Showing entry for Islet amyloid polypeptide


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007643
Protein NameIslet amyloid polypeptide
Uniport IdP10997
GeneIAPP
Gene Id3375
DomainCalc_CGRP_IAPP
Pfam PF00214  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04950 Maturity onset diabetes of the young
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0097647 amylin receptor signaling pathway
Biological Process GO:1990000 amyloid fibril formation
Biological Process GO:0006915 apoptotic process
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0042755 eating behavior
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:1905907 negative regulation of amyloid fibril formation
Biological Process GO:0045779 negative regulation of bone resorption
Biological Process GO:0045596 negative regulation of cell differentiation
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0010823 negative regulation of mitochondrion organization
Biological Process GO:0031333 negative regulation of protein-containing complex assembly
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:1905665 positive regulation of calcium ion import across plasma membrane
Biological Process GO:0010942 positive regulation of cell death
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0010739 positive regulation of protein kinase A signaling
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:0031648 protein destabilization
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0019233 sensory perception of pain
Biological Process GO:0007165 signal transduction
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0005179 hormone activity
molecular function GO:0042802 identical protein binding
molecular function GO:0005102 signaling receptor binding
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0016234 inclusion body
cellular component GO:0043025 neuronal cell body
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-186712 Regulation of beta-cell development
R-HSA-210745 Regulation of gene expression in beta cells
R-HSA-372790 Signaling by GPCR
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-392499 Metabolism of proteins
R-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors
R-HSA-500792 GPCR ligand binding
R-HSA-5663205 Infectious disease
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664433 Leishmania parasite growth and survival
R-HSA-977225 Amyloid fiber formation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0001815 BXGD000078 Primary Myelofibrosis Hemic and Lymphatic Diseases
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0002152 BXGD000104 Alloxan Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011269 BXGD000710 Dementia, Vascular Nervous System Diseases; Mental Disorders; Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011875 BXGD000757 Diabetic Angiopathies Endocrine System Diseases; Cardiovascular Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014553 BXGD000931 Absence Epilepsy Nervous System Diseases
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017689 BXGD001148 Glucagonoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0020175 BXGD001362 Hunger Behavior and Behavior Mechanisms
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020479 BXGD001399 Hyperlipoproteinemia Type III Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0022336 BXGD001535 Creutzfeldt-Jakob disease Infections; Nervous System Diseases; Mental Disorders
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025267 BXGD001845 Multiple Endocrine Neoplasia Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0026987 BXGD001957 Myelofibrosis Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029401 BXGD002135 Osteitis Deformans Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030286 BXGD002201 Pancreatic Diseases Digestive System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032320 BXGD002350 Pneumoperitoneum Digestive System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0035585 BXGD002561 Rickettsia Infections Infections
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038358 BXGD002748 Gastric ulcer Digestive System Diseases
C0038433 BXGD002754 Streptozotocin Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040128 BXGD002844 Thyroid Diseases Endocrine System Diseases
C0040137 BXGD002846 Thyroid Nodule Neoplasms; Endocrine System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0153633 BXGD003674 Malignant neoplasm of brain Neoplasms; Nervous System Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0158252 BXGD003877 Intervertebral disc disorder Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0158266 BXGD003878 Intervertebral Disc Degeneration Musculoskeletal Diseases
C0162534 BXGD003953 Prion Diseases Infections; Nervous System Diseases
C0162830 BXGD003987 Dermatitis, Phototoxic Skin and Connective Tissue Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205734 BXGD004115 Diabetes, Autoimmune Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0221014 BXGD004364 Reactive systemic amyloidosis Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0232197 BXGD004536 Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234119 BXGD004622 Neuromuscular inhibition
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0265344 BXGD005527 Donohue Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Endocrine System Diseases
C0268407 BXGD005936 Senile cardiac amyloidosis Nutritional and Metabolic Diseases; Cardiovascular Diseases
C0270549 BXGD006079 Generalized Anxiety Disorder Mental Disorders
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278519 BXGD006531 Recurrent Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0282577 BXGD006816 Congenital Disorders of Glycosylation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0341862 BXGD007426 Hypothalamic amenorrhea Nervous System Diseases; Endocrine System Diseases
C0342276 BXGD007449 Maturity onset diabetes mellitus in young Nutritional and Metabolic Diseases; Endocrine System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0362046 BXGD007959 Prediabetes syndrome Nutritional and Metabolic Diseases; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0393735 BXGD008132 Headache Disorders Nervous System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0600260 BXGD009701 Lung Diseases, Obstructive Respiratory Tract Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0848332 BXGD010879 Spots on skin Skin and Connective Tissue Diseases
C0853897 BXGD010985 Diabetic Cardiomyopathies Endocrine System Diseases; Cardiovascular Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0856874 BXGD011123 Subclinical diabetes
C0948379 BXGD011533 Impaired insulin secretion
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1561826 BXGD013364 Overweight and obesity
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1845076 BXGD014708 Lymphoproliferative Syndrome, X-Linked, 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2242710 BXGD016997 Intra-Abdominal Hypertension Musculoskeletal Diseases; Cardiovascular Diseases
C2609129 BXGD017167 Autoimmune pancreatitis Digestive System Diseases; Immune System Diseases
C2718001 BXGD017521 Protein Misfolding Disorders Nutritional and Metabolic Diseases
C2751492 BXGD017718 AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATED Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2931038 BXGD017944 Pancreatic carcinoma, familial Digestive System Diseases; Neoplasms; Endocrine System Diseases
C2931689 BXGD018049 Dystrophia myotonica 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2936349 BXGD018109 Plaque, Amyloid Pathological Conditions, Signs and Symptoms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2985280 BXGD018223 Blood Protein Measurement
C2987145 BXGD018247 Pancreatic Intraepithelial Neoplasia-3
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3534591 BXGD019064 Diabetic Heart Disease Nutritional and Metabolic Diseases; Endocrine System Diseases
C3536715 BXGD019070 AA amyloidosis Nutritional and Metabolic Diseases
C3554225 BXGD019205 LEPTIN RECEPTOR DEFICIENCY
C3714948 BXGD019440 PACHYONYCHIA CONGENITA 3
C3805278 BXGD019474 Extrahepatic Cholangiocarcinoma Neoplasms
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002616 Copper 63.55
BXGC0003705 Chloride 35.45
BXGC0013582 Curcumin 368.13
BXGC0023042 Genistein 8-C-glucoside 432.11
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein