Showing entry for Neuronal acetylcholine receptor subunit alpha-7


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009926
Protein NameNeuronal acetylcholine receptor subunit alpha-7
Uniport IdP36544
GeneCHRNA7
Gene Id1139;89832
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04725 Cholinergic synapse
6. Human Diseases 6.5 Substance dependence hsa05033 Nicotine addiction
6. Human Diseases 6.1 Cancers: Overview hsa05204 Chemical carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0095500 acetylcholine receptor signaling pathway
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0008306 associative learning
Biological Process GO:0042113 B cell activation
Biological Process GO:0048149 behavioral response to ethanol
Biological Process GO:0035095 behavioral response to nicotine
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0050890 cognition
Biological Process GO:0140059 dendrite arborization
Biological Process GO:0097061 dendritic spine organization
Biological Process GO:0006897 endocytosis
Biological Process GO:0030317 flagellated sperm motility
Biological Process GO:0060112 generation of ovulation cycle rhythm
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0006811 ion transport
Biological Process GO:0007611 learning or memory
Biological Process GO:0007613 memory
Biological Process GO:0098815 modulation of excitatory postsynaptic potential
Biological Process GO:1902430 negative regulation of amyloid-beta formation
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0032691 negative regulation of interleukin-1 beta production
Biological Process GO:0032715 negative regulation of interleukin-6 production
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0032720 negative regulation of tumor necrosis factor production
Biological Process GO:0050877 nervous system process
Biological Process GO:1902004 positive regulation of amyloid-beta formation
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:1905920 positive regulation of CoA-transferase activity
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:2000463 positive regulation of excitatory postsynaptic potential
Biological Process GO:0001988 positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
Biological Process GO:1900273 positive regulation of long-term synaptic potentiation
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0051247 positive regulation of protein metabolic process
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:1905906 regulation of amyloid fibril formation
Biological Process GO:1902991 regulation of amyloid precursor protein catabolic process
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:1901214 regulation of neuron death
Biological Process GO:0014061 regulation of norepinephrine secretion
Biological Process GO:0032225 regulation of synaptic transmission, dopaminergic
Biological Process GO:1905144 response to acetylcholine
Biological Process GO:1904645 response to amyloid-beta
Biological Process GO:0009409 response to cold
Biological Process GO:0032094 response to food
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0035094 response to nicotine
Biological Process GO:0050893 sensory processing
Biological Process GO:0007614 short-term memory
Biological Process GO:0007165 signal transduction
Biological Process GO:0050808 synapse organization
Biological Process GO:0007271 synaptic transmission, cholinergic
Biological Process GO:0042110 T cell activation
molecular function GO:0042166 acetylcholine binding
molecular function GO:0022848 acetylcholine-gated cation-selective channel activity
molecular function GO:0015464 acetylcholine receptor activity
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0005262 calcium channel activity
molecular function GO:0017081 chloride channel regulator activity
molecular function GO:0005216 ion channel activity
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0015643 toxic substance binding
cellular component GO:0005892 acetylcholine-gated channel complex
cellular component GO:0016324 apical plasma membrane
cellular component GO:0030673 axolemma
cellular component GO:0098981 cholinergic synapse
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099060 integral component of postsynaptic specialization membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0044853 plasma membrane raft
cellular component GO:0098794 postsynapse
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-181431 Acetylcholine binding and downstream events
R-HSA-622327 Postsynaptic nicotinic acetylcholine receptors
R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011269 BXGD000710 Dementia, Vascular Nervous System Diseases; Mental Disorders; Cardiovascular Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0025500 BXGD001874 Mesothelioma Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0242966 BXGD005201 Systemic Inflammatory Response Syndrome Pathological Conditions, Signs and Symptoms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0270853 BXGD006119 Juvenile Myoclonic Epilepsy Nervous System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0424101 BXGD008519 Inattention
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1839839 BXGD014416 MAJOR AFFECTIVE DISORDER 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders
C1852197 BXGD015264 MAJOR AFFECTIVE DISORDER 1 Mental Disorders
C1970943 BXGD016852 MAJOR AFFECTIVE DISORDER 4 Mental Disorders
C1970945 BXGD016853 MAJOR AFFECTIVE DISORDER 6 Mental Disorders
C2700438 BXGD017469 MAJOR AFFECTIVE DISORDER 7 Mental Disorders
C2700439 BXGD017470 MAJOR AFFECTIVE DISORDER 8 Mental Disorders
C2700440 BXGD017471 MAJOR AFFECTIVE DISORDER 9 Mental Disorders
C3696898 BXGD019348 Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Nervous System Diseases
C4285693 BXGD022446 HIV-associated neurocognitive disorder Infections; Immune System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000195 O-Methylcorypalline 207.27
BXGC0000226 Glycine 75.07
BXGC0000297 (E)-2,4,4'-Trihydroxychalcone 256.25
BXGC0000409 Choline 104.17
BXGC0000434 Ethanol 46.07
BXGC0000470 Chalconaringenin 272.25
BXGC0001451 (S)-Laudanosine 357.44
BXGC0001488 Erysodine 299.36
BXGC0002765 Ammonia 17.03
BXGC0002796 Nicotine 162.23
BXGC0003102 Acetylcholine 146.21
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0005707 Trimethylamine 59.11
BXGC0005867 Serotonin 176.22
BXGC0008707 Isoliquiritigenin 256.25
BXGC0012228 Vitamin D 384.64
BXGC0016637 6-Methoxy-2-Methyl-3,4-Dihydro-1H-Isoquinolin-7-Ol 193.11
BXGC0021495 Dl-Anabasine 162.12
BXGC0024132 1H-Indol-5-Ol 133.05
BXGC0025485 Transtorine 189.04
BXGC0028885 Secobarbital 238.13
BXGC0029722 2,2',4'-Trihydroxychalcone 256.07
BXGC0030005 Cinnamolide 234.16
BXGC0035349 (+)-Crispine A 233.14
BXGC0038169 (-)-Lobeline 337.2
BXGC0040150 Cannabidiol 314.22
BXGC0041195 Boldine 327.15
BXGC0042869 Xanthoplanine 356.19
BXGC0044162 Polygodial 234.16
BXGC0046653 (+/-)Nicotine 162.12
BXGC0049630 6-Methyl-7,8-Dihydro-5H-[1,3]Dioxolo[4,5-G]Isoquinoline 191.09
BXGC0050754 Cytisine 190.11
BXGC0050816 Galantamine 287.15
BXGC0052646 Tubocurarine 609.3
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein