Showing entry for Phosphatidylcholine-sterol acyltransferase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006164
Protein NamePhosphatidylcholine-sterol acyltransferase
Uniport IdP04180
GeneLCAT
Gene Id3931
DomainLCAT
Pfam PF02450  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00564 Glycerophospholipid metabolism
5. Organismal Systems 5.4 Digestive system hsa04979 Cholesterol metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034435 cholesterol esterification
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0030301 cholesterol transport
Biological Process GO:0034375 high-density lipoprotein particle remodeling
Biological Process GO:0042158 lipoprotein biosynthetic process
Biological Process GO:0006656 phosphatidylcholine biosynthetic process
Biological Process GO:0046470 phosphatidylcholine metabolic process
Biological Process GO:0006644 phospholipid metabolic process
Biological Process GO:0090107 regulation of high-density lipoprotein particle assembly
Biological Process GO:0043691 reverse cholesterol transport
Biological Process GO:0034372 very-low-density lipoprotein particle remodeling
molecular function GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
molecular function GO:0034186 apolipoprotein A-I binding
molecular function GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity
molecular function GO:0047179 platelet-activating factor acetyltransferase activity
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0034364 high-density lipoprotein particle
Reactome
Pathway Id Pathway Name
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-382551 Transport of small molecules
R-HSA-8963899 Plasma lipoprotein remodeling
R-HSA-8964058 HDL remodeling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002878 BXGD000137 Anemia, Hemolytic Hemic and Lymphatic Diseases
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002962 BXGD000160 Angina Pectoris Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003742 BXGD000218 Arcus Senilis Eye Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005859 BXGD000342 Bloom Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0010038 BXGD000643 Corneal Opacity Eye Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0013238 BXGD000806 Dry Eye Syndromes Eye Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020474 BXGD001397 Hyperlipidemia, Familial Combined Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020476 BXGD001398 Hyperlipoproteinemias Nutritional and Metabolic Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023195 BXGD001614 Lecithin Acyltransferase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0023817 BXGD001706 Hyperlipoproteinemia Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024439 BXGD001773 Macular corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0025521 BXGD001876 Inborn Errors of Metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027888 BXGD002056 Hereditary Motor and Sensory Neuropathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0039292 BXGD002807 Tangier Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0151691 BXGD003460 Decreased HDL cholesterol concentration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0151718 BXGD003464 Hypocholesterolemia Nutritional and Metabolic Diseases
C0154251 BXGD003710 Lipid Metabolism Disorders Nutritional and Metabolic Diseases
C0155733 BXGD003815 Atherosclerosis of aorta Cardiovascular Diseases
C0178664 BXGD004032 Glomerulosclerosis (disorder) Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0235983 BXGD004798 Normochromic anemia Hemic and Lymphatic Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0263420 BXGD005303 Hyperkeratosis lenticularis perstans Skin and Connective Tissue Diseases
C0314719 BXGD006890 Dryness of eye Eye Diseases
C0342335 BXGD007461 insulin resistance in diabetes Nutritional and Metabolic Diseases
C0342883 BXGD007574 Cholesteryl Ester Transfer Protein Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0342895 BXGD007579 Fish-Eye Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0423250 BXGD008476 Corneal stromal opacities Eye Diseases
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0473527 BXGD008939 Hypoalphalipoproteinemias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0521719 BXGD009167 Clouding of corneal stroma Eye Diseases; Skin and Connective Tissue Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0549399 BXGD009376 Low density lipoprotein increased Nutritional and Metabolic Diseases
C0577631 BXGD009535 Carotid Atherosclerosis Nervous System Diseases; Cardiovascular Diseases
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0860204 BXGD011219 Cholestatic liver disease Digestive System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1536220 BXGD013341 ST segment elevation myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1611743 BXGD013456 Familial (FPAH)
C1636149 BXGD013482 Macular dystrophy, corneal type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1704429 BXGD013561 Hypoalphalipoproteinemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3160761 BXGD018475 Diabetic dyslipidaemia
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665365 BXGD019282 Arteriosclerotic cardiovascular disease, NOS Cardiovascular Diseases
C3711531 BXGD019395 Hdl Deficiency, Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4021729 BXGD020738 Increased VLDL cholesterol concentration Nutritional and Metabolic Diseases
C4087498 BXGD022154 Familial LCAT deficiency
C4281786 BXGD022416 Presence of foam cells Cardiovascular Diseases
C4524040 BXGD023086 Atherogenic dyslipidaemia
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein