Showing entry for DNA polymerase alpha catalytic subunit


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006937
Protein NameDNA polymerase alpha catalytic subunit
Uniport IdP09884
GenePOLA1
Gene Id5422
DomainDNA_pol_alpha_N; DNA_pol_B; DNA_pol_B_exo1; zf-DNA_Pol
Pfam PF12254   PF00136   PF03104   PF08996  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03030 DNA replication
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006281 DNA repair
Biological Process GO:0006260 DNA replication
Biological Process GO:0006269 DNA replication, synthesis of RNA primer
Biological Process GO:0006270 DNA replication initiation
Biological Process GO:0006271 DNA strand elongation involved in DNA replication
Biological Process GO:0000731 DNA synthesis involved in DNA repair
Biological Process GO:0006303 double-strand break repair via nonhomologous end joining
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0006273 lagging strand elongation
Biological Process GO:0006272 leading strand elongation
Biological Process GO:1902975 mitotic DNA replication initiation
Biological Process GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
Biological Process GO:0032479 regulation of type I interferon production
Biological Process GO:0032201 telomere maintenance via semi-conservative replication
Biological Process GO:0016032 viral process
molecular function GO:0051539 4 iron, 4 sulfur cluster binding
molecular function GO:0003682 chromatin binding
molecular function GO:0003677 DNA binding
molecular function GO:0003887 DNA-directed DNA polymerase activity
molecular function GO:0003688 DNA replication origin binding
molecular function GO:0046872 metal ion binding
molecular function GO:0000166 nucleotide binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0017076 purine nucleotide binding
molecular function GO:0019103 pyrimidine nucleotide binding
molecular function GO:0003697 single-stranded DNA binding
cellular component GO:0005658 alpha DNA polymerase:primase complex
cellular component GO:0005829 cytosol
cellular component GO:0005635 nuclear envelope
cellular component GO:0016363 nuclear matrix
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-HSA-113510 E2F mediated regulation of DNA replication
R-HSA-157579 Telomere Maintenance
R-HSA-1640170 Cell Cycle
R-HSA-174411 Polymerase switching on the C-strand of the telomere
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis
R-HSA-174430 Telomere C-strand synthesis initiation
R-HSA-180786 Extension of Telomeres
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-68952 DNA replication initiation
R-HSA-68962 Activation of the pre-replicative complex
R-HSA-69002 DNA Replication Pre-Initiation
R-HSA-69091 Polymerase switching
R-HSA-69109 Leading Strand Synthesis
R-HSA-69166 Removal of the Flap Intermediate
R-HSA-69183 Processive synthesis on the lagging strand
R-HSA-69186 Lagging Strand Synthesis
R-HSA-69190 DNA strand elongation
R-HSA-69205 G1/S-Specific Transcription
R-HSA-69206 G1/S Transition
R-HSA-69239 Synthesis of DNA
R-HSA-69242 S Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69306 DNA Replication
R-HSA-73886 Chromosome Maintenance
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007939 BXGD000505 Syphilitic chancre Infections
C0009319 BXGD000596 Colitis Digestive System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018991 BXGD001264 Hemiplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0020620 BXGD001448 Hypohidrosis Skin and Connective Tissue Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037020 BXGD002659 Shyness Behavior and Behavior Mechanisms
C0039128 BXGD002794 Syphilis Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0041974 BXGD002945 Urethral Stenosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0080174 BXGD003106 Spina Bifida Occulta Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0238397 BXGD004923 Pulmonary artery stenosis Cardiovascular Diseases
C0242855 BXGD005198 Congenital atresia of pulmonary valve Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0280790 BXGD006763 Adult Anaplastic Oligodendroglioma Neoplasms
C0334590 BXGD007129 Anaplastic Oligodendroglioma Neoplasms
C0348148 BXGD007867 Early syphilis, unspecified Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0349588 BXGD007933 Short stature
C0349702 BXGD007951 Corneal Scar Eye Diseases; Nervous System Diseases; Wounds and Injuries
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0410174 BXGD008410 Fukuyama Type Congenital Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0423109 BXGD008470 Upward slant of palpebral fissure
C0423250 BXGD008476 Corneal stromal opacities Eye Diseases
C0557874 BXGD009444 Global developmental delay
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0694550 BXGD009852 Recurrent pneumonia Infections; Respiratory Tract Diseases
C0751575 BXGD010507 Paralysis, Unilateral, Vocal Cord Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0796250 BXGD010826 PARTINGTON X-LINKED MENTAL RETARDATION SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C0870082 BXGD011309 Hyperkeratosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332943 BXGD012559 Childhood Anaplastic Oligodendroglioma Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1836047 BXGD014074 Long face
C1845050 BXGD014703 PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1845977 BXGD014769 X- linked recessive
C1854495 BXGD015410 Recurrent infection of the gastrointestinal tract
C1856121 BXGD015578 Broad eyebrow
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1862265 BXGD016119 Increased circulating gonadotropin level Nervous System Diseases; Endocrine System Diseases
C1867873 BXGD016473 Failure to thrive in infancy
C2919142 BXGD017867 Short Stature, CTCAE
C2931317 BXGD018001 Primary syphilis Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386 BXGD019284 Abnormal vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3860213 BXGD019844 Autoinflammatory disorder
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4024836 BXGD021434 Generalized reticulate brown pigmentation
C4305072 BXGD022588 X-linked intellectual disability Van Esch type Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Endocrine System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4553962 BXGD023553 Hyperkeratosis, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000061 Gallic acid 3-O-gallate 322.23
BXGC0002588 Magnesium 24.31
BXGC0002591 Potassium 39.1
BXGC0005844 Cholestanol 388.67
BXGC0038316 Cholesterol 386.35
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein