Showing entry for Merkel cell carcinoma


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD000439
Disease NameMerkel cell carcinoma
Disease CUI IdC0007129
MeSH Codes C04   C01  
Disease Class NameNeoplasms; Infections
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id HP:0001574   HP:0000818   HP:0002664  
Human Phenotype Ontology TermAbnormality of the integument; Abnormality of the endocrine system; Neoplasm
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00299 BXGT003905 Chloride intracellular channel protein 1 1192 reviewed Ion channel
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O14672 BXGT004081 Disintegrin and metalloproteinase domain-containing protein 10 102 reviewed
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 5609 reviewed Kinase
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O15151 BXGT004132 Protein Mdm4 4194 reviewed Nucleic acid binding
O15169 BXGT004134 Axin-1 8312 reviewed
O15350 BXGT004154 Tumor protein p73 7161 reviewed Transcription factor
O15392 BXGT004162 Baculoviral IAP repeat-containing protein 5 332 reviewed Enzyme modulator
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O60885 BXGT004906 Bromodomain-containing protein 4 23476 reviewed Epigenetic regulator
O75015 BXGT005095 Low affinity immunoglobulin gamma Fc region receptor III-B 2215 reviewed Cell adhesion
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P04278 BXGT006182 Sex hormone-binding globulin 6462 reviewed
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04629 BXGT006239 High affinity nerve growth factor receptor 4914 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05787 BXGT006385 Keratin, type II cytoskeletal 8 3856 reviewed
P06702 BXGT006476 Protein S100-A9 6280 reviewed Calcium-binding protein
P07195 BXGT006563 L-lactate dehydrogenase B chain 3945 reviewed Enzyme
P08151 BXGT006731 Zinc finger protein GLI1 2735 reviewed
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C 5788 reviewed Enzyme
P08637 BXGT006802 Low affinity immunoglobulin gamma Fc region receptor III-A 2214 reviewed Cell adhesion
P08670 BXGT006810 Vimentin 7431 reviewed
P09104 BXGT006856 Gamma-enolase 2026 reviewed Enzyme
P09238 BXGT006875 Stromelysin-2 4319 reviewed Enzyme
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P13647 BXGT007937 Keratin, type II cytoskeletal 5 3852 reviewed
P14679 BXGT008039 Tyrosinase 7299 reviewed Enzyme
P14902 BXGT008065 Indoleamine 2,3-dioxygenase 1 3620 reviewed
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15941 BXGT008176 Mucin-1 4582 reviewed
P16050 BXGT008184 Arachidonate 15-lipoxygenase 246 reviewed Enzyme
P16234 BXGT008209 Platelet-derived growth factor receptor alpha 5156 reviewed Kinase
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P16455 BXGT008229 Methylated-DNA--protein-cysteine methyltransferase 4255 reviewed
P16581 BXGT008245 E-selectin 6401 reviewed
P20132 BXGT008546 L-serine dehydratase/L-threonine deaminase 10993 reviewed Enzyme
P21583 BXGT008667 Kit ligand 4254 reviewed
P21860 BXGT008698 Receptor tyrosine-protein kinase erbB-3 2065 reviewed Kinase
P22749 BXGT008803 Granulysin 10578 reviewed
P23470 BXGT008872 Receptor-type tyrosine-protein phosphatase gamma 5793 reviewed Enzyme
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P30086 BXGT009400 Phosphatidylethanolamine-binding protein 1 5037 reviewed Enzyme modulator
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P32119 BXGT009600 Peroxiredoxin-2 7001 reviewed Enzyme
P33991 BXGT009745 DNA replication licensing factor MCM4 4173 reviewed Enzyme
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P39900 BXGT010148 Macrophage metalloelastase 4321 reviewed Enzyme
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P43489 BXGT010394 Tumor necrosis factor receptor superfamily member 4 7293 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P48775 BXGT010662 Tryptophan 2,3-dioxygenase 6999 reviewed Enzyme
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
P51679 BXGT010877 C-C chemokine receptor type 4 1233 reviewed G-protein coupled receptor
P51692 BXGT010885 Signal transducer and activator of transcription 5B 6777 reviewed Nucleic acid binding
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P62258 BXGT011415 14-3-3 protein epsilon 7531 reviewed Chaperone
P78504 BXGT011844 Protein jagged-1 182 reviewed
Q00796 BXGT012549 Sorbitol dehydrogenase 6652 reviewed Enzyme
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q04721 BXGT012777 Neurogenic locus notch homolog protein 2 4853 reviewed
Q04912 BXGT012790 Macrophage-stimulating protein receptor 4486 reviewed Kinase
Q07812 BXGT012940 Apoptosis regulator BAX 581 reviewed Signaling
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 4170 reviewed Signaling
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q15063 BXGT013531 Periostin 10631 reviewed Signaling
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15257 BXGT013554 Serine/threonine-protein phosphatase 2A activator 5524 reviewed Enzyme modulator
Q15465 BXGT013573 Sonic hedgehog protein 6469 reviewed
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q6N021 BXGT016378 Methylcytosine dioxygenase TET2 54790 reviewed
Q86TM3 BXGT017607 Probable ATP-dependent RNA helicase DDX53 168400 reviewed
Q8TDS5 BXGT018813 Oxoeicosanoid receptor 1 165140 reviewed G-protein coupled receptor
Q8TDV0 BXGT018815 Probable G-protein coupled receptor 151 134391 reviewed G-protein coupled receptor
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9NYA1 BXGT021254 Sphingosine kinase 1 8877 reviewed Kinase
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9ULV1 BXGT021764 Frizzled-4 8322 reviewed G-protein coupled receptor
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UNW8 BXGT021793 Probable G-protein coupled receptor 132 29933 reviewed G-protein coupled receptor
Q9Y3B4 BXGT022255 Splicing factor 3B subunit 6 51639 reviewed
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
P16284 BXGT022972 Platelet endothelial cell adhesion molecule 5175 reviewed Cell adhesion
Q01543 BXGT023137 Friend leukemia integration 1 transcription factor 2313 reviewed Transcription factor
Q96QC4 BXGT023878 MHC class I polypeptide-related sequence A 100507436 unreviewed
P21926 BXGT024578 CD9 antigen 928 reviewed
Q9BYE2 BXGT024631 Transmembrane protease serine 13 84000 reviewed Enzyme
Q14566 BXGT025969 DNA replication licensing factor MCM6 4175 reviewed Enzyme
P33993 BXGT025970 DNA replication licensing factor MCM7 4176 reviewed Enzyme
P11836 BXGT025994 B-lymphocyte antigen CD20 931 reviewed Receptor
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease