adisease

Showing entry for Myelofibrosis

General Disease Information
BXGD Id	BXGD001957
Disease Name	Myelofibrosis
Disease CUI Id	C0026987
MeSH Codes	C23 C04 C15
Disease Class Name	Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id	HP:0001871
Human Phenotype Ontology Term	Abnormality of blood and blood-forming tissues
Disease Ontology Id	DOID:7 DOID:14566
Disease Ontology Class Name	disease of anatomical entity; disease of cellular proliferation
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14965	BXGT004117	Aurora kinase A	6790	reviewed	Kinase
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O75874	BXGT005157	Isocitrate dehydrogenase [NADP] cytoplasmic	3417	reviewed
P00519	BXGT005570	Tyrosine-protein kinase ABL1	25	reviewed	Kinase
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04792	BXGT006264	Heat shock protein beta-1	3315	reviewed
P05187	BXGT006339	Alkaline phosphatase, placental type	250	reviewed	Enzyme
P07202	BXGT006565	Thyroid peroxidase	7173	reviewed	Enzyme
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P08151	BXGT006731	Zinc finger protein GLI1	2735	reviewed
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08842	BXGT006830	Steryl-sulfatase	412	reviewed	Enzyme
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09486	BXGT006897	SPARC	6678	reviewed	Signaling
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P09923	BXGT006942	Intestinal-type alkaline phosphatase	248	reviewed	Enzyme
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P10826	BXGT007622	Retinoic acid receptor beta	5915	reviewed	Nuclear receptor
P10997	BXGT007643	Islet amyloid polypeptide	3375	reviewed	Signaling
P11274	BXGT007681	Breakpoint cluster region protein	613	reviewed	Enzyme modulator
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P15428	BXGT008121	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	3248	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16109	BXGT008194	P-selectin	6403	reviewed
P16234	BXGT008209	Platelet-derived growth factor receptor alpha	5156	reviewed	Kinase
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P22004	BXGT008718	Bone morphogenetic protein 6	654	reviewed	Signaling
P22894	BXGT008815	Neutrophil collagenase	4317	reviewed	Enzyme
P23458	BXGT008868	Tyrosine-protein kinase JAK1	3716	reviewed	Kinase
P24941	BXGT009002	Cyclin-dependent kinase 2	1017	reviewed	Kinase
P25025	BXGT009006	C-X-C chemokine receptor type 2	3579	reviewed	G-protein coupled receptor
P27797	BXGT009206	Calreticulin	811	reviewed	Calcium-binding protein
P28300	BXGT009243	Protein-lysine 6-oxidase	4015	reviewed
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35442	BXGT009832	Thrombospondin-2	7058	reviewed
P35610	BXGT009855	Sterol O-acyltransferase 1	6646	reviewed	Enzyme
P36222	BXGT009914	Chitinase-3-like protein 1	1116	reviewed
P36888	BXGT009938	Receptor-type tyrosine-protein kinase FLT3	2322	reviewed	Kinase
P36897	BXGT009941	TGF-beta receptor type-1	7046	reviewed	Kinase
P40225	BXGT010168	Thrombopoietin	7066	reviewed
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41212	BXGT010235	Transcription factor ETV6	2120	reviewed	Transcription factor
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49916	BXGT010764	DNA ligase 3	3980	reviewed	Enzyme
P51617	BXGT010868	Interleukin-1 receptor-associated kinase 1	3654	reviewed	Kinase
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P53350	BXGT010984	Serine/threonine-protein kinase PLK1	5347	reviewed	Kinase
P53355	BXGT010985	Death-associated protein kinase 1	1612	reviewed	Kinase
P54136	BXGT011033	Arginine--tRNA ligase, cytoplasmic	5917	reviewed
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P98170	BXGT012231	E3 ubiquitin-protein ligase XIAP	331	reviewed	Enzyme modulator
Q01196	BXGT012575	Runt-related transcription factor 1	861	reviewed	Transcription factor
Q08722	BXGT013002	Leukocyte surface antigen CD47	961	reviewed
Q13231	BXGT013329	Chitotriosidase-1	1118	reviewed
Q13478	BXGT013362	Interleukin-18 receptor 1	8809	reviewed	Receptor
Q14332	BXGT013462	Frizzled-2	2535	reviewed	G-protein coupled receptor
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q59FK2	BXGT015276	Selenocysteine lyase variant	51540	unreviewed
Q6N021	BXGT016378	Methylcytosine dioxygenase TET2	54790	reviewed
Q8TCG1	BXGT018797	Protein CIP2A	57650	reviewed
Q92959	BXGT019400	Solute carrier organic anion transporter family member 2A1	6578	reviewed	Transporter
Q96I15	BXGT019674	Selenocysteine lyase	51540	reviewed	Enzyme
Q9UHD2	BXGT021697	Serine/threonine-protein kinase TBK1	29110	reviewed	Kinase
Q9Y618	BXGT022315	Nuclear receptor corepressor 2	9612	reviewed	Transcription factor
Q9Y6K1	BXGT022331	DNA (cytosine-5)-methyltransferase 3A	1788	reviewed
P00738	BXGT022874	Haptoglobin	3240	reviewed	Enzyme
P62263	BXGT026033	40S ribosomal protein S14	6208	reviewed	Nucleic acid binding

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}