
BXGC0027821 4-deoxypyridoxine 5'-phosphate 233.05
BXGC0028981 Serine 105.04
BXGC0034206 pyridoxamine phosphate 248.06
BXGC0042315 1,4-dioxane 88.05
BXGC0043088 Pyridoxal Phosphate 247.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein