Showing entry for Inhibin beta A chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006774
Protein NameInhibin beta A chain
Uniport IdP08476
GeneINHBA
Gene Id3624
DomainTGFb_propeptide; TGF_beta
Pfam PF00019   PF00688  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.2 Signal transduction hsa04350 TGF-beta signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032924 activin receptor signaling pathway
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0030154 cell differentiation
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0071397 cellular response to cholesterol
Biological Process GO:0071372 cellular response to follicle-stimulating hormone stimulus
Biological Process GO:0006952 defense response
Biological Process GO:0035987 endodermal cell differentiation
Biological Process GO:0030218 erythrocyte differentiation
Biological Process GO:0097191 extrinsic apoptotic signaling pathway
Biological Process GO:0061029 eyelid development in camera-type eye
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0097154 GABAergic neuron differentiation
Biological Process GO:0001942 hair follicle development
Biological Process GO:0002244 hematopoietic progenitor cell differentiation
Biological Process GO:0042541 hemoglobin biosynthetic process
Biological Process GO:0008584 male gonad development
Biological Process GO:0048333 mesodermal cell differentiation
Biological Process GO:0045578 negative regulation of B cell differentiation
Biological Process GO:0045786 negative regulation of cell cycle
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0046882 negative regulation of follicle-stimulating hormone secretion
Biological Process GO:0032689 negative regulation of interferon-gamma production
Biological Process GO:0045650 negative regulation of macrophage differentiation
Biological Process GO:0042326 negative regulation of phosphorylation
Biological Process GO:0007399 nervous system development
Biological Process GO:0042476 odontogenesis
Biological Process GO:0001541 ovarian follicle development
Biological Process GO:0032270 positive regulation of cellular protein metabolic process
Biological Process GO:0045648 positive regulation of erythrocyte differentiation
Biological Process GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Process GO:0046881 positive regulation of follicle-stimulating hormone secretion
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0060279 positive regulation of ovulation
Biological Process GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0042701 progesterone secretion
Biological Process GO:0046880 regulation of follicle-stimulating hormone secretion
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0042493 response to drug
Biological Process GO:0060021 roof of mouth development
Biological Process GO:0060395 SMAD protein signal transduction
Biological Process GO:0021773 striatal medium spiny neuron differentiation
molecular function GO:0005125 cytokine activity
molecular function GO:0008083 growth factor activity
molecular function GO:0005179 hormone activity
molecular function GO:0042802 identical protein binding
molecular function GO:0034711 inhibin binding
molecular function GO:0017046 peptide hormone binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0070699 type II activin receptor binding
cellular component GO:0043509 activin A complex
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0043512 inhibin A complex
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1502540 Signaling by Activin
R-HSA-1502540 Signaling by Activin
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-209822 Glycoprotein hormones
R-HSA-209952 Peptide hormone biosynthesis
R-HSA-2473224 Antagonism of Activin by Follistatin
R-HSA-2980736 Peptide hormone metabolism
R-HSA-392499 Metabolism of proteins
R-HSA-9006936 Signaling by TGFB family members
R-HSA-9006936 Signaling by TGFB family members
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000731 BXGD000002 Abdomen distended Digestive System Diseases
C0000734 BXGD000003 Abdominal mass Digestive System Diseases
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0003962 BXGD000244 Ascites Pathological Conditions, Signs and Symptoms
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0013390 BXGD000828 Dysmenorrhea Pathological Conditions, Signs and Symptoms
C0013537 BXGD000853 Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0014170 BXGD000902 Endometrial Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0021843 BXGD001520 Intestinal Obstruction Digestive System Diseases
C0022735 BXGD001581 Klinefelter Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025323 BXGD001864 Menorrhagia Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027497 BXGD001993 Nausea Pathological Conditions, Signs and Symptoms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0032227 BXGD002336 Pleural effusion disorder Respiratory Tract Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032914 BXGD002379 Pre-Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0035435 BXGD002549 Rheumatism Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0040038 BXGD002837 Thromboembolism Cardiovascular Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0042138 BXGD002962 Uterine Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0085606 BXGD003201 Urgency of micturition Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153567 BXGD003665 Uterine Cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0162557 BXGD003956 Liver Failure, Acute Digestive System Diseases
C0206650 BXGD004214 Fibroadenoma Neoplasms
C0206681 BXGD004236 Adenocarcinoma, Clear Cell Neoplasms
C0232466 BXGD004543 Feeding difficulties
C0235592 BXGD004758 Cervical lymphadenopathy Hemic and Lymphatic Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0333519 BXGD006958 Caries (morphologic abnormality) Pathological Conditions, Signs and Symptoms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948216 BXGD011517 Ovarian adenocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1275122 BXGD012060 Familial multiple trichoepitheliomata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1335168 BXGD012769 Ovarian mucinous tumor
C1511789 BXGD013183 Desmoplastic
C1838993 BXGD014351 Episodic vomiting Pathological Conditions, Signs and Symptoms
C2145472 BXGD016931 Urothelial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347748 BXGD017041 Adult Erythroleukemia
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3808022 BXGD019536 Episodic abdominal pain Pathological Conditions, Signs and Symptoms
C4024979 BXGD021510 Ovarian papillary adenocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4476917 BXGD022889 Elevated carcinoembryonic antigen level
C4476918 BXGD022890 Elevated carcinoma antigen 125 level
C4520840 BXGD023041 Erythroleukemia (Erythroid/Myeloid) Neoplasms; Hemic and Lymphatic Diseases
C4553976 BXGD023554 Urinary Urgency, CTCAE 5
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein