Showing entry for Cytoplasmic aconitate hydratase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008646
Protein NameCytoplasmic aconitate hydratase
Uniport IdP21399
GeneACO1
Gene Id48
DomainAconitase; Aconitase_C
Pfam PF00330   PF00694  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00020 Citrate cycle (TCA cycle)
1. Metabolism 1.1 Carbohydrate metabolism hsa00630 Glyoxylate and dicarboxylate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
1. Metabolism 1.0 Global and overview maps hsa01210 2-Oxocarboxylic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01230 Biosynthesis of amino acids
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006879 cellular iron ion homeostasis
Biological Process GO:0006101 citrate metabolic process
Biological Process GO:0050892 intestinal absorption
Biological Process GO:0009791 post-embryonic development
Biological Process GO:0006417 regulation of translation
Biological Process GO:0010040 response to iron(II) ion
Biological Process GO:0006099 tricarboxylic acid cycle
molecular function GO:0051538 3 iron, 4 sulfur cluster binding
molecular function GO:0051539 4 iron, 4 sulfur cluster binding
molecular function GO:0003994 aconitate hydratase activity
molecular function GO:0047780 citrate dehydratase activity
molecular function GO:0030350 iron-responsive element binding
molecular function GO:0046872 metal ion binding
molecular function GO:0003723 RNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0070062 extracellular exosome
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-382551 Transport of small molecules
R-HSA-917937 Iron uptake and transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0010474 BXGD000672 Curling Ulcer Digestive System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013295 BXGD000812 Duodenal Ulcer Digestive System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0018995 BXGD001265 Hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0027626 BXGD002005 Neoplasm Invasiveness Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0032461 BXGD002356 Polycythemia Hemic and Lymphatic Diseases
C0032463 BXGD002357 Polycythemia Vera Neoplasms; Hemic and Lymphatic Diseases
C0032969 BXGD002385 Pregnancy in Diabetics Female Urogenital Diseases and Pregnancy Complications
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0040558 BXGD002873 Toxoplasmosis Infections
C0085576 BXGD003188 Iron-Refractory Iron Deficiency Anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0086743 BXGD003308 Osteoarthrosis Deformans Musculoskeletal Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0162316 BXGD003936 Iron deficiency anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238644 BXGD004949 Anemia, severe Hemic and Lymphatic Diseases
C0240066 BXGD005016 Iron deficiency Nutritional and Metabolic Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0282193 BXGD006798 Iron Overload Nutritional and Metabolic Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392514 BXGD008051 Hereditary hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0403592 BXGD008297 Chronic rejection of renal transplant Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1318533 BXGD012398 Secondary polycythemia Neoplasms; Hemic and Lymphatic Diseases
C1395512 BXGD012989 Placental dysfunction
C1833213 BXGD013900 Hyperferritinemia, hereditary, with congenital cataracts Nutritional and Metabolic Diseases; Eye Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2750440 BXGD017660 FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1
C2750441 BXGD017661 LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
C3150651 BXGD018316 FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4529962 BXGD023178 Fatty Liver Disease
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4749274 BXGD024052 Chuvash erythrocytosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0006368 Formic acid 46.03
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein