Showing entry for Oxysterols receptor LXR-alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013315
Protein NameOxysterols receptor LXR-alpha
Uniport IdQ13133
GeneNR1H3
Gene Id10062
DomainHormone_recep; zf-C4
Pfam PF00104   PF00105  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04931 Insulin resistance
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04932 Non-alcoholic fatty liver disease (NAFLD)
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0043277 apoptotic cell clearance
Biological Process GO:0030154 cell differentiation
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0055088 lipid homeostasis
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0010887 negative regulation of cholesterol storage
Biological Process GO:0120163 negative regulation of cold-induced thermogenesis
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
Biological Process GO:0032369 negative regulation of lipid transport
Biological Process GO:0043031 negative regulation of macrophage activation
Biological Process GO:0010745 negative regulation of macrophage derived foam cell differentiation
Biological Process GO:0090188 negative regulation of pancreatic juice secretion
Biological Process GO:0048550 negative regulation of pinocytosis
Biological Process GO:1903573 negative regulation of response to endoplasmic reticulum stress
Biological Process GO:0090341 negative regulation of secretion of lysosomal enzymes
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0036151 phosphatidylcholine acyl-chain remodeling
Biological Process GO:0032270 positive regulation of cellular protein metabolic process
Biological Process GO:0010875 positive regulation of cholesterol efflux
Biological Process GO:0032376 positive regulation of cholesterol transport
Biological Process GO:0045723 positive regulation of fatty acid biosynthetic process
Biological Process GO:0051006 positive regulation of lipoprotein lipase activity
Biological Process GO:0010870 positive regulation of receptor biosynthetic process
Biological Process GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0010867 positive regulation of triglyceride biosynthetic process
Biological Process GO:0042752 regulation of circadian rhythm
Biological Process GO:2000325 regulation of nuclear receptor transcription coactivator activity
Biological Process GO:0032570 response to progesterone
Biological Process GO:0055092 sterol homeostasis
Biological Process GO:0006367 transcription initiation from RNA polymerase II promoter
Biological Process GO:0070328 triglyceride homeostasis
molecular function GO:0015485 cholesterol binding
molecular function GO:0003677 DNA binding
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0004879 nuclear receptor activity
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:0038023 signaling receptor activity
molecular function GO:0032810 sterol response element binding
molecular function GO:0008134 transcription factor binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0043235 receptor complex
cellular component GO:0090575 RNA polymerase II transcription regulator complex
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-1989781 PPARA activates gene expression
R-HSA-382551 Transport of small molecules
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-556833 Metabolism of lipids
R-HSA-8866427 VLDLR internalisation and degradation
R-HSA-8964043 Plasma lipoprotein clearance
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-HSA-9031525 NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
R-HSA-9031528 NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
R-HSA-9632974 NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003125 BXGD000179 Anorexia Nervosa Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017920 BXGD001151 Glycogen Storage Disease Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025322 BXGD001863 Premature Menopause Female Urogenital Diseases and Pregnancy Complications
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040420 BXGD002861 Tonometry
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0085083 BXGD003120 Ovarian Hyperstimulation Syndrome Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0151814 BXGD003479 Coronary Occlusion Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0156369 BXGD003853 Uterine Polyp Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0201976 BXGD004063 Creatinine measurement, serum (procedure)
C0202236 BXGD004086 Triglycerides measurement
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677932 BXGD009736 Progressive Neoplastic Disease
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0947622 BXGD011493 Cholecystolithiasis Digestive System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1153706 BXGD011769 Endometrial adenocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306214 BXGD012356 ACTH-Secreting Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1827293 BXGD013768 Carcinoma of urinary bladder, invasive Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1847835 BXGD014892 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) Skin and Connective Tissue Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2750440 BXGD017660 FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1
C2750441 BXGD017661 LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3150651 BXGD018316 FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2
C3539781 BXGD019086 Progressive cGVHD
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3665365 BXGD019282 Arteriosclerotic cardiovascular disease, NOS Cardiovascular Diseases
C4049446 BXGD021933 Neointimal hyperplasia
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000505 Protocatechuic acid 154.12
BXGC0001893 Cyanidin 287.24
BXGC0001962 Hesperetin 302.28
BXGC0004965 Rhein 284.22
BXGC0005624 Genistein 270.24
BXGC0007601 1,8-Cineole 154.25
BXGC0012874 Continentalic acid 302.22
BXGC0021836 Honokiol 266.13
BXGC0028602 Ergost-24(28)-Ene-3-Beta,5-Alpha,6-Beta,7-Beta-Tetrol 448.36
BXGC0029253 Desmosterol 384.34
BXGC0030597 Phloroglucinaldehyde 154.03
BXGC0031435 Guttiferone I 670.42
BXGC0032125 (-)-Acanthoic Acid 302.22
BXGC0035226 Betulinic Acid 456.36
BXGC0037954 Pimaric Acid 302.22
BXGC0038316 Cholesterol 386.35
BXGC0041132 Duvoglustat 163.08
BXGC0041564 Abietic Acid 302.22
BXGC0048222 3,23-Dioxocycloarta-24-ene-26-oic acid 468.32
BXGC0050155 Riccardi C 424.17
BXGC0051342 Valerenic Acid 234.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein