Showing entry for Neuronal acetylcholine receptor subunit alpha-3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009616
Protein NameNeuronal acetylcholine receptor subunit alpha-3
Uniport IdP32297
GeneCHRNA3
Gene Id1136
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04725 Cholinergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0095500 acetylcholine receptor signaling pathway
Biological Process GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
Biological Process GO:0035095 behavioral response to nicotine
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0060079 excitatory postsynaptic potential
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0006811 ion transport
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0007399 nervous system development
Biological Process GO:0050877 nervous system process
Biological Process GO:0014056 regulation of acetylcholine secretion, neurotransmission
Biological Process GO:0048814 regulation of dendrite morphogenesis
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0006940 regulation of smooth muscle contraction
Biological Process GO:1905144 response to acetylcholine
Biological Process GO:0007165 signal transduction
Biological Process GO:0007271 synaptic transmission, cholinergic
Biological Process GO:0060084 synaptic transmission involved in micturition
molecular function GO:0042166 acetylcholine binding
molecular function GO:0022848 acetylcholine-gated cation-selective channel activity
molecular function GO:0015464 acetylcholine receptor activity
molecular function GO:0015276 ligand-gated ion channel activity
molecular function GO:0030594 neurotransmitter receptor activity
cellular component GO:0005892 acetylcholine-gated channel complex
cellular component GO:0030425 dendrite
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0044853 plasma membrane raft
cellular component GO:0014069 postsynaptic density
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-181431 Acetylcholine binding and downstream events
R-HSA-622323 Presynaptic nicotinic acetylcholine receptors
R-HSA-622327 Postsynaptic nicotinic acetylcholine receptors
R-HSA-629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0006868 BXGD000415 Cannabis Abuse Chemically-Induced Disorders; Mental Disorders
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008074 BXGD000519 Child Development Disorders, Pervasive Mental Disorders
C0008677 BXGD000560 Bronchitis, Chronic Infections; Respiratory Tract Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0012833 BXGD000795 Dizziness Pathological Conditions, Signs and Symptoms
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013170 BXGD000802 Drug habituation Chemically-Induced Disorders; Mental Disorders
C0013363 BXGD000818 Dysautonomia Nervous System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0016529 BXGD001068 Forced expiratory volume function
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0022333 BXGD001534 Jacksonian Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0034072 BXGD002459 Cor pulmonale Cardiovascular Diseases
C0035227 BXGD002514 Respiratory Function Tests
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0040332 BXGD002858 Tobacco Dependence Chemically-Induced Disorders; Mental Disorders
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0085129 BXGD003128 Bronchial Hyperreactivity Respiratory Tract Diseases
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0085762 BXGD003251 Alcohol abuse Chemically-Induced Disorders; Mental Disorders
C0087169 BXGD003321 Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149958 BXGD003395 Complex partial seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0162701 BXGD003978 Polysomnography
C0221757 BXGD004472 alpha 1-Antitrypsin Deficiency Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0231921 BXGD004530 Pulmonary function
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234535 BXGD004688 Clonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0237123 BXGD004845 Alcohol or Other Drugs use
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242596 BXGD005181 Neoplasm, Residual Pathological Conditions, Signs and Symptoms; Neoplasms
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270844 BXGD006115 Tonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278987 BXGD006620 Metastatic non-small cell lung cancer Neoplasms
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0280217 BXGD006720 stage, non-small cell lung cancer Neoplasms; Respiratory Tract Diseases
C0281899 BXGD006788 Prolapsed lumbar disc Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0376384 BXGD007995 Nicotine Use Disorder Chemically-Induced Disorders; Mental Disorders
C0422850 BXGD008457 Seizures, Somatosensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422852 BXGD008458 Seizures, Auditory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422853 BXGD008459 Olfactory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422854 BXGD008460 Gustatory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422855 BXGD008461 Vertiginous seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0523465 BXGD009209 Serum albumin measurement
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0600260 BXGD009701 Lung Diseases, Obstructive Respiratory Tract Diseases
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0728877 BXGD009918 Serum albumin level
C0730607 BXGD009967 Severe chronic obstructive pulmonary disease Respiratory Tract Diseases
C0751056 BXGD010306 Non-epileptic convulsion Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751110 BXGD010318 Single Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751123 BXGD010326 Atonic Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751494 BXGD010472 Convulsive Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751496 BXGD010474 Seizures, Sensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0815107 BXGD010861 psychological distress
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1314691 BXGD012388 Age at menarche Behavior and Behavior Mechanisms
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1842981 BXGD014547 NEUROTICISM Behavior and Behavior Mechanisms
C1861063 BXGD016011 TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1968949 BXGD016744 Cakut Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3160731 BXGD018470 Pulmonary function (finding)
C3495874 BXGD019008 Nonepileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3548479 BXGD019120 response to bronchodilator
C3696898 BXGD019348 Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Nervous System Diseases
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4025272 BXGD021615 Peripheral arterial stenosis
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4280669 BXGD022382 Velopharyngeal dysfunction
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317123 BXGD022727 Myoclonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505436 BXGD022962 Generalized Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0000982 L-Homocysteine 135.19
BXGC0000994 Liriodenine 275.26
BXGC0002796 Nicotine 162.23
BXGC0003102 Acetylcholine 146.21
BXGC0005874 Racemethionine 149.21
BXGC0006183 L-Cystine 240.3
BXGC0030005 Cinnamolide 234.16
BXGC0031522 Microgrewiapine A 263.22
BXGC0033472 7'-(3',4'-dihydroxyphenyl)-N-((4-methoxyphenyl)ethyl)propenamide 313.13
BXGC0033981 Cyfusine 176.09
BXGC0035631 cytisine 190.11
BXGC0035935 microcosamine A 249.21
BXGC0042462 Cysteine 121.02
BXGC0042510 Fluoxetine 309.13
BXGC0044162 Polygodial 234.16
BXGC0045087 microgrewiapine B 279.22
BXGC0045088 microgrewiapine C 279.22
BXGC0045089 Microgrewiapine A 3-Acetate 305.24
BXGC0046653 (+/-)Nicotine 162.12
BXGC0050754 Cytisine 190.11
BXGC0052646 Tubocurarine 609.3
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein