Showing entry for Familial multiple trichoepitheliomata


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD012060
Disease NameFamilial multiple trichoepitheliomata
Disease CUI IdC1275122
MeSH Codes C16   C04   C17  
Disease Class NameCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00182 BXGT003889 Galectin-9 3965 reviewed Signaling
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O14672 BXGT004081 Disintegrin and metalloproteinase domain-containing protein 10 102 reviewed
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O43570 BXGT004601 Carbonic anhydrase 12 771 reviewed
O60218 BXGT004858 Aldo-keto reductase family 1 member B10 57016 reviewed Enzyme
O75751 BXGT005150 Solute carrier family 22 member 3 6581 reviewed Transporter
O94788 BXGT005333 Retinal dehydrogenase 2 8854 reviewed Enzyme
O94907 BXGT005340 Dickkopf-related protein 1 22943 reviewed
O95256 BXGT005364 Interleukin-18 receptor accessory protein 8807 reviewed Receptor
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00918 BXGT005690 Carbonic anhydrase 2 760 reviewed
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P02452 BXGT005878 Collagen alpha-1(I) chain 1277 reviewed
P02748 BXGT005940 Complement component C9 735 reviewed
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04083 BXGT006147 Annexin A1 301 reviewed
P04155 BXGT006155 Trefoil factor 1 7031 reviewed Signaling
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P05093 BXGT006313 Steroid 17-alpha-hydroxylase/17,20 lyase 1586 reviewed
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05412 BXGT006354 Transcription factor AP-1 3725 reviewed Transcription factor
P06396 BXGT006435 Gelsolin 2934 reviewed Cellular structure
P06401 BXGT006436 Progesterone receptor 5241 reviewed Nuclear receptor
P06702 BXGT006476 Protein S100-A9 6280 reviewed Calcium-binding protein
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P07148 BXGT006559 Fatty acid-binding protein, liver 2168 reviewed
P07858 BXGT006689 Cathepsin B 1508 reviewed Enzyme
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08151 BXGT006731 Zinc finger protein GLI1 2735 reviewed
P08174 BXGT006739 Complement decay-accelerating factor 1604 reviewed
P08246 BXGT006756 Neutrophil elastase 1991 reviewed Enzyme
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P08476 BXGT006774 Inhibin beta A chain 3624 reviewed Signaling
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C 5788 reviewed Enzyme
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P0CG29 BXGT007465 Glutathione S-transferase theta-2 2953 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P11802 BXGT007750 Cyclin-dependent kinase 4 1019 reviewed Kinase
P12830 BXGT007852 Cadherin-1 999 reviewed
P14625 BXGT008029 Endoplasmin 7184 reviewed Chaperone
P14902 BXGT008065 Indoleamine 2,3-dioxygenase 1 3620 reviewed
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16455 BXGT008229 Methylated-DNA--protein-cysteine methyltransferase 4255 reviewed
P17936 BXGT008357 Insulin-like growth factor-binding protein 3 3486 reviewed Enzyme modulator
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P18283 BXGT008395 Glutathione peroxidase 2 2877 reviewed Enzyme
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P21860 BXGT008698 Receptor tyrosine-protein kinase erbB-3 2065 reviewed Kinase
P22083 BXGT008727 Alpha-(1,3)-fucosyltransferase 4 2526 reviewed Enzyme
P22607 BXGT008784 Fibroblast growth factor receptor 3 2261 reviewed Kinase
P23219 BXGT008837 Prostaglandin G/H synthase 1 5742 reviewed Enzyme
P23443 BXGT008866 Ribosomal protein S6 kinase beta-1 6198 reviewed Kinase
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase 328 reviewed
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29372 BXGT009336 DNA-3-methyladenine glycosylase 4350 reviewed Enzyme
P29508 BXGT009358 Serpin B3 6317 reviewed Enzyme modulator
P30530 BXGT009431 Tyrosine-protein kinase receptor UFO 558 reviewed Kinase
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P32239 BXGT009612 Gastrin/cholecystokinin type B receptor 887 reviewed G-protein coupled receptor
P33681 BXGT009739 T-lymphocyte activation antigen CD80 941 reviewed
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P36551 BXGT009927 Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial 1371 reviewed Enzyme
P36955 BXGT009946 Pigment epithelium-derived factor 5176 reviewed Enzyme modulator
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41235 BXGT010241 Hepatocyte nuclear factor 4-alpha 3172 reviewed Nuclear receptor
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P46108 BXGT010509 Adapter molecule crk 1398 reviewed
P47736 BXGT010579 Rap1 GTPase-activating protein 1 5909 reviewed Enzyme modulator
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
P49862 BXGT010752 Kallikrein-7 5650 reviewed Enzyme
P50750 BXGT010818 Cyclin-dependent kinase 9 1025 reviewed Kinase
P51161 BXGT010841 Gastrotropin 2172 reviewed
P51449 BXGT010846 Nuclear receptor ROR-gamma 6097 reviewed Nuclear receptor
P55042 BXGT011100 GTP-binding protein RAD 6236 reviewed
P55210 BXGT011110 Caspase-7 840 reviewed Enzyme
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P62834 BXGT011464 Ras-related protein Rap-1A 5906 reviewed Enzyme modulator
P63000 BXGT011481 Ras-related C3 botulinum toxin substrate 1 5879 reviewed Enzyme modulator
P78527 BXGT011846 DNA-dependent protein kinase catalytic subunit 5591 reviewed Kinase
P98170 BXGT012231 E3 ubiquitin-protein ligase XIAP 331 reviewed Enzyme modulator
Q00534 BXGT012533 Cyclin-dependent kinase 6 1021 reviewed Kinase
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q01196 BXGT012575 Runt-related transcription factor 1 861 reviewed Transcription factor
Q02790 BXGT012672 Peptidyl-prolyl cis-trans isomerase FKBP4 2288 reviewed Enzyme
Q04637 BXGT012771 Eukaryotic translation initiation factor 4 gamma 1 1981 reviewed Nucleic acid binding
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 4170 reviewed Signaling
Q08881 BXGT013012 Tyrosine-protein kinase ITK/TSK 3702 reviewed Kinase
Q12908 BXGT013278 Ileal sodium/bile acid cotransporter 6555 reviewed Transporter
Q13155 BXGT013320 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 7965 reviewed
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13451 BXGT013356 Peptidyl-prolyl cis-trans isomerase FKBP5 2289 reviewed Enzyme
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q13555 BXGT013375 Calcium/calmodulin-dependent protein kinase type II subunit gamma 818 reviewed Kinase
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14240 BXGT013458 Eukaryotic initiation factor 4A-II 1974 reviewed
Q14457 BXGT013472 Beclin-1 8678 reviewed Enzyme modulator
Q14680 BXGT013499 Maternal embryonic leucine zipper kinase 9833 reviewed Kinase
Q15652 BXGT013587 Probable JmjC domain-containing histone demethylation protein 2C 221037 reviewed
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 6794 reviewed Kinase
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q16539 BXGT013634 Mitogen-activated protein kinase 14 1432 reviewed Kinase
Q16790 BXGT013670 Carbonic anhydrase 9 768 reviewed
Q16828 BXGT013676 Dual specificity protein phosphatase 6 1848 reviewed
Q5VWK5 BXGT015891 Interleukin-23 receptor 149233 reviewed Signaling
Q8TDU6 BXGT018814 G-protein coupled bile acid receptor 1 151306 reviewed G-protein coupled receptor
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q96NY9 BXGT019703 Crossover junction endonuclease MUS81 80198 reviewed
Q96T88 BXGT019747 E3 ubiquitin-protein ligase UHRF1 29128 reviewed
Q99593 BXGT019939 T-box transcription factor TBX5 6910 reviewed Transcription factor
Q99835 BXGT019969 Smoothened homolog 6608 reviewed G-protein coupled receptor
Q9GZT4 BXGT020424 Serine racemase 63826 reviewed Enzyme
Q9H3M7 BXGT020462 Thioredoxin-interacting protein 10628 reviewed
Q9NP79 BXGT021145 Vacuolar protein sorting-associated protein VTA1 homolog 51534 reviewed
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9P212 BXGT021297 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 51196 reviewed Enzyme
Q9UDX4 BXGT021669 SEC14-like protein 3 266629 reviewed
Q9UJ41 BXGT021723 Rab5 GDP/GTP exchange factor 27342 reviewed Enzyme modulator
Q9Y3B4 BXGT022255 Splicing factor 3B subunit 6 51639 reviewed
Q9Y5W5 BXGT022303 Wnt inhibitory factor 1 11197 reviewed Calcium-binding protein
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
P16284 BXGT022972 Platelet endothelial cell adhesion molecule 5175 reviewed Cell adhesion
Q9GZQ8 BXGT023414 Microtubule-associated proteins 1A/1B light chain 3B 81631 reviewed Cellular structure
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P00395 BXGT023596 Cytochrome c oxidase subunit 1 4512 reviewed Enzyme
Q92832 BXGT025242 Protein kinase C-binding protein NELL1 4745 reviewed Calcium-binding protein
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease