Showing entry for Neuronal acetylcholine receptor subunit beta-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008341
Protein NameNeuronal acetylcholine receptor subunit beta-2
Uniport IdP17787
GeneCHRNB2
Gene Id1141
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04725 Cholinergic synapse
6. Human Diseases 6.5 Substance dependence hsa05033 Nicotine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0095500 acetylcholine receptor signaling pathway
Biological Process GO:0001508 action potential
Biological Process GO:0008306 associative learning
Biological Process GO:0042113 B cell activation
Biological Process GO:0035095 behavioral response to nicotine
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0021952 central nervous system projection neuron axonogenesis
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0050890 cognition
Biological Process GO:0001661 conditioned taste aversion
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0006811 ion transport
Biological Process GO:0021771 lateral geniculate nucleus development
Biological Process GO:0007612 learning
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0051899 membrane depolarization
Biological Process GO:0007613 memory
Biological Process GO:0045759 negative regulation of action potential
Biological Process GO:0050877 nervous system process
Biological Process GO:0021631 optic nerve morphogenesis
Biological Process GO:0030890 positive regulation of B cell proliferation
Biological Process GO:0033603 positive regulation of dopamine secretion
Biological Process GO:0032226 positive regulation of synaptic transmission, dopaminergic
Biological Process GO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep
Biological Process GO:0042320 regulation of circadian sleep/wake cycle, REM sleep
Biological Process GO:0048814 regulation of dendrite morphogenesis
Biological Process GO:0042053 regulation of dopamine metabolic process
Biological Process GO:0014059 regulation of dopamine secretion
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0051963 regulation of synapse assembly
Biological Process GO:0032225 regulation of synaptic transmission, dopaminergic
Biological Process GO:2000300 regulation of synaptic vesicle exocytosis
Biological Process GO:1905144 response to acetylcholine
Biological Process GO:0042220 response to cocaine
Biological Process GO:0045471 response to ethanol
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0035094 response to nicotine
Biological Process GO:0019233 sensory perception of pain
Biological Process GO:0007605 sensory perception of sound
Biological Process GO:0007165 signal transduction
Biological Process GO:0006939 smooth muscle contraction
Biological Process GO:0035176 social behavior
Biological Process GO:0007271 synaptic transmission, cholinergic
Biological Process GO:0060084 synaptic transmission involved in micturition
Biological Process GO:0021562 vestibulocochlear nerve development
Biological Process GO:0008542 visual learning
Biological Process GO:0007601 visual perception
molecular function GO:0042166 acetylcholine binding
molecular function GO:0022848 acetylcholine-gated cation-selective channel activity
molecular function GO:0015464 acetylcholine receptor activity
molecular function GO:0008144 drug binding
molecular function GO:0015276 ligand-gated ion channel activity
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:0044877 protein-containing complex binding
cellular component GO:0005892 acetylcholine-gated channel complex
cellular component GO:0098981 cholinergic synapse
cellular component GO:0098691 dopaminergic synapse
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099060 integral component of postsynaptic specialization membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0044853 plasma membrane raft
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-181431 Acetylcholine binding and downstream events
R-HSA-622323 Presynaptic nicotinic acetylcholine receptors
R-HSA-622327 Postsynaptic nicotinic acetylcholine receptors
R-HSA-629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0012833 BXGD000795 Dizziness Pathological Conditions, Signs and Symptoms
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014547 BXGD000927 Epilepsies, Partial Nervous System Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0020672 BXGD001461 Hypothermia, natural Pathological Conditions, Signs and Symptoms
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027497 BXGD001993 Nausea Pathological Conditions, Signs and Symptoms
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0034933 BXGD002496 Reflex, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038587 BXGD002773 Substance Withdrawal Syndrome Chemically-Induced Disorders; Mental Disorders
C0038644 BXGD002776 Sudden infant death syndrome Pathological Conditions, Signs and Symptoms
C0041671 BXGD002930 Attention Deficit Disorder Mental Disorders
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0085541 BXGD003180 Epilepsy, Frontal Lobe Nervous System Diseases
