Showing entry for Nuclear mitotic apparatus protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025336
Protein NameNuclear mitotic apparatus protein 1
Uniport IdQ14980
GeneNUMA1
Gene Id4926
Domain-
Pfam -  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0055048 anastral spindle assembly
Biological Process GO:0030953 astral microtubule organization
Biological Process GO:0051301 cell division
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0000132 establishment of mitotic spindle orientation
Biological Process GO:0090161 Golgi ribbon formation
Biological Process GO:0034499 late endosome to Golgi transport
Biological Process GO:0051321 meiotic cell cycle
Biological Process GO:0001578 microtubule bundle formation
Biological Process GO:0031023 microtubule organizing center organization
Biological Process GO:0006997 nucleus organization
Biological Process GO:0030513 positive regulation of BMP signaling pathway
Biological Process GO:0051984 positive regulation of chromosome segregation
Biological Process GO:1905820 positive regulation of chromosome separation
Biological Process GO:0051798 positive regulation of hair follicle development
Biological Process GO:0032388 positive regulation of intracellular transport
Biological Process GO:0045618 positive regulation of keratinocyte differentiation
Biological Process GO:0031116 positive regulation of microtubule polymerization
Biological Process GO:1902846 positive regulation of mitotic spindle elongation
Biological Process GO:1904778 positive regulation of protein localization to cell cortex
Biological Process GO:1902365 positive regulation of protein localization to spindle pole body
Biological Process GO:1905832 positive regulation of spindle assembly
Biological Process GO:0034067 protein localization to Golgi apparatus
Biological Process GO:0006622 protein targeting to lysosome
Biological Process GO:0071955 recycling endosome to Golgi transport
Biological Process GO:0090235 regulation of metaphase plate congression
Biological Process GO:0060236 regulation of mitotic spindle organization
Biological Process GO:0070861 regulation of protein exit from endoplasmic reticulum
molecular function GO:0097718 disordered domain specific binding
molecular function GO:0070840 dynein complex binding
molecular function GO:0008017 microtubule binding
molecular function GO:0051011 microtubule minus-end binding
molecular function GO:0051010 microtubule plus-end binding
molecular function GO:0035091 phosphatidylinositol binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0005198 structural molecule activity
molecular function GO:0015631 tubulin binding
cellular component GO:0005938 cell cortex
cellular component GO:0099738 cell cortex region
cellular component GO:0005813 centrosome
cellular component GO:0005694 chromosome
cellular component GO:0055028 cortical microtubule
cellular component GO:1905720 cytoplasmic microtubule bundle
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0070062 extracellular exosome
cellular component GO:0019897 extrinsic component of plasma membrane
cellular component GO:0005794 Golgi apparatus
cellular component GO:0000139 Golgi membrane
cellular component GO:0097575 lateral cell cortex
cellular component GO:0016328 lateral plasma membrane
cellular component GO:0097427 microtubule bundle
cellular component GO:0036449 microtubule minus-end
cellular component GO:0035371 microtubule plus-end
cellular component GO:0072686 mitotic spindle
cellular component GO:0061673 mitotic spindle astral microtubule
cellular component GO:1990023 mitotic spindle midzone
cellular component GO:0097431 mitotic spindle pole
cellular component GO:0043025 neuronal cell body
cellular component GO:0016363 nuclear matrix
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
cellular component GO:0005819 spindle
cellular component GO:0005876 spindle microtubule
cellular component GO:0000922 spindle pole
cellular component GO:0031616 spindle pole centrosome
Reactome
Pathway Id Pathway Name
R-HSA-1640170 Cell Cycle
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-68875 Mitotic Prophase
R-HSA-68877 Mitotic Prometaphase
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle, Mitotic
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012739 BXGD000786 Disseminated Intravascular Coagulation Hemic and Lymphatic Diseases
C0013491 BXGD000847 Ecchymosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0014457 BXGD000915 Eosinophilia Hemic and Lymphatic Diseases
C0014591 BXGD000938 Epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017086 BXGD001091 Gangrene Pathological Conditions, Signs and Symptoms
C0017565 BXGD001118 Gingival Hemorrhage Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0018965 BXGD001258 Hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023518 BXGD001677 Leukocytosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0025874 BXGD001880 Metrorrhagia Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0038362 BXGD002749 Stomatitis Stomatognathic Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151825 BXGD003481 Bone pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0162820 BXGD003985 Dermatitis, Allergic Contact Skin and Connective Tissue Diseases; Immune System Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0202236 BXGD004086 Triglycerides measurement
C0206644 BXGD004209 Histiocytoma, Benign Fibrous Neoplasms
C0206694 BXGD004245 Mucoepidermoid Carcinoma Neoplasms
C0231807 BXGD004524 Dyspnea on exertion Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0239134 BXGD004964 Productive Cough Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0241144 BXGD005080 Petechiae of skin Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0376480 BXGD007998 Gingival Overgrowth Stomatognathic Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0431375 BXGD008677 Classical Lissencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0544886 BXGD009319 Somatic mutation
C0553681 BXGD009406 Hypofibrinogenemia
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1292778 BXGD012237 Chronic myeloproliferative disorder Neoplasms; Hemic and Lymphatic Diseases
C1301194 BXGD012284 Salivary duct carcinoma Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306759 BXGD012374 Eosinophilic disorder Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1860320 BXGD015977 Bone marrow hypercellularity
C1963077 BXGD016680 Bone Pain, CTCAE 3.0
C2076600 BXGD016912 Influenza due to Influenza A virus subtype H1N1 Infections; Respiratory Tract Diseases
C2145472 BXGD016931 Urothelial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2939461 BXGD018180 Myeloid neoplasm Neoplasms; Hemic and Lymphatic Diseases
C4022608 BXGD020936 Oral cavity bleeding
C4023031 BXGD021076 Abnormal granulocytopoietic cell morphology
C4316812 BXGD022704 Fibrinogen Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C4476767 BXGD022864 Diffuse alveolar hemorrhage
C4552938 BXGD023529 Productive Cough, CTCAE
C4554063 BXGD023559 Bone Pain, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein