adisease

Showing entry for Fibroid Tumor

General Disease Information
BXGD Id	BXGD001626
Disease Name	Fibroid Tumor
Disease CUI Id	C0023267
MeSH Codes	C04
Disease Class Name	Neoplasms
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:7 DOID:14566
Disease Ontology Class Name	disease of anatomical entity; disease of cellular proliferation
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O00255	BXGT003903	Menin	4221	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00755	BXGT003945	Protein Wnt-7a	7476	reviewed	Signaling
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O14920	BXGT004110	Inhibitor of nuclear factor kappa-B kinase subunit beta	3551	reviewed	Kinase
O15123	BXGT004130	Angiopoietin-2	285	reviewed	Signaling
O15527	BXGT004176	N-glycosylase/DNA lyase	4968	reviewed
O43278	BXGT004581	Kunitz-type protease inhibitor 1	6692	reviewed
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O75173	BXGT005105	A disintegrin and metalloproteinase with thrombospondin motifs 4	9507	reviewed	Enzyme
O75223	BXGT005106	Gamma-glutamylcyclotransferase	79017	reviewed
P00352	BXGT005510	Retinal dehydrogenase 1	216	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00918	BXGT005690	Carbonic anhydrase 2	760	reviewed
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01148	BXGT005739	Progonadoliberin-1	2796	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02452	BXGT005878	Collagen alpha-1(I) chain	1277	reviewed
P02461	BXGT005880	Collagen alpha-1(III) chain	1281	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04275	BXGT006180	von Willebrand factor	7450	reviewed	Enzyme modulator
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P04406	BXGT006207	Glyceraldehyde-3-phosphate dehydrogenase	2597	reviewed	Enzyme
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04798	BXGT006265	Cytochrome P450 1A1	1543	reviewed	Enzyme
P05093	BXGT006313	Steroid 17-alpha-hydroxylase/17,20 lyase	1586	reviewed
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05230	BXGT006344	Fibroblast growth factor 1	2246	reviewed	Signaling
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05556	BXGT006368	Integrin beta-1	3688	reviewed	Receptor
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P06401	BXGT006436	Progesterone receptor	5241	reviewed	Nuclear receptor
P06756	BXGT006499	Integrin alpha-V	3685	reviewed
P07108	BXGT006551	Acyl-CoA-binding protein	1622	reviewed	Enzyme modulator
P07711	BXGT006661	Cathepsin L1	1514	reviewed	Enzyme
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08151	BXGT006731	Zinc finger protein GLI1	2735	reviewed
P08195	BXGT006745	4F2 cell-surface antigen heavy chain	6520	reviewed	Transporter
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08473	BXGT006773	Neprilysin	4311	reviewed	Enzyme
P08476	BXGT006774	Inhibin beta A chain	3624	reviewed	Signaling
P08833	BXGT006827	Insulin-like growth factor-binding protein 1	3484	reviewed	Enzyme modulator
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09455	BXGT006890	Retinol-binding protein 1	5947	reviewed
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09769	BXGT006917	Tyrosine-protein kinase Fgr	2268	reviewed	Kinase
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P0DMV8	BXGT007509	Heat shock 70 kDa protein 1A	3304	reviewed
P0DMV9	BXGT007510	Heat shock 70 kDa protein 1B	3304	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10599	BXGT007583	Thioredoxin	7295	reviewed
P10600	BXGT007584	Transforming growth factor beta-3 proprotein	7043	reviewed	Signaling
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P11137	BXGT007656	Microtubule-associated protein 2	4133	reviewed
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P12830	BXGT007852	Cadherin-1	999	reviewed
P12931	BXGT007859	Proto-oncogene tyrosine-protein kinase Src	6714	reviewed	Kinase
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P14672	BXGT008037	Solute carrier family 2, facilitated glucose transporter member 4	6517	reviewed	Transporter
P14921	BXGT008068	Protein C-ets-1	2113	reviewed	Transcription factor
P15121	BXGT008083	Aldo-keto reductase family 1 member B1	231	reviewed	Enzyme
P15169	BXGT008093	Carboxypeptidase N catalytic chain	1369	reviewed
P15428	BXGT008121	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	3248	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16070	BXGT008186	CD44 antigen	960	reviewed
P16234	BXGT008209	Platelet-derived growth factor receptor alpha	5156	reviewed	Kinase
P16471	BXGT008233	Prolactin receptor	5618	reviewed	Signaling
P17301	BXGT008299	Integrin alpha-2	3673	reviewed
P17676	BXGT008327	CCAAT/enhancer-binding protein beta	1051	reviewed	Transcription factor
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18146	BXGT008384	Early growth response protein 1	1958	reviewed	Nucleic acid binding
P18669	BXGT008419	Phosphoglycerate mutase 1	5223	reviewed
P18847	BXGT008431	Cyclic AMP-dependent transcription factor ATF-3	467	reviewed	Transcription factor
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P19793	BXGT008515	Retinoic acid receptor RXR-alpha	6256	reviewed	Nuclear receptor
P19883	BXGT008528	Follistatin	10468	reviewed	Enzyme modulator
P20132	BXGT008546	L-serine dehydratase/L-threonine deaminase	10993	reviewed	Enzyme
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P21452	BXGT008653	Substance-K receptor	6865	reviewed	G-protein coupled receptor
P21728	BXGT008686	D(1A) dopamine receptor	1812	reviewed	G-protein coupled receptor
P21860	BXGT008698	Receptor tyrosine-protein kinase erbB-3	2065	reviewed	Kinase
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P22792	BXGT008807	Carboxypeptidase N subunit 2	1370	reviewed	Receptor
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P24666	BXGT008986	Low molecular weight phosphotyrosine protein phosphatase	52	reviewed
P24941	BXGT009002	Cyclin-dependent kinase 2	1017	reviewed	Kinase
P25024	BXGT009005	C-X-C chemokine receptor type 1	3577	reviewed	G-protein coupled receptor
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P25103	BXGT009020	Substance-P receptor	6869	reviewed	G-protein coupled receptor
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P26447	BXGT009114	Protein S100-A4	6275	reviewed	Calcium-binding protein
P27540	BXGT009190	Aryl hydrocarbon receptor nuclear translocator	405	reviewed	Transcription factor
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P29400	BXGT009343	Collagen alpha-5(IV) chain	1287	reviewed
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P30086	BXGT009400	Phosphatidylethanolamine-binding protein 1	5037	reviewed	Enzyme modulator
P30279	BXGT009415	G1/S-specific cyclin-D2	894	reviewed	Enzyme modulator
P30559	BXGT009442	Oxytocin receptor	5021	reviewed	G-protein coupled receptor
P31260	BXGT009519	Homeobox protein Hox-A10	3206	reviewed
P31751	BXGT009576	RAC-beta serine/threonine-protein kinase	208	reviewed	Kinase
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35442	BXGT009832	Thrombospondin-2	7058	reviewed
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P35590	BXGT009854	Tyrosine-protein kinase receptor Tie-1	7075	reviewed	Kinase
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36897	BXGT009941	TGF-beta receptor type-1	7046	reviewed	Kinase
P37059	BXGT009957	Estradiol 17-beta-dehydrogenase 2	3294	reviewed	Enzyme
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38936	BXGT010074	Cyclin-dependent kinase inhibitor 1	1026	reviewed
P41182	BXGT010231	B-cell lymphoma 6 protein	604	reviewed
P41273	BXGT010251	Tumor necrosis factor ligand superfamily member 9	8744	reviewed
P42262	BXGT010294	Glutamate receptor 2	2891	reviewed	Ion channel
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P43246	BXGT010371	DNA mismatch repair protein Msh2	4436	reviewed	Nucleic acid binding
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49683	BXGT010726	Prolactin-releasing peptide receptor	2834	reviewed	G-protein coupled receptor
P50052	BXGT010768	Type-2 angiotensin II receptor	186	reviewed	G-protein coupled receptor
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P53355	BXGT010985	Death-associated protein kinase 1	1612	reviewed	Kinase
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61981	BXGT011400	14-3-3 protein gamma	7532	reviewed	Chaperone
P62993	BXGT011480	Growth factor receptor-bound protein 2	2885	reviewed
P63261	BXGT011512	Actin, cytoplasmic 2	71	reviewed	Cellular structure
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
Q00796	BXGT012549	Sorbitol dehydrogenase	6652	reviewed	Enzyme
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q01650	BXGT012603	Large neutral amino acids transporter small subunit 1	8140	reviewed	Transporter
Q01831	BXGT012621	DNA repair protein complementing XP-C cells	7508	reviewed	Nucleic acid binding
Q02763	BXGT012667	Angiopoietin-1 receptor	7010	reviewed	Kinase
Q06828	BXGT012893	Fibromodulin	2331	reviewed
Q07812	BXGT012940	Apoptosis regulator BAX	581	reviewed	Signaling
Q07820	BXGT012942	Induced myeloid leukemia cell differentiation protein Mcl-1	4170	reviewed	Signaling
Q13426	BXGT013353	DNA repair protein XRCC4	7518	reviewed
Q13427	BXGT013354	Peptidyl-prolyl cis-trans isomerase G	9360	reviewed
Q13478	BXGT013362	Interleukin-18 receptor 1	8809	reviewed	Receptor
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14332	BXGT013462	Frizzled-2	2535	reviewed	G-protein coupled receptor
Q14416	BXGT013468	Metabotropic glutamate receptor 2	2912	reviewed	G-protein coupled receptor
Q14457	BXGT013472	Beclin-1	8678	reviewed	Enzyme modulator
Q15125	BXGT013543	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	10682	reviewed	Enzyme
Q15389	BXGT013564	Angiopoietin-1	284	reviewed	Signaling
Q15392	BXGT013566	Delta(24)-sterol reductase	1718	reviewed	Enzyme
Q15465	BXGT013573	Sonic hedgehog protein	6469	reviewed
Q15596	BXGT013582	Nuclear receptor coactivator 2	10499	reviewed	Enzyme
Q15746	BXGT013591	Myosin light chain kinase, smooth muscle	4638	reviewed	Kinase
Q15788	BXGT013598	Nuclear receptor coactivator 1	8648	reviewed	Kinase
Q15796	BXGT013599	Mothers against decapentaplegic homolog 2	4087	reviewed	Transcription factor
Q15831	BXGT013604	Serine/threonine-protein kinase STK11	6794	reviewed	Kinase
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16611	BXGT013644	Bcl-2 homologous antagonist/killer	578	reviewed	Signaling
Q16637	BXGT013646	Survival motor neuron protein	6607	reviewed	Epigenetic regulator
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16678	BXGT013656	Cytochrome P450 1B1	1545	reviewed	Enzyme
Q53EL6	BXGT015008	Programmed cell death protein 4	27250	reviewed	Nucleic acid binding
Q6ZQY3	BXGT016636	Acidic amino acid decarboxylase GADL1	339896	reviewed
Q7Z3B3	BXGT017249	KAT8 regulatory NSL complex subunit 1	284058	reviewed
Q8TDS4	BXGT018812	Hydroxycarboxylic acid receptor 2	338442	reviewed
Q8WXD0	BXGT019009	Relaxin receptor 2	122042	reviewed	G-protein coupled receptor
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q96A70	BXGT019615	Antizyme inhibitor 2	113451	reviewed	Enzyme
Q96AC1	BXGT019617	Fermitin family homolog 2	10979	reviewed
Q96PN6	BXGT019709	Adenylate cyclase type 10	55811	reviewed
Q96RE7	BXGT019725	Nucleus accumbens-associated protein 1	112939	reviewed
Q99527	BXGT019930	G-protein coupled estrogen receptor 1	2852	reviewed	G-protein coupled receptor
Q9BY41	BXGT020180	Histone deacetylase 8	55869	reviewed	Epigenetic regulator
Q9HBX9	BXGT020523	Relaxin receptor 1	59350	reviewed	G-protein coupled receptor
Q9NYB9	BXGT021256	Abl interactor 2	10152	reviewed	Enzyme modulator
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UBN7	BXGT021658	Histone deacetylase 6	10013	reviewed	Epigenetic regulator
Q9UHF0	BXGT021699	Tachykinin-3	6866	reviewed
Q9UHI5	BXGT021700	Large neutral amino acids transporter small subunit 2	23428	reviewed	Transporter
Q9UKV8	BXGT021752	Protein argonaute-2	27161	reviewed
Q9UM73	BXGT021773	ALK tyrosine kinase receptor	238	reviewed	Kinase
Q9Y243	BXGT022214	RAC-gamma serine/threonine-protein kinase	10000	reviewed	Kinase
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
Q9Y618	BXGT022315	Nuclear receptor corepressor 2	9612	reviewed	Transcription factor
Q9Y657	BXGT022318	Spindlin-1	10927	reviewed
Q9Y6K1	BXGT022331	DNA (cytosine-5)-methyltransferase 3A	1788	reviewed
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
O14793	BXGT023280	Growth/differentiation factor 8	2660	reviewed	Signaling
P07954	BXGT023939	Fumarate hydratase, mitochondrial	2271	reviewed	Enzyme
Q12888	BXGT024878	TP53-binding protein 1	7158	reviewed	Epigenetic regulator
Q13635	BXGT024910	Protein patched homolog 1	5727	reviewed
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme
Q08477	BXGT026164	Docosahexaenoic acid omega-hydroxylase CYP4F3	4051	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}