Showing entry for Tumor necrosis factor receptor superfamily member 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010394
Protein NameTumor necrosis factor receptor superfamily member 4
Uniport IdP43489
GeneTNFRSF4
Gene Id7293
DomainTNFR_c6
Pfam PF00020  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006955 immune response
Biological Process GO:0006954 inflammatory response
Biological Process GO:0050710 negative regulation of cytokine secretion
Biological Process GO:0043433 negative regulation of DNA-binding transcription factor activity
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0030890 positive regulation of B cell proliferation
Biological Process GO:0051024 positive regulation of immunoglobulin secretion
Biological Process GO:0042098 T cell proliferation
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway
molecular function GO:0005031 tumor necrosis factor-activated receptor activity
molecular function GO:0001618 virus receptor activity
cellular component GO:0009986 cell surface
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5669034 TNFs bind their physiological receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007129 BXGD000439 Merkel cell carcinoma Neoplasms; Infections
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007273 BXGD000455 Carotid Artery Diseases Nervous System Diseases; Cardiovascular Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014060 BXGD000882 Encephalitis, St. Louis Infections; Nervous System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018889 BXGD001243 Helminthiasis Infections
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020097 BXGD001360 HTLV-I Infections Infections; Immune System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022577 BXGD001556 Keratoconjunctivitis, Vernal Eye Diseases; Immune System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023817 BXGD001706 Hyperlipoproteinemia Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026499 BXGD001905 Monosomy Pathological Conditions, Signs and Symptoms
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026896 BXGD001946 Myasthenia Gravis Neoplasms; Immune System Diseases; Nervous System Diseases
C0026948 BXGD001952 Mycosis Fungoides Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035235 BXGD002519 Respiratory Syncytial Virus Infections Infections
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0040100 BXGD002840 Thymoma Neoplasms; Hemic and Lymphatic Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0220597 BXGD004292 Adult Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220644 BXGD004306 Childhood Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0242584 BXGD005179 Autoimmune thrombocytopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0272286 BXGD006337 Thrombocytopenia due to platelet alloimmunization Hemic and Lymphatic Diseases
C0278689 BXGD006563 Recurrent ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0341106 BXGD007389 Eosinophilic esophagitis Digestive System Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0494261 BXGD009023 Combined immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0520736 BXGD009105 Coombs positive hemolytic anemia Hemic and Lymphatic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0740903 BXGD010015 allergic symptom
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C0948201 BXGD011515 Alloimmunisation
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1512508 BXGD013192 Human herpesvirus 8 infection Infections; Immune System Diseases
C1519680 BXGD013244 Tumor Immunity Pathological Conditions, Signs and Symptoms
C1719672 BXGD013659 Severe Sepsis Pathological Conditions, Signs and Symptoms; Infections
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363741 BXGD017100 HIV-1 infection
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C3160909 BXGD018497 Autoimmune arthritis
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3495801 BXGD019004 Granulomatosis with polyangiitis Respiratory Tract Diseases; Immune System Diseases; Cardiovascular Diseases
C3665419 BXGD019285 intracranial glioma Neoplasms; Nervous System Diseases
C3714514 BXGD019409 Infection Infections
C3810053 BXGD019633 IMMUNODEFICIENCY 16
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3875321 BXGD019874 Inflammatory dermatosis Skin and Connective Tissue Diseases
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4048329 BXGD021904 Immunosuppression
C4529962 BXGD023178 Fatty Liver Disease
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721779 BXGD023769 Ovarian cancer stage IV
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004275 Acetaldehyde 44.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein