Showing entry for Atrial Septal Defects


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001235
Disease NameAtrial Septal Defects
Disease CUI IdC0018817
MeSH Codes C16   C14  
Disease Class NameCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
Semantic TypeCongenital Abnormality
Human Phenotype Ontology Id HP:0001626  
Human Phenotype Ontology TermAbnormality of the cardiovascular system
Disease Ontology Id DOID:630   DOID:7  
Disease Ontology Class Namegenetic disease; disease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00459 BXGT003924 Phosphatidylinositol 3-kinase regulatory subunit beta 5296 reviewed Enzyme modulator
O14770 BXGT004095 Homeobox protein Meis2 4212 reviewed Enzyme
O14786 BXGT004099 Neuropilin-1 8829 reviewed
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O15169 BXGT004134 Axin-1 8312 reviewed
O15550 BXGT004179 Lysine-specific demethylase 6A 7403 reviewed Epigenetic regulator
O15553 BXGT004181 Pyrin 4210 reviewed
O43175 BXGT004575 D-3-phosphoglycerate dehydrogenase 26227 reviewed Enzyme
O43683 BXGT004614 Mitotic checkpoint serine/threonine-protein kinase BUB1 699 reviewed Kinase
O43707 BXGT004616 Alpha-actinin-4 81 reviewed
O43897 BXGT004633 Tolloid-like protein 1 7092 reviewed
O60566 BXGT004884 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 701 reviewed Kinase
O75369 BXGT005119 Filamin-B 2317 reviewed
O75844 BXGT005156 CAAX prenyl protease 1 homolog 10269 reviewed Enzyme
O76039 BXGT005171 Cyclin-dependent kinase-like 5 6792 reviewed Kinase
O96028 BXGT005417 Histone-lysine N-methyltransferase NSD2 7468 reviewed Epigenetic regulator
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00734 BXGT005630 Prothrombin 2147 reviewed Enzyme
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01270 BXGT005746 Parathyroid hormone 5741 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02452 BXGT005878 Collagen alpha-1(I) chain 1277 reviewed
P02462 BXGT005881 Collagen alpha-1(IV) chain 1282 reviewed
P02545 BXGT005889 Prelamin-A/C 4000 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P05108 BXGT006317 Cholesterol side-chain cleavage enzyme, mitochondrial 1583 reviewed
P05181 BXGT006337 Cytochrome P450 2E1 1571 reviewed
P05231 BXGT006345 Interleukin-6 3569 reviewed
P08151 BXGT006731 Zinc finger protein GLI1 2735 reviewed
P08243 BXGT006755 Asparagine synthetase [glutamine-hydrolyzing] 440 reviewed Enzyme
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P08708 BXGT006817 40S ribosomal protein S17 6218 reviewed Nucleic acid binding
P09884 BXGT006937 DNA polymerase alpha catalytic subunit 5422 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P11274 BXGT007681 Breakpoint cluster region protein 613 reviewed Enzyme modulator
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P13224 BXGT007890 Platelet glycoprotein Ib beta chain 2812 reviewed
P14678 BXGT008038 Small nuclear ribonucleoprotein-associated proteins B and B' 6628 reviewed Nucleic acid binding
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15289 BXGT008102 Arylsulfatase A 410 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16157 BXGT008203 Ankyrin-1 286 reviewed
P16435 BXGT008226 NADPH--cytochrome P450 reductase 5447 reviewed
P19099 BXGT008456 Cytochrome P450 11B2, mitochondrial 1585 reviewed
P19438 BXGT008480 Tumor necrosis factor receptor superfamily member 1A 7132 reviewed
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P20248 BXGT008554 Cyclin-A2 890 reviewed Enzyme modulator
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 1131 reviewed G-protein coupled receptor
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P22033 BXGT008721 Methylmalonyl-CoA mutase, mitochondrial 4594 reviewed Enzyme
P22607 BXGT008784 Fibroblast growth factor receptor 3 2261 reviewed Kinase
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P30533 BXGT009434 Alpha-2-macroglobulin receptor-associated protein 4043 reviewed
P31939 BXGT009584 Bifunctional purine biosynthesis protein PURH 471 reviewed Enzyme
P35499 BXGT009839 Sodium channel protein type 4 subunit alpha 6329 reviewed Ion channel
P36507 BXGT009923 Dual specificity mitogen-activated protein kinase kinase 2 5605 reviewed Kinase
P36894 BXGT009939 Bone morphogenetic protein receptor type-1A 657 reviewed Kinase
P36969 BXGT009949 Phospholipid hydroperoxide glutathione peroxidase 2879 reviewed Enzyme
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P41143 BXGT010223 Delta-type opioid receptor 4985 reviewed G-protein coupled receptor
P41227 BXGT010238 N-alpha-acetyltransferase 10 8260 reviewed Enzyme
P41594 BXGT010266 Metabotropic glutamate receptor 5 2915 reviewed G-protein coupled receptor
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P47929 BXGT010598 Galectin-7 653499 reviewed Signaling
P48740 BXGT010659 Mannan-binding lectin serine protease 1 5648 reviewed Enzyme
P49585 BXGT010712 Choline-phosphate cytidylyltransferase A 5130 reviewed
P50281 BXGT010788 Matrix metalloproteinase-14 4323 reviewed Enzyme
P52732 BXGT010948 Kinesin-like protein KIF11 3832 reviewed Cellular structure
P52788 BXGT010953 Spermine synthase 6611 reviewed
P52952 BXGT010966 Homeobox protein Nkx-2.5 1482 reviewed Transcription factor
P53667 BXGT011008 LIM domain kinase 1 3984 reviewed Kinase
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P60880 BXGT011335 Synaptosomal-associated protein 25 6616 reviewed Transporter
P61978 BXGT011399 Heterogeneous nuclear ribonucleoprotein K 3190 reviewed Enzyme
P62736 BXGT011452 Actin, aortic smooth muscle 59 reviewed Cellular structure
P63165 BXGT011506 Small ubiquitin-related modifier 1 7341 reviewed
P68133 BXGT011578 Actin, alpha skeletal muscle 58 reviewed Cellular structure
P78504 BXGT011844 Protein jagged-1 182 reviewed
P98160 BXGT012228 Basement membrane-specific heparan sulfate proteoglycan core protein 3339 reviewed Enzyme modulator
Q01974 BXGT012628 Tyrosine-protein kinase transmembrane receptor ROR2 4920 reviewed Kinase
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 5604 reviewed Kinase
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q04721 BXGT012777 Neurogenic locus notch homolog protein 2 4853 reviewed
Q06124 BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 5781 reviewed
Q06609 BXGT012884 DNA repair protein RAD51 homolog 1 5888 reviewed
Q06787 BXGT012890 Synaptic functional regulator FMR1 2332 reviewed Nucleic acid binding
Q07889 BXGT012946 Son of sevenless homolog 1 6654 reviewed Enzyme modulator
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 5530 reviewed
Q09013 BXGT013023 Myotonin-protein kinase 1760 reviewed Kinase
Q09428 BXGT013036 ATP-binding cassette sub-family C member 8 6833 reviewed Transporter
Q09472 BXGT013038 Histone acetyltransferase p300 2033 reviewed
Q13043 BXGT013307 Serine/threonine-protein kinase 4 6789 reviewed Kinase
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q13586 BXGT013380 Stromal interaction molecule 1 6786 reviewed
Q13873 BXGT013398 Bone morphogenetic protein receptor type-2 659 reviewed Kinase
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C 775 reviewed Ion channel
Q14004 BXGT013435 Cyclin-dependent kinase 13 8621 reviewed Kinase
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14195 BXGT013453 Dihydropyrimidinase-related protein 3 1809 reviewed Enzyme
Q14683 BXGT013500 Structural maintenance of chromosomes protein 1A 8243 reviewed
Q14831 BXGT013506 Metabotropic glutamate receptor 7 2917 reviewed G-protein coupled receptor
Q15029 BXGT013524 116 kDa U5 small nuclear ribonucleoprotein component 9343 reviewed Enzyme
Q15652 BXGT013587 Probable JmjC domain-containing histone demethylation protein 2C 221037 reviewed
Q16678 BXGT013656 Cytochrome P450 1B1 1545 reviewed Enzyme
Q4G0J3 BXGT014809 La-related protein 7 51574 reviewed Nucleic acid binding
Q6NUK1 BXGT016429 Calcium-binding mitochondrial carrier protein SCaMC-1 29957 reviewed Transporter
Q6PCD5 BXGT016464 E3 ubiquitin-protein ligase RFWD3 55159 reviewed Enzyme
Q7Z3B3 BXGT017249 KAT8 regulatory NSL complex subunit 1 284058 reviewed
Q7Z494 BXGT017254 Nephrocystin-3 27031 reviewed
Q86YC2 BXGT017633 Partner and localizer of BRCA2 79728 reviewed
Q8IWS0 BXGT018356 PHD finger protein 6 84295 reviewed Nucleic acid binding
Q8IYD8 BXGT018367 Fanconi anemia group M protein 57697 reviewed Enzyme
Q8NFD5 BXGT018560 AT-rich interactive domain-containing protein 1B 57492 reviewed
Q8TD19 BXGT018804 Serine/threonine-protein kinase Nek9 91754 reviewed Kinase
Q8WZ42 BXGT019023 Titin 7273 reviewed Kinase
Q92793 BXGT019374 CREB-binding protein 1387 reviewed
Q92794 BXGT019375 Histone acetyltransferase KAT6A 7994 reviewed Enzyme
Q92963 BXGT019401 GTP-binding protein Rit1 6016 reviewed Enzyme modulator
Q969G3 BXGT019607 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 6605 reviewed
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha 6326 reviewed Ion channel
Q99593 BXGT019939 T-box transcription factor TBX5 6910 reviewed Transcription factor
Q99623 BXGT019941 Prohibitin-2 11331 reviewed
Q9BY08 BXGT020177 Emopamil-binding protein-like 84650 reviewed Enzyme
Q9BY41 BXGT020180 Histone deacetylase 8 55869 reviewed Epigenetic regulator
Q9H3R0 BXGT020465 Lysine-specific demethylase 4C 23081 reviewed
Q9NPD8 BXGT021152 Ubiquitin-conjugating enzyme E2 T 29089 reviewed
Q9NPI8 BXGT021161 Fanconi anemia group F protein 2188 reviewed
Q9NRF2 BXGT021185 SH2B adapter protein 1 25970 reviewed
Q9NS87 BXGT021201 Kinesin-like protein KIF15 56992 reviewed Cellular structure
Q9NW38 BXGT021230 E3 ubiquitin-protein ligase FANCL 55120 reviewed Enzyme
Q9NX14 BXGT021242 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial 54539 reviewed Enzyme
Q9UBM7 BXGT021657 7-dehydrocholesterol reductase 1717 reviewed Enzyme
Q9UGL1 BXGT021685 Lysine-specific demethylase 5B 10765 reviewed Epigenetic regulator
Q9UI95 BXGT021714 Mitotic spindle assembly checkpoint protein MAD2B 10459 reviewed
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
Q9UN88 BXGT021783 Gamma-aminobutyric acid receptor subunit theta 55879 reviewed Ion channel
Q9Y2K2 BXGT022238 Serine/threonine-protein kinase SIK3 23387 reviewed Kinase
Q9Y6K1 BXGT022331 DNA (cytosine-5)-methyltransferase 3A 1788 reviewed
Q96L73 BXGT024676 Histone-lysine N-methyltransferase, H3 lysine-36 specific 64324 reviewed Epigenetic regulator
P38646 BXGT024954 Stress-70 protein, mitochondrial 3313 reviewed
P51608 BXGT025073 Methyl-CpG-binding protein 2 4204 reviewed Epigenetic regulator
P35250 BXGT025854 Replication factor C subunit 2 5982 reviewed Enzyme
Q9UQE7 BXGT025899 Structural maintenance of chromosomes protein 3 9126 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease