acompound

Showing entry for Bicuculline

General Compound Information
BXGC Id	BXGC0030085
Compound Name	Bicuculline
Structure
Formula	C20H17NO6
InchiKey	IYGYMKDQCDOMRE-ZWKOTPCHSA-N
SMILES	CN1CCc2c([C@H]1[C@@H]1OC(=O)c3c1ccc1c3OCO1)cc1c(c2)OCO1
Inchi	InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
IUPAC	(6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
Molecular Weight	367.11
Pubchem Id	10237
Chembl Id	CHEMBL417990

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

H0Z

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
P28472	BXGT009260	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	GABRB3	Ion channel	-	-	-	-

Binding DB

50000693

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT022401	Gamma-aminobutyric acid type B receptor subunit 1	reviewed		Gabbr1	6200	-	-	-
reviewed	BXGT021402	Sigma non-opioid intracellular receptor 1	reviewed		Sigmar1	>10000	-	-	-
reviewed	BXGT009821	Histamine H1 receptor	reviewed	G-protein coupled receptor	HRH1	>10000	-	-	-
reviewed	BXGT011367	D(2) dopamine receptor	reviewed		Drd2	>10000	-	-	-
reviewed	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	>10000	-	-	-
reviewed	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	4570.88	-	-	-
reviewed	BXGT010590	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	Ion channel	GABRA2	1862.08	-	-	-
reviewed	BXGT009769	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	Ion channel	GABRA3	2818.38	-	-	-
reviewed	BXGT009557	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	Ion channel	GABRA5	4466.83	-	-	-
reviewed	BXGT013629	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	Ion channel	GABRA6	>10000	-	-	-
reviewed	BXGT008884	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed		Gabrg1	-	0.000004	-	-

CHEMBL

CHEMBL417990

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P81908	BXGT011959	Cholinesterase	reviewed	-	BCHE	Inhibition	'='	0	%
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	Activity	-	-	-
Q16445	BXGT013629	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	Ion channel	GABRA6	IC50	'='	6200	nM
P31644	BXGT009557	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	Ion channel	GABRA5	IC50	'='	6200	nM
P47869	BXGT010590	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	Ion channel	GABRA2	IC50	'='	6200	nM
P78334	BXGT011834	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	Ion channel	GABRE	IC50	'='	6200	nM
P18505	BXGT008409	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	Ion channel	GABRB1	IC50	'='	6200	nM
Q8N1C3	BXGT018498	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	Ion channel	GABRG1	IC50	'='	6200	nM
O14764	BXGT004094	Gamma-aminobutyric acid receptor subunit delta	reviewed	Ion channel	GABRD	IC50	'='	6200	nM
O00591	BXGT003939	Gamma-aminobutyric acid receptor subunit pi	reviewed	Ion channel	GABRP	IC50	'='	6200	nM
P34903	BXGT009769	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	Ion channel	GABRA3	IC50	'='	6200	nM
Q9UN88	BXGT021783	Gamma-aminobutyric acid receptor subunit theta	reviewed	Ion channel	GABRQ	IC50	'='	6200	nM
Q99928	BXGT019975	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	Ion channel	GABRG3	IC50	'='	6200	nM
P48169	BXGT010622	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	Ion channel	GABRA4	IC50	'='	6200	nM
P28472	BXGT009260	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	Ion channel	GABRB3	IC50	'='	6200	nM
P18507	BXGT008411	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	Ion channel	GABRG2	IC50	'='	6200	nM
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	IC50	'='	6200	nM
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	IC50	'='	6200	nM
Q9ES14	BXGT020314	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	-	Gabre	Displacement	'='	-1	%
Q91ZM7	BXGT019327	GABA theta subunit	unreviewed	-	Gabrq	Displacement	'='	-1	%
P63138	BXGT011502	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	-	Gabrb2	Displacement	'='	-1	%
P63079	BXGT011491	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	-	Gabrb3	Displacement	'='	-1	%
P62813	BXGT011460	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	-	Gabra1	Displacement	'='	-1	%
P30191	BXGT009410	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	-	Gabra6	Displacement	'='	-1	%
P28473	BXGT009261	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	-	Gabrg3	Displacement	'='	-1	%
P28471	BXGT009259	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	-	Gabra4	Displacement	'='	-1	%
P23576	BXGT008885	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	-	Gabra2	Displacement	'='	-1	%
P23574	BXGT008884	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	-	Gabrg1	Displacement	'='	-1	%
P20236	BXGT008551	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	-	Gabra3	Displacement	'='	-1	%
P19969	BXGT008536	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	-	Gabra5	Displacement	'='	-1	%
P18508	BXGT008412	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	-	Gabrg2	Displacement	'='	-1	%
P18506	BXGT008410	Gamma-aminobutyric acid receptor subunit delta	reviewed	-	Gabrd	Displacement	'='	-1	%
P15431	BXGT008122	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	-	Gabrb1	Displacement	'='	-1	%
O09028	BXGT004049	Gamma-aminobutyric acid receptor subunit pi	reviewed	-	Gabrp	Displacement	'='	-1	%
P63138	BXGT011502	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	-	Gabrb2	GABA current	'='	-100	%
P62813	BXGT011460	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	-	Gabra1	GABA current	'='	-100	%
P18508	BXGT008412	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	-	Gabrg2	GABA current	'='	-100	%
Q9NY46	BXGT021248	Sodium channel protein type 3 subunit alpha	reviewed	Ion channel	SCN3A	Inhibition	'='	1	%
Q99250	BXGT019913	Sodium channel protein type 2 subunit alpha	reviewed	Ion channel	SCN2A	Inhibition	'='	1	%
P35498	BXGT009838	Sodium channel protein type 1 subunit alpha	reviewed	Ion channel	SCN1A	Inhibition	'='	1	%
Q9ES14	BXGT020314	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	-	Gabre	Relative affinity	'='	0	-
Q91ZM7	BXGT019327	GABA theta subunit	unreviewed	-	Gabrq	Relative affinity	'='	0	-
P63138	BXGT011502	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	-	Gabrb2	Relative affinity	'='	0	-
P63079	BXGT011491	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	-	Gabrb3	Relative affinity	'='	0	-
P62813	BXGT011460	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	-	Gabra1	Relative affinity	'='	0	-
P30191	BXGT009410	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	-	Gabra6	Relative affinity	'='	0	-
P28473	BXGT009261	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	-	Gabrg3	Relative affinity	'='	0	-
P28471	BXGT009259	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	-	Gabra4	Relative affinity	'='	0	-
P23576	BXGT008885	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	-	Gabra2	Relative affinity	'='	0	-
P23574	BXGT008884	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	-	Gabrg1	Relative affinity	'='	0	-
P20236	BXGT008551	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	-	Gabra3	Relative affinity	'='	0	-
P19969	BXGT008536	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	-	Gabra5	Relative affinity	'='	0	-
P18508	BXGT008412	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	-	Gabrg2	Relative affinity	'='	0	-
P18506	BXGT008410	Gamma-aminobutyric acid receptor subunit delta	reviewed	-	Gabrd	Relative affinity	'='	0	-
P15431	BXGT008122	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	-	Gabrb1	Relative affinity	'='	0	-
O09028	BXGT004049	Gamma-aminobutyric acid receptor subunit pi	reviewed	-	Gabrp	Relative affinity	'='	0	-
Q16445	BXGT013629	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	Ion channel	GABRA6	IC50	'='	15000	nM
P31644	BXGT009557	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	Ion channel	GABRA5	IC50	'='	15000	nM
P47869	BXGT010590	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	Ion channel	GABRA2	IC50	'='	15000	nM
P78334	BXGT011834	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	Ion channel	GABRE	IC50	'='	15000	nM
P18505	BXGT008409	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	Ion channel	GABRB1	IC50	'='	15000	nM
Q8N1C3	BXGT018498	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	Ion channel	GABRG1	IC50	'='	15000	nM
O14764	BXGT004094	Gamma-aminobutyric acid receptor subunit delta	reviewed	Ion channel	GABRD	IC50	'='	15000	nM
O00591	BXGT003939	Gamma-aminobutyric acid receptor subunit pi	reviewed	Ion channel	GABRP	IC50	'='	15000	nM
P34903	BXGT009769	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	Ion channel	GABRA3	IC50	'='	15000	nM
Q9UN88	BXGT021783	Gamma-aminobutyric acid receptor subunit theta	reviewed	Ion channel	GABRQ	IC50	'='	15000	nM
Q99928	BXGT019975	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	Ion channel	GABRG3	IC50	'='	15000	nM
P48169	BXGT010622	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	Ion channel	GABRA4	IC50	'='	15000	nM
P28472	BXGT009260	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	Ion channel	GABRB3	IC50	'='	15000	nM
P18507	BXGT008411	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	Ion channel	GABRG2	IC50	'='	15000	nM
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	IC50	'='	15000	nM
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	IC50	'='	15000	nM
O42275	BXGT004559	Acetylcholinesterase	reviewed	-	ache	Inhibition	'='	20	%
Q9ES14	BXGT020314	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	-	Gabre	Displacement	'='	7	%
Q91ZM7	BXGT019327	GABA theta subunit	unreviewed	-	Gabrq	Displacement	'='	7	%
P63138	BXGT011502	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	-	Gabrb2	Displacement	'='	7	%
P63079	BXGT011491	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	-	Gabrb3	Displacement	'='	7	%
P62813	BXGT011460	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	-	Gabra1	Displacement	'='	7	%
P30191	BXGT009410	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	-	Gabra6	Displacement	'='	7	%
P28473	BXGT009261	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	-	Gabrg3	Displacement	'='	7	%
P28471	BXGT009259	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	-	Gabra4	Displacement	'='	7	%
P23576	BXGT008885	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	-	Gabra2	Displacement	'='	7	%
P23574	BXGT008884	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	-	Gabrg1	Displacement	'='	7	%
P20236	BXGT008551	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	-	Gabra3	Displacement	'='	7	%
P19969	BXGT008536	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	-	Gabra5	Displacement	'='	7	%
P18508	BXGT008412	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	-	Gabrg2	Displacement	'='	7	%
P18506	BXGT008410	Gamma-aminobutyric acid receptor subunit delta	reviewed	-	Gabrd	Displacement	'='	7	%
P15431	BXGT008122	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	-	Gabrb1	Displacement	'='	7	%
O09028	BXGT004049	Gamma-aminobutyric acid receptor subunit pi	reviewed	-	Gabrp	Displacement	'='	7	%
O75496	BXGT005132	Geminin	reviewed	-	GMNN	Potency	-	2310	nM
Q16445	BXGT013629	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	Ion channel	GABRA6	IC50	'='	44000	nM
P31644	BXGT009557	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	Ion channel	GABRA5	IC50	'='	44000	nM
P47869	BXGT010590	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	Ion channel	GABRA2	IC50	'='	44000	nM
P78334	BXGT011834	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	Ion channel	GABRE	IC50	'='	44000	nM
P18505	BXGT008409	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	Ion channel	GABRB1	IC50	'='	44000	nM
Q8N1C3	BXGT018498	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	Ion channel	GABRG1	IC50	'='	44000	nM
O14764	BXGT004094	Gamma-aminobutyric acid receptor subunit delta	reviewed	Ion channel	GABRD	IC50	'='	44000	nM
O00591	BXGT003939	Gamma-aminobutyric acid receptor subunit pi	reviewed	Ion channel	GABRP	IC50	'='	44000	nM
P34903	BXGT009769	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	Ion channel	GABRA3	IC50	'='	44000	nM
Q9UN88	BXGT021783	Gamma-aminobutyric acid receptor subunit theta	reviewed	Ion channel	GABRQ	IC50	'='	44000	nM
Q99928	BXGT019975	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	Ion channel	GABRG3	IC50	'='	44000	nM
P48169	BXGT010622	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	Ion channel	GABRA4	IC50	'='	44000	nM
P28472	BXGT009260	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	Ion channel	GABRB3	IC50	'='	44000	nM
P18507	BXGT008411	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	Ion channel	GABRG2	IC50	'='	44000	nM
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	IC50	'='	44000	nM
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	IC50	'='	44000	nM
Q9ES14	BXGT020314	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	-	Gabre	Displacement	'='	45	%
Q91ZM7	BXGT019327	GABA theta subunit	unreviewed	-	Gabrq	Displacement	'='	45	%
P63138	BXGT011502	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	-	Gabrb2	Displacement	'='	45	%
P63079	BXGT011491	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	-	Gabrb3	Displacement	'='	45	%
P62813	BXGT011460	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	-	Gabra1	Displacement	'='	45	%
P30191	BXGT009410	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	-	Gabra6	Displacement	'='	45	%
P28473	BXGT009261	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	-	Gabrg3	Displacement	'='	45	%
P28471	BXGT009259	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	-	Gabra4	Displacement	'='	45	%
P23576	BXGT008885	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	-	Gabra2	Displacement	'='	45	%
P23574	BXGT008884	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	-	Gabrg1	Displacement	'='	45	%
P20236	BXGT008551	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	-	Gabra3	Displacement	'='	45	%
P19969	BXGT008536	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	-	Gabra5	Displacement	'='	45	%
P18508	BXGT008412	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	-	Gabrg2	Displacement	'='	45	%
P18506	BXGT008410	Gamma-aminobutyric acid receptor subunit delta	reviewed	-	Gabrd	Displacement	'='	45	%
P15431	BXGT008122	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	-	Gabrb1	Displacement	'='	45	%
O09028	BXGT004049	Gamma-aminobutyric acid receptor subunit pi	reviewed	-	Gabrp	Displacement	'='	45	%
P23574	BXGT008884	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	-	Gabrg1	IC50	'='	3800	nM
P83916	BXGT012025	Chromobox protein homolog 1	reviewed	Epigenetic regulator	CBX1	Potency	-	79432	nM
Q96KQ7	BXGT019687	Histone-lysine N-methyltransferase EHMT2	reviewed	Epigenetic regulator	EHMT2	Potency	-	25118	nM
O89049	BXGT005293	Thioredoxin reductase 1, cytoplasmic	reviewed	-	Txnrd1	Potency	-	70794	nM
O95149	BXGT005350	Snurportin-1	reviewed	-	SNUPN	Potency	-	70794	nM
Q14974	BXGT013516	Importin subunit beta-1	reviewed	Transporter	KPNB1	Potency	-	70794	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF01752	Corydalis decumbens	Corydalis decumbens	Medicinal Plant
BXGF04911	Corydalis bungeanae herba	Corydalis bungeanae herba	Others
BXGF04912	Corydalis rhizoma	Corydalis rhizoma	Others
BXGF05206	Corydalis gigantea	Corydalis gigantea	Medicinal Plant
BXGF05994	Corydalis yanhusuo	Corydalis yanhusuo	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}