Showing entry for Acetylcholine receptor subunit delta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012907
Protein NameAcetylcholine receptor subunit delta
Uniport IdQ07001
GeneCHRND
Gene Id1144
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0006936 muscle contraction
Biological Process GO:0050881 musculoskeletal movement
Biological Process GO:0050877 nervous system process
Biological Process GO:0050905 neuromuscular process
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0007165 signal transduction
Biological Process GO:0003009 skeletal muscle contraction
Biological Process GO:0048630 skeletal muscle tissue growth
molecular function GO:0042166 acetylcholine binding
molecular function GO:0022848 acetylcholine-gated cation-selective channel activity
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:0004888 transmembrane signaling receptor activity
molecular function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
cellular component GO:0005892 acetylcholine-gated channel complex
cellular component GO:0005829 cytosol
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099060 integral component of postsynaptic specialization membrane
cellular component GO:0031594 neuromuscular junction
cellular component GO:0043005 neuron projection
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-181431 Acetylcholine binding and downstream events
R-HSA-622323 Presynaptic nicotinic acetylcholine receptors
R-HSA-622327 Postsynaptic nicotinic acetylcholine receptors
R-HSA-629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0010520 BXGD000675 Cyanosis Pathological Conditions, Signs and Symptoms
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0012569 BXGD000777 Diplopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0013144 BXGD000800 Drowsiness Mental Disorders
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0013604 BXGD000859 Edema Pathological Conditions, Signs and Symptoms
C0015469 BXGD000996 Facial paralysis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0020224 BXGD001366 Polyhydramnios Female Urogenital Diseases and Pregnancy Complications
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0022972 BXGD001596 Lambert-Eaton Myasthenic Syndrome Neoplasms; Immune System Diseases; Nervous System Diseases
C0024591 BXGD001789 Malignant hyperpyrexia due to anesthesia Pathological Conditions, Signs and Symptoms
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0026896 BXGD001946 Myasthenia Gravis Neoplasms; Immune System Diseases; Nervous System Diseases
C0027868 BXGD002053 Neuromuscular Diseases Nervous System Diseases
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0085619 BXGD003207 Orthopnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0085623 BXGD003210 Akinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0206620 BXGD004187 Lymphangioma, Cystic Neoplasms
C0231807 BXGD004524 Dyspnea on exertion Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0232466 BXGD004543 Feeding difficulties
C0234544 BXGD004689 Todd Paralysis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0239234 BXGD004974 Low set ears
C0239594 BXGD004987 Short finger
C0240479 BXGD005039 Neck muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0265783 BXGD005575 Congenital hypoplasia of lung Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0333068 BXGD006920 Flexion contracture Musculoskeletal Diseases
C0424503 BXGD008532 Dysmorphic facies
C0426818 BXGD008586 Thin rib
C0427063 BXGD008602 Shoulder girdle weakness
C0432185 BXGD008730 Aplasia of muscle Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0476408 BXGD008994 Reduced vital capacity
C0522224 BXGD009198 Paralysed Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0541794 BXGD009262 Skeletal muscle atrophy
C0549225 BXGD009364 Myasthenic Syndrome
C0678230 BXGD009750 Congenital Epicanthus
C0746674 BXGD010147 Generalized muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0751401 BXGD010427 Ophthalmoparesis Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0751882 BXGD010626 Myasthenic Syndromes, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0751883 BXGD010627 Congenital Myasthenic Syndromes, Postsynaptic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0751884 BXGD010628 Congenital Myasthenic Syndromes, Presynaptic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0751885 BXGD010629 Myasthenic Syndromes, Congenital, Slow Channel Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1276035 BXGD012100 Pena-Shokeir syndrome type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1390474 BXGD012969 Increased susceptibility to fractures
C1834536 BXGD013977 Weakness of the intrinsic hand muscles
C1837092 BXGD014197 Myasthenic Syndrome, Congenital, with Facial Dysmorphism, associated with Acetylcholine Receptor Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1837098 BXGD014198 Easy fatigability
C1837122 BXGD014200 Myasthenic Syndrome, Congenital, Fast-Channel Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1837658 BXGD014257 Gross motor development delay Mental Disorders
C1842876 BXGD014542 Depressed nasal ridge
C1843637 BXGD014597 Neck flexor weakness
C1844548 BXGD014642 Hypoplastic finger
C1853952 BXGD015371 Decreased miniature endplate potentials
C1854387 BXGD015396 Type 1 muscle fiber predominance
C1854678 BXGD015420 MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1866934 BXGD016427 Reduced tendon reflexes Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1867448 BXGD016456 Multiple pterygia Eye Diseases
C2228039 BXGD016957 Ankle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C2230441 BXGD016958 Triceps weakness
C2267233 BXGD017017 Neonatal Hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2830004 BXGD017804 Somnolence Pathological Conditions, Signs and Symptoms
C3151523 BXGD018440 Abnormal cervical curvature
C3151525 BXGD018441 Hypoplastic heart Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C3277226 BXGD018711 Restrictive ventilatory defect
C3278509 BXGD018742 Spinal fusion
C3279725 BXGD018774 Hip flexor weakness
C3808046 BXGD019538 Breathing dysregulation
C4015465 BXGD020208 Thoracic kyphoscoliosis
C4021726 BXGD020735 EMG: myopathic abnormalities Musculoskeletal Diseases; Nervous System Diseases
C4021728 BXGD020737 EMG: decremental response of compound muscle action potential to repetitive nerve stimulation
C4022584 BXGD020925 Fatigable weakness of neck muscles
C4022587 BXGD020928 Fatigable weakness of respiratory muscles
C4024601 BXGD021334 Weakness of long finger extensor muscles
C4025615 BXGD021696 Decreased size of nerve terminals
C4073190 BXGD022064 Abnormality of masticatory muscle
C4084823 BXGD022108 MYASTHENIC SYNDROME, CONGENITAL, 1A, SLOW-CHANNEL
C4225370 BXGD022246 MYASTHENIC SYNDROME, CONGENITAL, 3C, ASSOCIATED WITH ACETYLCHOLINE RECEPTOR DEFICIENCY
C4225371 BXGD022247 MYASTHENIC SYNDROME, CONGENITAL, 3B, FAST-CHANNEL
C4225372 BXGD022248 MYASTHENIC SYNDROME, CONGENITAL, 3A, SLOW-CHANNEL
C4552811 BXGD023526 Generalized Muscle Weakness, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002796 Nicotine 162.23
BXGC0050754 Cytisine 190.11
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein