Showing entry for Metabotropic glutamate receptor 6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004150
Protein NameMetabotropic glutamate receptor 6
Uniport IdO15303
GeneGRM6
Gene Id2916
Domain7tm_3; ANF_receptor; NCD3G
Pfam PF00003   PF01094   PF07562  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0050908 detection of light stimulus involved in visual perception
Biological Process GO:0009584 detection of visible light
Biological Process GO:0007216 G protein-coupled glutamate receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0090280 positive regulation of calcium ion import
Biological Process GO:0051966 regulation of synaptic transmission, glutamatergic
Biological Process GO:0060041 retina development in camera-type eye
molecular function GO:0008066 glutamate receptor activity
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0001642 group III metabotropic glutamate receptor activity
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0030425 dendrite
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0000139 Golgi membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0035841 new growing cell tip
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-500792 GPCR ligand binding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0018975 BXGD001259 Hemeralopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0034951 BXGD002498 Refractive Errors Eye Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0271093 BXGD006162 Stargardt's disease
C0271183 BXGD006169 Severe myopia Eye Diseases
C0339527 BXGD007260 Leber Congenital Amaurosis Eye Diseases
C0339535 BXGD007263 Night blindness, congenital stationary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0524662 BXGD009238 Opiate Addiction Chemically-Induced Disorders; Mental Disorders
C1298695 BXGD012251 Hypoplasia of optic disc Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1848172 BXGD014908 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1850362 BXGD015134 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1864877 BXGD016267 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C3495587 BXGD018996 Night Blindness, Congenital Stationary, Type 1A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3501847 BXGD019030 Night blindness, congenital stationary, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3711543 BXGD019396 X-Linked Csnb Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4024756 BXGD021405 Abnormality of macular pigmentation
C4041558 BXGD021877 Cone-rod synaptic disorder, congenital nonprogressive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4048798 BXGD021909 Complete congenital stationary night blindness
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006162 L-Glutamic acid 147.13
BXGC0006186 L-Aspartic acid 133.1
BXGC0006187 2-Aminoheptanedioic acid 175.18
BXGC0023948 (S)-2-Aminoadipic Acid 161.07
BXGC0036441 Quisqualate 189.04
BXGC0036476 D-Glutamate 147.05
BXGC0038154 D-Aspartate 133.04
BXGC0049516 Kainic Acid 213.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein