adisease

Showing entry for Somatic mutation

General Disease Information
BXGD Id	BXGD009319
Disease Name	Somatic mutation
Disease CUI Id	C0544886
MeSH Codes
Disease Class Name
Semantic Type	Cell or Molecular Dysfunction
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O15169	BXGT004134	Axin-1	8312	reviewed
O15297	BXGT004149	Protein phosphatase 1D	8493	reviewed	Enzyme
O43683	BXGT004614	Mitotic checkpoint serine/threonine-protein kinase BUB1	699	reviewed	Kinase
O60260	BXGT004864	E3 ubiquitin-protein ligase parkin	5071	reviewed	Enzyme
O60566	BXGT004884	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	701	reviewed	Kinase
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O75874	BXGT005157	Isocitrate dehydrogenase [NADP] cytoplasmic	3417	reviewed
O96017	BXGT005415	Serine/threonine-protein kinase Chk2	11200	reviewed	Kinase
P00519	BXGT005570	Tyrosine-protein kinase ABL1	25	reviewed	Kinase
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P06748	BXGT006497	Nucleophosmin	4869	reviewed	Chaperone
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10276	BXGT007553	Retinoic acid receptor alpha	5914	reviewed	Nuclear receptor
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P11274	BXGT007681	Breakpoint cluster region protein	613	reviewed	Enzyme modulator
P11509	BXGT007716	Cytochrome P450 2A6	1548	reviewed
P11717	BXGT007740	Cation-independent mannose-6-phosphate receptor	3482	reviewed	Receptor
P12830	BXGT007852	Cadherin-1	999	reviewed
P12931	BXGT007859	Proto-oncogene tyrosine-protein kinase Src	6714	reviewed	Kinase
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P16083	BXGT008187	Ribosyldihydronicotinamide dehydrogenase [quinone]	4835	reviewed
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	1385	reviewed
P16234	BXGT008209	Platelet-derived growth factor receptor alpha	5156	reviewed	Kinase
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P21359	BXGT008640	Neurofibromin	4763	reviewed	Enzyme modulator
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P22681	BXGT008795	E3 ubiquitin-protein ligase CBL	867	reviewed	Enzyme
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P27797	BXGT009206	Calreticulin	811	reviewed	Calcium-binding protein
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35658	BXGT009859	Nuclear pore complex protein Nup214	8021	reviewed	Nucleic acid binding
P36888	BXGT009938	Receptor-type tyrosine-protein kinase FLT3	2322	reviewed	Kinase
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P40225	BXGT010168	Thrombopoietin	7066	reviewed
P41212	BXGT010235	Transcription factor ETV6	2120	reviewed	Transcription factor
P41279	BXGT010254	Mitogen-activated protein kinase kinase kinase 8	1326	reviewed	Kinase
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P48023	BXGT010604	Tumor necrosis factor ligand superfamily member 6	356	reviewed	Signaling
P49917	BXGT010765	DNA ligase 4	3981	reviewed
P52701	BXGT010943	DNA mismatch repair protein Msh6	2956	reviewed	Nucleic acid binding
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
Q01196	BXGT012575	Runt-related transcription factor 1	861	reviewed	Transcription factor
Q03468	BXGT012716	DNA excision repair protein ERCC-6	2074	reviewed
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q09472	BXGT013038	Histone acetyltransferase p300	2033	reviewed
Q12778	BXGT013263	Forkhead box protein O1	2308	reviewed
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13951	BXGT013407	Core-binding factor subunit beta	865	reviewed
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q14982	BXGT013518	Opioid-binding protein/cell adhesion molecule	4978	reviewed
Q15831	BXGT013604	Serine/threonine-protein kinase STK11	6794	reviewed	Kinase
Q6N021	BXGT016378	Methylcytosine dioxygenase TET2	54790	reviewed
Q86YC2	BXGT017633	Partner and localizer of BRCA2	79728	reviewed
Q8TD19	BXGT018804	Serine/threonine-protein kinase Nek9	91754	reviewed	Kinase
Q92698	BXGT019362	DNA repair and recombination protein RAD54-like	8438	reviewed
Q99728	BXGT019956	BRCA1-associated RING domain protein 1	580	reviewed
Q9UIF7	BXGT021717	Adenine DNA glycosylase	4595	reviewed	Enzyme
Q9Y6K1	BXGT022331	DNA (cytosine-5)-methyltransferase 3A	1788	reviewed
P35232	BXGT022663	Prohibitin	5245	reviewed
P43146	BXGT022852	Netrin receptor DCC	1630	reviewed
P35240	BXGT022927	Merlin	4771	reviewed
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
Q59FF6	BXGT023693	Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant	2074	unreviewed
Q96L73	BXGT024676	Histone-lysine N-methyltransferase, H3 lysine-36 specific	64324	reviewed	Epigenetic regulator
Q14980	BXGT025336	Nuclear mitotic apparatus protein 1	4926	reviewed
P62263	BXGT026033	40S ribosomal protein S14	6208	reviewed	Nucleic acid binding
P19532	BXGT026110	Transcription factor E3	7030	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}