Showing entry for COUP transcription factor 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008969
Protein NameCOUP transcription factor 2
Uniport IdP24468
GeneNR2F2
Gene Id7026
DomainHormone_recep; zf-C4
Pfam PF00104   PF00105  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0048856 anatomical structure development
Biological Process GO:0009952 anterior/posterior pattern specification
Biological Process GO:0048514 blood vessel morphogenesis
Biological Process GO:0030154 cell differentiation
Biological Process GO:0009566 fertilization
Biological Process GO:0030900 forebrain development
Biological Process GO:0060173 limb development
Biological Process GO:0001893 maternal placenta development
Biological Process GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process GO:0010596 negative regulation of endothelial cell migration
Biological Process GO:0001937 negative regulation of endothelial cell proliferation
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0001764 neuron migration
Biological Process GO:0060674 placenta blood vessel development
Biological Process GO:0003084 positive regulation of systemic arterial blood pressure
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0009956 radial pattern formation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment
Biological Process GO:0032355 response to estradiol
Biological Process GO:0007519 skeletal muscle tissue development
Biological Process GO:0060707 trophoblast giant cell differentiation
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0004879 nuclear receptor activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0001972 retinoic acid binding
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002962 BXGD000160 Angina Pectoris Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003492 BXGD000198 Aortic coarctation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0003507 BXGD000203 Aortic Valve Stenosis Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004239 BXGD000263 Atrial Flutter Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0013069 BXGD000796 Double Outlet Right Ventricle Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0014121 BXGD000895 Bacterial Endocarditis Infections; Cardiovascular Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018808 BXGD001229 Heart murmur Pathological Conditions, Signs and Symptoms
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0019284 BXGD001312 Diaphragmatic Hernia Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021361 BXGD001499 Female infertility Female Urogenital Diseases and Pregnancy Complications
C0021933 BXGD001524 Intussusception Digestive System Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0026266 BXGD001895 Mitral Valve Insufficiency Cardiovascular Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030252 BXGD002199 Palpitations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0035869 BXGD002569 Rotavirus Infections Infections
C0038279 BXGD002744 Sterility, Postpartum Female Urogenital Diseases and Pregnancy Complications
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039685 BXGD002825 Tetralogy of Fallot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0078918 BXGD003055 Albinism, Oculocutaneous Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0149630 BXGD003334 Bicuspid aortic valve Cardiovascular Diseases
C0152101 BXGD003540 Hypoplastic Left Heart Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220766 BXGD004341 Congenital hypoplasia of adrenal gland Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Endocrine System Diseases
C0231807 BXGD004524 Dyspnea on exertion Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0265783 BXGD005575 Congenital hypoplasia of lung Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0266642 BXGD005705 Situs ambiguus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0266929 BXGD005722 Chronic Periodontitis Stomatognathic Diseases
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0334037 BXGD006980 Intestinal metaplasia
C0341869 BXGD007427 Subfertility, Female Female Urogenital Diseases and Pregnancy Complications
C0342276 BXGD007449 Maturity onset diabetes mellitus in young Nutritional and Metabolic Diseases; Endocrine System Diseases
C0342482 BXGD007486 X-linked Adrenal Hypoplasia Endocrine System Diseases
C0344735 BXGD007702 Partial atrioventricular canal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392482 BXGD008048 Common atrium Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0741916 BXGD010044 Cardiac defects
C0752123 BXGD010671 Spinocerebellar Ataxia Type 5 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0917730 BXGD011406 Female sterility Female Urogenital Diseases and Pregnancy Complications
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1389016 BXGD012962 ATRIOVENTRICULAR CANAL DEFECT Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1848873 BXGD014981 Abnormality of the diaphragm
C1852093 BXGD015258 Maturity-Onset Diabetes of the Young, Type 1 Nutritional and Metabolic Diseases; Endocrine System Diseases
C1855580 BXGD015515 Exercise-induced muscle fatigue
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3160712 BXGD018467 Palpitations, CTCAE
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C4014310 BXGD020140 CONGENITAL HEART DEFECTS, MULTIPLE TYPES, 4
C4021866 BXGD020823 obsolete Abnormal heart morphology
C4023290 BXGD021152 Partial defect of atrioventricular canal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4025753 BXGD021777 Abnormal tricuspid valve morphology
C4049796 BXGD021951 Abnormality of cardiovascular system morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4330050 BXGD022798 WHO Grade II Glioma
C4531220 BXGD023207 Coronary sinus enlargement
C4551905 BXGD023438 Pulmonary Venous Return Anomaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Cardiovascular Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0031457 ACTIPHENOL 275.12
BXGC0033776 Cycloheximide 281.16
BXGC0047086 4-[(2R)-2-[(1R,3R,5S)-3,5-Dimethyl-2-Oxocyclohexyl]-2-Hydroxyethyl]Piperidine-2,6-Dione 281.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein