adisease

Showing entry for Cushing Syndrome

General Disease Information
BXGD Id	BXGD000673
Disease Name	Cushing Syndrome
Disease CUI Id	C0010481
MeSH Codes	C19
Disease Class Name	Endocrine System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000818
Human Phenotype Ontology Term	Abnormality of the endocrine system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00255	BXGT003903	Menin	4221	reviewed
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O95263	BXGT005366	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	8622	reviewed
P00167	BXGT005473	Cytochrome b5	1528	reviewed	Enzyme
P00734	BXGT005630	Prothrombin	2147	reviewed	Enzyme
P00748	BXGT005640	Coagulation factor XII	2161	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01011	BXGT005715	Alpha-1-antichymotrypsin	12	reviewed	Enzyme modulator
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01215	BXGT005743	Glycoprotein hormones alpha chain	1081	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P02818	BXGT005969	Osteocalcin	632	reviewed
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04275	BXGT006180	von Willebrand factor	7450	reviewed	Enzyme modulator
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05093	BXGT006313	Steroid 17-alpha-hydroxylase/17,20 lyase	1586	reviewed
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07741	BXGT006666	Adenine phosphoribosyltransferase	353	reviewed
P07949	BXGT006703	Proto-oncogene tyrosine-protein kinase receptor Ret	5979	reviewed	Kinase
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08185	BXGT006742	Corticosteroid-binding globulin	866	reviewed	Enzyme modulator
P08235	BXGT006751	Mineralocorticoid receptor	4306	reviewed	Nuclear receptor
P08263	BXGT006759	Glutathione S-transferase A1	2938	reviewed
P08684	BXGT006812	Cytochrome P450 3A4	1576	reviewed	Enzyme
P08913	BXGT006841	Alpha-2A adrenergic receptor	150	reviewed	G-protein coupled receptor
P10109	BXGT007538	Adrenodoxin, mitochondrial	2230	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10599	BXGT007583	Thioredoxin	7295	reviewed
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P11597	BXGT007727	Cholesteryl ester transfer protein	1071	reviewed
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13647	BXGT007937	Keratin, type II cytoskeletal 5	3852	reviewed
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P15085	BXGT008077	Carboxypeptidase A1	1357	reviewed	Enzyme
P15121	BXGT008083	Aldo-keto reductase family 1 member B1	231	reviewed	Enzyme
P15538	BXGT008137	Cytochrome P450 11B1, mitochondrial	1584	reviewed
P16435	BXGT008226	NADPH--cytochrome P450 reductase	5447	reviewed
P17612	BXGT008322	cAMP-dependent protein kinase catalytic subunit alpha	5566	reviewed	Kinase
P19099	BXGT008456	Cytochrome P450 11B2, mitochondrial	1585	reviewed
P22694	BXGT008797	cAMP-dependent protein kinase catalytic subunit beta	5567	reviewed	Kinase
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24752	BXGT008993	Acetyl-CoA acetyltransferase, mitochondrial	38	reviewed	Enzyme
P25440	BXGT009044	Bromodomain-containing protein 2	6046	reviewed	Epigenetic regulator
P28845	BXGT009297	Corticosteroid 11-beta-dehydrogenase isozyme 1	3290	reviewed
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P32418	BXGT009635	Sodium/calcium exchanger 1	6546	reviewed	Transporter
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P48544	BXGT010641	G protein-activated inward rectifier potassium channel 4	3762	reviewed	Ion channel
P48546	BXGT010642	Gastric inhibitory polypeptide receptor	2696	reviewed	G-protein coupled receptor
P49327	BXGT010694	Fatty acid synthase	2194	reviewed	Enzyme
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P50052	BXGT010768	Type-2 angiotensin II receptor	186	reviewed	G-protein coupled receptor
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P80365	BXGT011895	Corticosteroid 11-beta-dehydrogenase isozyme 2	3291	reviewed	Enzyme
Q01094	BXGT012568	Transcription factor E2F1	1869	reviewed	Nucleic acid binding
Q01668	BXGT012605	Voltage-dependent L-type calcium channel subunit alpha-1D	776	reviewed	Ion channel
Q01718	BXGT012609	Adrenocorticotropic hormone receptor	4158	reviewed	G-protein coupled receptor
Q04609	BXGT012768	Glutamate carboxypeptidase 2	2346	reviewed	Enzyme
Q06520	BXGT012880	Bile salt sulfotransferase	6822	reviewed
Q13451	BXGT013356	Peptidyl-prolyl cis-trans isomerase FKBP5	2289	reviewed	Enzyme
Q13535	BXGT013370	Serine/threonine-protein kinase ATR	545	reviewed	Kinase
Q13639	BXGT013389	5-hydroxytryptamine receptor 4	3360	reviewed	G-protein coupled receptor
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q16445	BXGT013629	Gamma-aminobutyric acid receptor subunit alpha-6	2559	reviewed	Ion channel
Q9H227	BXGT020447	Cytosolic beta-glucosidase	57733	reviewed	Enzyme
Q9H251	BXGT020449	Cadherin-23	64072	reviewed
Q9H3M7	BXGT020462	Thioredoxin-interacting protein	10628	reviewed
Q9HCR9	BXGT020537	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	50940	reviewed
Q9UKV0	BXGT021750	Histone deacetylase 9	9734	reviewed	Epigenetic regulator
Q9UN36	BXGT021780	Protein NDRG2	57447	reviewed	Enzyme
Q92847	BXGT022673	Growth hormone secretagogue receptor type 1	2693	reviewed	G-protein coupled receptor
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
P07954	BXGT023939	Fumarate hydratase, mitochondrial	2271	reviewed	Enzyme
O95399	BXGT024237	Urotensin-2	10911	reviewed
Q08477	BXGT026164	Docosahexaenoic acid omega-hydroxylase CYP4F3	4051	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}