C0086189 BXGD003268 Drug Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0087169 BXGD003321 Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0151572 BXGD003442 Reflex, Corneal, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234784 BXGD004696 Reflex, Gag, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0241772 BXGD005112 Reflex, Deep Tendon, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0277839 BXGD006481 Hoffman's Reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0277850 BXGD006482 Reflex, Pendular Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278079 BXGD006494 Psychological addiction Mental Disorders; Behavior and Behavior Mechanisms
C0278211 BXGD006507 Reflex, Corneal, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0376280 BXGD007983 Anxiety States, Neurotic Mental Disorders
C0391957 BXGD008019 idiopathic epilepsy
C0391958 BXGD008020 Familial Epilepsies Nervous System Diseases
C0393671 BXGD008114 Frontal Epilepsy, Benign, Childhood Nervous System Diseases
C0393683 BXGD008118 Epilepsy, Supplementary Motor Nervous System Diseases
C0393684 BXGD008119 Epilepsy, Cingulate Nervous System Diseases
C0393688 BXGD008120 Epilepsy, Opercular Nervous System Diseases
C0431375 BXGD008677 Classical Lissencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0522345 BXGD009201 Reflex, Acoustic, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0546126 BXGD009328 Acute Confusional Senile Dementia Nervous System Diseases; Mental Disorders
C0558845 BXGD009459 Reflex, Ankle, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0558846 BXGD009460 Reflex, Triceps, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0558847 BXGD009461 Reflex, Biceps, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0576612 BXGD009529 Reflex, Anal, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0743002 BXGD010072 Abnormal Deep Tendon Reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0750900 BXGD010241 Alzheimer's Disease, Focal Onset Nervous System Diseases; Mental Disorders
C0750901 BXGD010242 Alzheimer Disease, Early Onset Nervous System Diseases; Mental Disorders
C0751468 BXGD010453 Bulbocavernosus Reflex, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751469 BXGD010454 Bulbocavernousus Reflex Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751470 BXGD010455 Palmo-Mental Reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751471 BXGD010456 Reflex, Anal, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751472 BXGD010457 Reflex, Ankle, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751473 BXGD010458 Reflex, Ankle, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751474 BXGD010459 Reflex, Biceps, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751475 BXGD010460 Reflex, Biceps, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751476 BXGD010461 Reflex, Gag, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751477 BXGD010462 Reflex, Knee, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751478 BXGD010463 Reflex, Knee, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751479 BXGD010464 Reflex, Moro, Asymmetric Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751480 BXGD010465 Reflex, Triceps, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751481 BXGD010466 Reflex, Triceps, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751508 BXGD010481 Long Sleeper Syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751509 BXGD010482 Short Sleeper Syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751510 BXGD010483 Sleep-Related Neurogenic Tachypnea Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751511 BXGD010484 Subwakefullness Syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751642 BXGD010535 Epilepsy, Anterior Fronto-Polar Nervous System Diseases
C0751643 BXGD010536 Epilepsy, Orbito-Frontal Nervous System Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1279420 BXGD012122 Anxiety neurosis (finding) Mental Disorders
C1321905 BXGD012450 Minimal Brain Dysfunction Mental Disorders
C1504404 BXGD013141 Hippocampal sclerosis
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1835905 BXGD014066 Epilepsy, Nocturnal Frontal Lobe, Type 4 Nervous System Diseases; Mental Disorders
C1854335 BXGD015393 Epilepsy, Nocturnal Frontal Lobe, Type 3 Nervous System Diseases
C3696898 BXGD019348 Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Nervous System Diseases
C4042891 BXGD021882 Sleep Wake Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0000994 Liriodenine 275.26
BXGC0001488 Erysodine 299.36
BXGC0001492 (+)-Erysotrine 313.39
BXGC0002765 Ammonia 17.03
BXGC0002796 Nicotine 162.23
BXGC0003102 Acetylcholine 146.21
BXGC0005707 Trimethylamine 59.11
BXGC0018397 beta-1,4-mannan 180.06
BXGC0021495 Dl-Anabasine 162.12
BXGC0030005 Cinnamolide 234.16
BXGC0030685 Physostigmine 275.16
BXGC0031522 Microgrewiapine A 263.22
BXGC0033472 7'-(3',4'-dihydroxyphenyl)-N-((4-methoxyphenyl)ethyl)propenamide 313.13
BXGC0035935 microcosamine A 249.21
BXGC0038169 (-)-Lobeline 337.2
BXGC0041195 Boldine 327.15
BXGC0042179 Atropine 289.17
BXGC0043587 Scopolamine 303.15
BXGC0044162 Polygodial 234.16
BXGC0045087 microgrewiapine B 279.22
BXGC0045088 microgrewiapine C 279.22
BXGC0045089 Microgrewiapine A 3-Acetate 305.24
BXGC0050754 Cytisine 190.11
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein