Showing entry for Tyrosine-protein kinase HCK


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006801
Protein NameTyrosine-protein kinase HCK
Uniport IdP08631
GeneHCK
Gene Id3055
DomainPkinase_Tyr; SH2; SH3_1
Pfam PF07714   PF00017   PF00018  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
5. Organismal Systems 5.1 Immune system hsa04666 Fc gamma R-mediated phagocytosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05167 Kaposi sarcoma-associated herpesvirus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007155 cell adhesion
Biological Process GO:0030154 cell differentiation
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0002758 innate immune response-activating signal transduction
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0060333 interferon-gamma-mediated signaling pathway
Biological Process GO:0043299 leukocyte degranulation
Biological Process GO:0002522 leukocyte migration involved in immune response
Biological Process GO:0031663 lipopolysaccharide-mediated signaling pathway
Biological Process GO:0007498 mesoderm development
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0038083 peptidyl-tyrosine autophosphorylation
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:2000251 positive regulation of actin cytoskeleton reorganization
Biological Process GO:0030838 positive regulation of actin filament polymerization
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0050690 regulation of defense response to virus by virus
Biological Process GO:0051090 regulation of DNA-binding transcription factor activity
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0050764 regulation of phagocytosis
Biological Process GO:0071801 regulation of podosome assembly
Biological Process GO:0045728 respiratory burst after phagocytosis
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0004715 non-membrane spanning protein tyrosine kinase activity
molecular function GO:0001784 phosphotyrosine residue binding
molecular function GO:0004713 protein tyrosine kinase activity
molecular function GO:0005102 signaling receptor binding
cellular component GO:0005901 caveola
cellular component GO:0042995 cell projection
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
cellular component GO:0005925 focal adhesion
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005764 lysosome
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0030133 transport vesicle
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162906 HIV Infection
R-HSA-162909 Host Interactions of HIV factors
R-HSA-1643685 Disease
R-HSA-164944 Nef and signal transduction
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-2029481 FCGR activation
R-HSA-449147 Signaling by Interleukins
R-HSA-449147 Signaling by Interleukins
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5663205 Infectious disease
R-HSA-912631 Regulation of signaling by CBL
R-HSA-912631 Regulation of signaling by CBL
R-HSA-9607240 FLT3 Signaling
R-HSA-9658195 Leishmania infection
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664323 FCGR3A-mediated IL10 synthesis
R-HSA-9664407 Parasite infection
R-HSA-9664417 Leishmania phagocytosis
R-HSA-9664422 FCGR3A-mediated phagocytosis
R-HSA-9664433 Leishmania parasite growth and survival
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001849 BXGD000084 AIDS Dementia Complex Infections; Immune System Diseases; Nervous System Diseases; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023453 BXGD001652 L2 Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024419 BXGD001769 Waldenstrom Macroglobulinemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0032461 BXGD002356 Polycythemia Hemic and Lymphatic Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0238790 BXGD004956 bone destruction
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0409952 BXGD008399 Idiopathic osteoarthritis Musculoskeletal Diseases
C0523465 BXGD009209 Serum albumin measurement
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0920028 BXGD011454 Leukaemia recurrent Neoplasms
C0949541 BXGD011578 Hurthle Cell Tumor Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1305855 BXGD012348 Body mass index
C1335167 BXGD012768 Ovarian Mucinous Adenocarcinoma Neoplasms
C1378050 BXGD012931 Oncocytic Neoplasm
C1384584 BXGD012943 Generalized osteoarthritis Musculoskeletal Diseases
C1456246 BXGD013110 Bacteroides fragilis infection in conditions classified elsewhere and of unspecified site
C1510502 BXGD013175 Oxyphilic Adenoma Neoplasms
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2363741 BXGD017100 HIV-1 infection
C2985280 BXGD018223 Blood Protein Measurement
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3714514 BXGD019409 Infection Infections
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
BXGC0005683 Quercetin 302.24
BXGC0006109 2-Aminoquinoline 144.17
BXGC0012352 Chelerythrine 348.12
BXGC0013109 4-[2-(3,5-Dihydroxyphenyl)Ethenyl]Benzene-1,2-Diol 244.07
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein