Showing entry for Transcription factor E3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT026110
Protein NameTranscription factor E3
Uniport IdP19532
GeneTFE3
Gene Id7030
DomainDUF3371; HLH; MITF_TFEB_C_3_N
Pfam PF11851   PF00010   PF15951  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04137 Mitophagy - animal
6. Human Diseases 6.1 Cancers: Overview hsa05202 Transcriptional misregulation in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05211 Renal cell carcinoma
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0006959 humoral immune response
Biological Process GO:0120163 negative regulation of cold-induced thermogenesis
Biological Process GO:0090336 positive regulation of brown fat cell differentiation
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045670 regulation of osteoclast differentiation
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0046983 protein dimerization activity
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:1990837 sequence-specific double-stranded DNA binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003615 BXGD000212 Appendicitis Digestive System Diseases; Infections
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0018923 BXGD001248 Hemangiosarcoma Neoplasms
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0022665 BXGD001573 Kidney Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0026277 BXGD001899 Mixed Salivary Gland Tumor Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027668 BXGD002019 Neoplasms, Vascular Tissue Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0037579 BXGD002694 Soft Tissue Neoplasms Neoplasms
C0043194 BXGD003036 Wiskott-Aldrich Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0079218 BXGD003066 Fibromatosis, Aggressive Neoplasms
C0085167 BXGD003137 Granular cell tumor Neoplasms
C0085693 BXGD003241 Acute appendicitis NOS (disorder) Digestive System Diseases; Infections
C0205824 BXGD004128 Liposarcoma, Dedifferentiated Neoplasms
C0206628 BXGD004193 Mesoblastic Nephroma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0206647 BXGD004212 Dermatofibrosarcoma Neoplasms
C0206651 BXGD004215 Clear Cell Sarcoma of Soft Tissue Neoplasms
C0206657 BXGD004220 Alveolar Soft Part Sarcoma Neoplasms
C0206685 BXGD004240 Acinar Cell Carcinoma Neoplasms
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0206724 BXGD004269 Sex Cord-Stromal Tumor Neoplasms
C0206732 BXGD004277 Epithelioid hemangioendothelioma Neoplasms
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220613 BXGD004297 Adult Soft Tissue Sarcoma
C0220645 BXGD004307 Childhood Soft Tissue Sarcoma
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242363 BXGD005156 Islet Cell Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0266305 BXGD005648 Fused Kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0278592 BXGD006544 Adult Angiosarcoma Neoplasms
C0278678 BXGD006556 Metastatic Renal Cell Cancer
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0279544 BXGD006631 Adult Alveolar Soft Part Sarcoma Neoplasms
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0279985 BXGD006704 Childhood Alveolar Soft Part Sarcoma Neoplasms
C0279988 BXGD006707 Childhood Angiosarcoma Neoplasms
C0282607 BXGD006818 Vascular Neoplasms Neoplasms; Cardiovascular Diseases
C0333516 BXGD006957 Tumor necrosis Pathological Conditions, Signs and Symptoms
C0334121 BXGD006996 Inflammatory Myofibroblastic Tumor Pathological Conditions, Signs and Symptoms
C0334331 BXGD007032 Juxtaglomerular tumor Neoplasms; Endocrine System Diseases
C0334459 BXGD007074 Infantile fibrosarcoma Neoplasms
C0334538 BXGD007106 Epithelioid hemangioendothelioma, malignant Neoplasms
C0334607 BXGD007135 Psammomatous Meningioma Neoplasms; Nervous System Diseases
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0392784 BXGD008069 Dermatofibrosarcoma Protuberans Neoplasms
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0544886 BXGD009319 Somatic mutation
C0546483 BXGD009341 Lung cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Respiratory Tract Diseases
C0549523 BXGD009386 Oropharynx (excludes nasopharynx)
C0559460 BXGD009469 Adrenal neuroblastoma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598790 BXGD009671 lung sarcoma Neoplasms; Respiratory Tract Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0878681 BXGD011387 Dent's disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0949541 BXGD011578 Hurthle Cell Tumor Neoplasms
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1261473 BXGD011855 Sarcoma Neoplasms
C1266042 BXGD011938 Chromophobe Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266043 BXGD011939 Sarcomatoid Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266044 BXGD011940 Collecting Duct Carcinoma of the Kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266127 BXGD011968 Histiocytoma, Angiomatoid Fibrous Neoplasms
C1266128 BXGD011969 Ossifying fibromyxoid tumor Neoplasms
C1300127 BXGD012268 Perivascular Epithelioid Cell Neoplasms Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306837 BXGD012377 Papillary Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1328479 BXGD012467 Pancreatic Endocrine Carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1332965 BXGD012565 Congenital Mesoblastic Nephroma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1333001 BXGD012578 Childhood Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1333065 BXGD012588 Lung Clear Cell Tumor
C1334699 BXGD012731 Mesenchymal Cell Neoplasm Neoplasms
C1337011 BXGD012874 Well Differentiated Pancreatic Endocrine Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1337036 BXGD012879 Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions
C1368683 BXGD012900 Epithelioma Neoplasms
C1368821 BXGD012903 Ovarian Sclerosing Stromal Tumor
C1378050 BXGD012931 Oncocytic Neoplasm
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1402291 BXGD013015 Pigmented lesions
C1510502 BXGD013175 Oxyphilic Adenoma Neoplasms
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2064402 BXGD016908 Liver Epithelioid Hemangioendothelioma Neoplasms
C2826323 BXGD017790 Refractory Cytopenia of Childhood
C2931852 BXGD018079 Clear-cell metastatic renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3693482 BXGD019337 Giant Cell Fibroblastoma Neoplasms
C3839062 BXGD019769 Perivascular epithelioid tumor, malignant Neoplasms
C3898127 BXGD020061 Non-Metastatic Childhood Soft Tissue Sarcoma
C3899665 BXGD020096 Childhood Epithelioid Hemangioendothelioma Neoplasms
C3900104 BXGD020110 Adult Epithelioid Hemangioendothelioma Neoplasms
C4048329 BXGD021904 Immunosuppression
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4518194 BXGD023014 Epithelioid angiomyolipoma Neoplasms
C4518356 BXGD023020 MiT family translocation renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4518375 BXGD023021 Mucinous tubular and spindle cell carcinoma
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4551687 BXGD023392 Sarcoma of soft tissue Neoplasms
C4721698 BXGD023763 Metastatic Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006635 Luteolin 286.24
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein