Showing entry for Ribosyldihydronicotinamide dehydrogenase [quinone]


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008187
Protein NameRibosyldihydronicotinamide dehydrogenase [quinone]
Uniport IdP16083
GeneNQO2
Gene Id4835
DomainFlavodoxin_2
Pfam PF02525  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007613 memory
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:2000379 positive regulation of reactive oxygen species metabolic process
Biological Process GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
Biological Process GO:0006805 xenobiotic metabolic process
molecular function GO:0031404 chloride ion binding
molecular function GO:0001512 dihydronicotinamide riboside quinone reductase activity
molecular function GO:0009055 electron transfer activity
molecular function GO:0071949 FAD binding
molecular function GO:1904408 melatonin binding
molecular function GO:0003955 NAD(P)H dehydrogenase (quinone) activity
molecular function GO:0016491 oxidoreductase activity
molecular function GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors
molecular function GO:0042803 protein homodimerization activity
molecular function GO:1905594 resveratrol binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-211859 Biological oxidations
R-HSA-211945 Phase I - Functionalization of compounds
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001824 BXGD000081 Agranulocytosis Hemic and Lymphatic Diseases
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002622 BXGD000119 Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005956 BXGD000356 Bone Marrow Diseases Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011616 BXGD000739 Contact Dermatitis Skin and Connective Tissue Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024530 BXGD001783 Malaria Infections
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025261 BXGD001843 Memory Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0162351 BXGD003938 Contact hypersensitivity Skin and Connective Tissue Diseases
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236663 BXGD004817 Alcohol withdrawal syndrome Chemically-Induced Disorders; Mental Disorders
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279628 BXGD006659 Adenocarcinoma Of Esophagus Digestive System Diseases; Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0544886 BXGD009319 Somatic mutation
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751292 BXGD010380 Age-Related Memory Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751293 BXGD010381 Memory Disorder, Semantic Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751294 BXGD010382 Memory Disorder, Spatial Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751295 BXGD010383 Memory Loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1709457 BXGD013625 Papillary Thyroid Microcarcinoma Neoplasms; Endocrine System Diseases
C2936380 BXGD018112 Neointima Pathological Conditions, Signs and Symptoms
C2985280 BXGD018223 Blood Protein Measurement
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0001767 (E)-Resveratrol 228.25
BXGC0002916 Melatonin 232.28
BXGC0003705 Chloride 35.45
BXGC0005344 Casimiroin 233.22
BXGC0005683 Quercetin 302.24
BXGC0005867 Serotonin 176.22
BXGC0005871 Dopamine 153.18
BXGC0015681 (E)-3,4,3',5'-Tetramethoxystilbene 300.14
BXGC0019582 1-Methoxyphenazine 210.08
BXGC0023497 Pterostilbene 256.11
BXGC0026591 1,3-Naphthalenediol 160.05
BXGC0034473 2,3-Dimethoxyphenazine 240.09
BXGC0034783 Doxorubicin 543.17
BXGC0038197 2-Methoxyphenazine 210.08
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0043766 Kaempferol-3-O-Rhamnoside 432.11
BXGC0044200 Menadione 172.05
BXGC0045808 Sid470675 286.12
BXGC0046518 Chloroquine 319.18
BXGC0047692 Gefitinib 446.15
BXGC0051357 Trismethoxyresveratrol 270.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein