Showing entry for Keratin, type I cytoskeletal 10


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007936
Protein NameKeratin, type I cytoskeletal 10
Uniport IdP13645
GeneKRT10
Gene Id3858
DomainFilament
Pfam PF00038  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0070268 cornification
Biological Process GO:0031424 keratinization
Biological Process GO:0030216 keratinocyte differentiation
Biological Process GO:0018149 peptide cross-linking
Biological Process GO:0045684 positive regulation of epidermis development
Biological Process GO:0051290 protein heterotetramerization
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0030280 structural constituent of skin epidermis
cellular component GO:0009986 cell surface
cellular component GO:0001533 cornified envelope
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005615 extracellular space
cellular component GO:0005882 intermediate filament
cellular component GO:0016020 membrane
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005859 BXGD000342 Bloom Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0006079 BXGD000365 Bowen's Disease Neoplasms
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011606 BXGD000735 Exfoliative dermatitis Skin and Connective Tissue Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011616 BXGD000739 Contact Dermatitis Skin and Connective Tissue Diseases
C0011649 BXGD000746 Dermoid Cyst Neoplasms
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0017160 BXGD001099 Gastroenteritis Digestive System Diseases
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0020758 BXGD001467 Congenital ichthyosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022596 BXGD001563 Palmoplantar Keratosis Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0023532 BXGD001685 Leukoplakia, Oral Pathological Conditions, Signs and Symptoms; Neoplasms; Stomatognathic Diseases
C0024198 BXGD001743 Lyme Disease Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034152 BXGD002467 Henoch-Schoenlein Purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0034735 BXGD002487 Raynaud Phenomenon Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0037277 BXGD002677 Skin Diseases, Genetic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0037299 BXGD002685 Skin Ulcer Skin and Connective Tissue Diseases
C0039538 BXGD002819 Teratoma Neoplasms
C0041834 BXGD002935 Erythema Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0079153 BXGD003064 Hyperkeratosis, Epidermolytic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0079298 BXGD003073 Epidermolysis Bullosa Simplex Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0079584 BXGD003083 Ichthyosis Vulgaris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0162351 BXGD003938 Contact hypersensitivity Skin and Connective Tissue Diseases
C0162810 BXGD003982 Cicatrix, Hypertrophic Pathological Conditions, Signs and Symptoms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0221228 BXGD004412 Comedone Skin and Connective Tissue Diseases
C0221270 BXGD004430 Acanthosis Pathological Conditions, Signs and Symptoms
C0232462 BXGD004542 Decrease in appetite Digestive System Diseases; Nervous System Diseases; Mental Disorders
C0237849 BXGD004849 Peeling of skin
C0265334 BXGD005520 Pachyonychia Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0265987 BXGD005598 Nevus comedonicus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C0274861 BXGD006372 Arsenic Poisoning, Inorganic Nervous System Diseases; Chemically-Induced Disorders
C0274862 BXGD006373 Nervous System, Organic Arsenic Poisoning Nervous System Diseases; Chemically-Induced Disorders
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0311375 BXGD006883 Arsenic Poisoning Nervous System Diseases; Chemically-Induced Disorders
C0334082 BXGD006987 NEVUS, EPIDERMAL (disorder) Neoplasms
C0334245 BXGD007005 Intraepithelial Squamous Cell Carcinoma Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0343731 BXGD007640 Penile warts Neoplasms; Infections; Skin and Connective Tissue Diseases; Male Urogenital Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346210 BXGD007802 Vulval intraepithelial neoplasia Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0349506 BXGD007912 Photosensitivity of skin Skin and Connective Tissue Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0432307 BXGD008771 Ichthyosis hystrix of Curth-Macklin
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677932 BXGD009736 Progressive Neoplastic Disease
C0751851 BXGD010610 Arsenic Encephalopathy Nervous System Diseases; Chemically-Induced Disorders
C0751852 BXGD010611 Arsenic Induced Polyneuropathy Nervous System Diseases; Chemically-Induced Disorders
C0846967 BXGD010865 Acanthoma Neoplasms
C0848332 BXGD010879 Spots on skin Skin and Connective Tissue Diseases
C0851140 BXGD010916 Carcinoma in situ of uterine cervix Neoplasms
C0870082 BXGD011309 Hyperkeratosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0917796 BXGD011408 Optic Atrophy, Hereditary, Leber Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1269955 BXGD012005 Tumor Cell Invasion
C1332271 BXGD012519 Perianal Squamous Intraepithelial Neoplasia
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1391732 BXGD012971 Cancer cachexia
C1561989 BXGD013368 Limbal stem cell deficiency Eye Diseases
C1836681 BXGD014147 Erythrokeratoderma, Reticular Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1843463 BXGD014584 Ichthyosis, Cyclic, with Epidermolytic Hyperkeratosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C2132198 BXGD016930 Abnormal blistering of the skin
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3539781 BXGD019086 Progressive cGVHD
C3665704 BXGD019299 Congenital reticular ichthyosiform erythroderma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C3875321 BXGD019874 Inflammatory dermatosis Skin and Connective Tissue Diseases
C4021849 BXGD020818 Conjunctival hamartoma
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4282128 BXGD022420 PATENT DUCTUS ARTERIOSUS 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4511307 BXGD023000 Keratinopathic ichthyosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002616 Copper 63.55
BXGC0002682 Zinc 65.41
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein