Showing entry for Plexin-B1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004572
Protein NamePlexin-B1
Uniport IdO43157
GenePLXNB1
Gene Id5364
DomainPlexin_cytopl; PSI; Sema; TIG; TIG_2; TIG_plexin
Pfam PF08337   PF01437   PF01403   PF01833   PF18020   PF17960  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0016477 cell migration
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:1904862 inhibitory synapse assembly
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0007162 negative regulation of cell adhesion
Biological Process GO:0033689 negative regulation of osteoblast proliferation
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0043931 ossification involved in bone maturation
Biological Process GO:0050772 positive regulation of axonogenesis
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0051493 regulation of cytoskeleton organization
Biological Process GO:0043087 regulation of GTPase activity
Biological Process GO:0071526 semaphorin-plexin signaling pathway
Biological Process GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance
Biological Process GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
Biological Process GO:0007165 signal transduction
molecular function GO:0032794 GTPase activating protein binding
molecular function GO:0005096 GTPase activator activity
molecular function GO:0017154 semaphorin receptor activity
molecular function GO:0030215 semaphorin receptor binding
molecular function GO:0038023 signaling receptor activity
molecular function GO:0004888 transmembrane signaling receptor activity
cellular component GO:0005576 extracellular region
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0002116 semaphorin receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-373755 Semaphorin interactions
R-HSA-388396 GPCR downstream signalling
R-HSA-400685 Sema4D in semaphorin signaling
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-422475 Axon guidance
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013264 BXGD000808 Muscular Dystrophy, Duchenne Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024232 BXGD001751 Lymphatic Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0085543 BXGD003181 Epilepsia Partialis Continua Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0263361 BXGD005292 Psoriasis vulgaris Skin and Connective Tissue Diseases
C0270853 BXGD006119 Juvenile Myoclonic Epilepsy Nervous System Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0280324 BXGD006740 Laryngeal Squamous Cell Carcinoma Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0332853 BXGD006901 Anastomosis
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0343055 BXGD007593 Generalized pustular psoriasis Skin and Connective Tissue Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0747845 BXGD010184 early pregnancy
C0917713 BXGD011404 Becker Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1292753 BXGD012226 Primary Effusion Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1516061 BXGD013211 Astler-Coller B1 Rectal Carcinoma
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0018397 beta-1,4-mannan 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein