Showing entry for Coagulation factor XII


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005640
Protein NameCoagulation factor XII
Uniport IdP00748
GeneF12
Gene Id2161
DomainEGF; fn1; fn2; Kringle; Trypsin
Pfam PF00008   PF00039   PF00040   PF00051   PF00089  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007596 blood coagulation
Biological Process GO:0007597 blood coagulation, intrinsic pathway
Biological Process GO:0002542 Factor XII activation
Biological Process GO:0042730 fibrinolysis
Biological Process GO:0045087 innate immune response
Biological Process GO:0002353 plasma kallikrein-kinin cascade
Biological Process GO:0030194 positive regulation of blood coagulation
Biological Process GO:0051919 positive regulation of fibrinolysis
Biological Process GO:0010756 positive regulation of plasminogen activation
Biological Process GO:0016540 protein autoprocessing
Biological Process GO:0016485 protein processing
Biological Process GO:0006508 proteolysis
Biological Process GO:0051788 response to misfolded protein
Biological Process GO:0031638 zymogen activation
molecular function GO:0005509 calcium ion binding
molecular function GO:0051787 misfolded protein binding
molecular function GO:0004252 serine-type endopeptidase activity
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005886 plasma membrane
cellular component GO:0005791 rough endoplasmic reticulum
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade)
R-HSA-1643685 Disease
R-HSA-9651496 Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
R-HSA-9657688 Defective factor XII causes hereditary angioedema
R-HSA-9657689 Defective SERPING1 causes hereditary angioedema
R-HSA-9671793 Diseases of hemostasis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001622 BXGD000065 Adrenal Gland Hyperfunction Endocrine System Diseases
C0001883 BXGD000086 Airway Obstruction Respiratory Tract Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002994 BXGD000169 Angioedema Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004610 BXGD000281 Bacteremia Pathological Conditions, Signs and Symptoms; Infections
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010481 BXGD000673 Cushing Syndrome Endocrine System Diseases
C0011389 BXGD000718 Dental Plaque Stomatognathic Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0015526 BXGD001001 Factor XII Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0019207 BXGD001303 Hepatoma, Morris Digestive System Diseases; Neoplasms
C0019208 BXGD001304 Hepatoma, Novikoff Digestive System Diseases; Neoplasms
C0019243 BXGD001308 Angioedemas, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023283 BXGD001629 Leishmaniasis, Cutaneous Infections; Skin and Connective Tissue Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023904 BXGD001721 Liver Neoplasms, Experimental Digestive System Diseases; Neoplasms
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0030605 BXGD002248 Activated Partial Thromboplastin Time measurement
C0038034 BXGD002731 Sporotrichosis Infections; Skin and Connective Tissue Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040038 BXGD002837 Thromboembolism Cardiovascular Diseases
C0042109 BXGD002957 Urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0042487 BXGD002986 Venous Thrombosis Cardiovascular Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085096 BXGD003123 Peripheral Vascular Diseases Cardiovascular Diseases
C0086404 BXGD003278 Experimental Hepatoma Digestive System Diseases; Neoplasms
C0151563 BXGD003439 Prolonged whole-blood clotting time Hemic and Lymphatic Diseases
C0236024 BXGD004805 Edema of pharynx Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Immune System Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases; Cardiovascular Diseases
C0240671 BXGD005048 Partial thromboplastin time increased (finding)
C0241868 BXGD005118 acute aortic dissection Cardiovascular Diseases
C0272334 BXGD006349 Hereditary factor XII deficiency disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0275524 BXGD006376 Coinfection Infections
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0311370 BXGD006882 Lupus anticoagulant disorder Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0311468 BXGD006885 Increased bilirubin level (finding) Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0398623 BXGD008202 Thrombophilia Hemic and Lymphatic Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0429468 BXGD008651 Anovulatory (finding) Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0523465 BXGD009209 Serum albumin measurement
C0542571 BXGD009280 Facial edema Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases; Cardiovascular Diseases
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751956 BXGD010653 Acute Cerebrovascular Accidents Nervous System Diseases; Cardiovascular Diseases
C0883409 BXGD011395 Cardiac troponin I measurement
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1142262 BXGD011743 Intestinal edema Pathological Conditions, Signs and Symptoms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1611743 BXGD013456 Familial (FPAH)
C1629609 BXGD013479 Age at menopause
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1857728 BXGD015744 Hereditary Angioedema Type III Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1960459 BXGD016663 Hereditary angioedema with normal C1 esterase inhibitor activity Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2239219 BXGD016966 von Willebrand's factor (lab test)
C2697764 BXGD017434 Interleukin 16 Measurement
C2985280 BXGD018223 Blood Protein Measurement
C3808022 BXGD019536 Episodic abdominal pain Pathological Conditions, Signs and Symptoms
C4017222 BXGD020424 FACTOR XII (LOCARNO) PHENOTYPE
C4022978 BXGD021051 Episodic upper airway obstruction
C4303092 BXGD022550 Cystic echinococcosis Pathological Conditions, Signs and Symptoms; Neoplasms; Infections
C4529962 BXGD023178 Fatty Liver Disease
C4552292 BXGD023499 Hereditary angioedema with normal C1 esterase inhibitor Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C4552517 BXGD023514 Hereditary angioedema with normal C1 inhibitor
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002682 Zinc 65.41
BXGC0003456 1,4-Benzoquinone 108.09
BXGC0003705 Chloride 35.45
BXGC0004145 2,3-Heptanedione 128.17
BXGC0004206 3-Methyl-1,2-cyclopentanedione 112.13
BXGC0004245 2,3-Pentanedione 100.12
BXGC0004266 2-Propanol 60.1
BXGC0004280 2,4-Pentanedione 100.12
BXGC0004569 Benzophenone 182.22
BXGC0005049 4-Methylumbelliferyl acetate 218.21
BXGC0005697 2,3-Butanedione 86.09
BXGC0006021 3-Methyl-1,2-cyclohexanedione 126.15
BXGC0006271 L-Cysteine 121.16
BXGC0007060 1-Phenyl-1,2-propanedione 148.16
BXGC0010605 N-Malonylanthranilic acid 223.18
BXGC0033130 Benzoin 212.08
BXGC0033921 Isatin 147.03
BXGC0036541 Dibenzoylmethane 224.08
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein