Showing entry for Neuronal acetylcholine receptor subunit beta-4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009482
Protein NameNeuronal acetylcholine receptor subunit beta-4
Uniport IdP30926
GeneCHRNB4
Gene Id1143
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04725 Cholinergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001508 action potential
Biological Process GO:0035095 behavioral response to nicotine
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0006811 ion transport
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0050877 nervous system process
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0051971 positive regulation of transmission of nerve impulse
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0046928 regulation of neurotransmitter secretion
Biological Process GO:0006940 regulation of smooth muscle contraction
Biological Process GO:0007165 signal transduction
Biological Process GO:0006939 smooth muscle contraction
Biological Process GO:0007271 synaptic transmission, cholinergic
Biological Process GO:0060084 synaptic transmission involved in micturition
molecular function GO:0042166 acetylcholine binding
molecular function GO:0022848 acetylcholine-gated cation-selective channel activity
molecular function GO:0015464 acetylcholine receptor activity
molecular function GO:0008144 drug binding
molecular function GO:0015276 ligand-gated ion channel activity
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:0044877 protein-containing complex binding
cellular component GO:0005892 acetylcholine-gated channel complex
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0035579 specific granule membrane
cellular component GO:0045202 synapse
cellular component GO:0070821 tertiary granule membrane
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-181431 Acetylcholine binding and downstream events
R-HSA-622323 Presynaptic nicotinic acetylcholine receptors
R-HSA-622327 Postsynaptic nicotinic acetylcholine receptors
R-HSA-629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012833 BXGD000795 Dizziness Pathological Conditions, Signs and Symptoms
C0016529 BXGD001068 Forced expiratory volume function
C0022333 BXGD001534 Jacksonian Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0034072 BXGD002459 Cor pulmonale Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0038586 BXGD002772 Substance Use Disorders Chemically-Induced Disorders; Mental Disorders
C0038587 BXGD002773 Substance Withdrawal Syndrome Chemically-Induced Disorders; Mental Disorders
C0040332 BXGD002858 Tobacco Dependence Chemically-Induced Disorders; Mental Disorders
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0086189 BXGD003268 Drug Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0087169 BXGD003321 Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149958 BXGD003395 Complex partial seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178417 BXGD004025 Anhedonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0233488 BXGD004583 Feeling despair Behavior and Behavior Mechanisms
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234535 BXGD004688 Clonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0237123 BXGD004845 Alcohol or Other Drugs use
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270844 BXGD006115 Tonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0422850 BXGD008457 Seizures, Somatosensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422852 BXGD008458 Seizures, Auditory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422853 BXGD008459 Olfactory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422854 BXGD008460 Gustatory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422855 BXGD008461 Vertiginous seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0751056 BXGD010306 Non-epileptic convulsion Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751110 BXGD010318 Single Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751123 BXGD010326 Atonic Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751494 BXGD010472 Convulsive Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751496 BXGD010474 Seizures, Sensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1720824 BXGD013686 Sudden Cardiac Arrest Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C3495874 BXGD019008 Nonepileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3548479 BXGD019120 response to bronchodilator
C4025272 BXGD021615 Peripheral arterial stenosis
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317123 BXGD022727 Myoclonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505436 BXGD022962 Generalized Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0000437 Nonane 128.26
BXGC0000994 Liriodenine 275.26
BXGC0002796 Nicotine 162.23
BXGC0003102 Acetylcholine 146.21
BXGC0030005 Cinnamolide 234.16
BXGC0031522 Microgrewiapine A 263.22
BXGC0033472 7'-(3',4'-dihydroxyphenyl)-N-((4-methoxyphenyl)ethyl)propenamide 313.13
BXGC0033981 Cyfusine 176.09
BXGC0035631 cytisine 190.11
BXGC0035935 microcosamine A 249.21
BXGC0042510 Fluoxetine 309.13
BXGC0044162 Polygodial 234.16
BXGC0045087 microgrewiapine B 279.22
BXGC0045088 microgrewiapine C 279.22
BXGC0045089 Microgrewiapine A 3-Acetate 305.24
BXGC0050754 Cytisine 190.11
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein