Showing entry for Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009409
Protein NameSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Uniport IdP30153
GenePPP2R1A
Gene Id5518
DomainHEAT
Pfam PF02985  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa03015 mRNA surveillance pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04071 Sphingolipid signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04114 Oocyte meiosis
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04152 AMPK signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
3. Environmental Information Processing 3.2 Signal transduction hsa04350 TGF-beta signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
5. Organismal Systems 5.6 Nervous system hsa04730 Long-term depression
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05142 Chagas disease (American trypanosomiasis)
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0006672 ceramide metabolic process
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0097711 ciliary basal body-plasma membrane docking
Biological Process GO:0007143 female meiotic nuclear division
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:0000188 inactivation of MAPK activity
Biological Process GO:0051754 meiotic sister chromatid cohesion, centromeric
Biological Process GO:0051232 meiotic spindle elongation
Biological Process GO:0007084 mitotic nuclear envelope reassembly
Biological Process GO:0051306 mitotic sister chromatid separation
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
Biological Process GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Process GO:0070262 peptidyl-serine dephosphorylation
Biological Process GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:0045595 regulation of cell differentiation
Biological Process GO:0006275 regulation of DNA replication
Biological Process GO:0010389 regulation of G2/M transition of mitotic cell cycle
Biological Process GO:0040008 regulation of growth
Biological Process GO:1903538 regulation of meiotic cell cycle process involved in oocyte maturation
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0030111 regulation of Wnt signaling pathway
Biological Process GO:0010033 response to organic substance
Biological Process GO:0008380 RNA splicing
Biological Process GO:0019932 second-messenger-mediated signaling
molecular function GO:1990405 protein antigen binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0019888 protein phosphatase regulator activity
molecular function GO:0004722 protein serine/threonine phosphatase activity
cellular component GO:0000775 chromosome, centromeric region
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0070062 extracellular exosome
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0016328 lateral plasma membrane
cellular component GO:0016020 membrane
cellular component GO:0015630 microtubule cytoskeleton
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
cellular component GO:0000159 protein phosphatase type 2A complex
cellular component GO:0008287 protein serine/threonine phosphatase complex
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-111885 Opioid Signalling
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-HSA-113510 E2F mediated regulation of DNA replication
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-1295596 Spry regulation of FGF signaling
R-HSA-141424 Amplification of signal from the kinetochores
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-163685 Integration of energy metabolism
R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors
R-HSA-1640170 Cell Cycle
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-166520 Signaling by NTRKs
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-180024 DARPP-32 events
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-190236 Signaling by FGFR
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-195258 RHO GTPase Effectors
R-HSA-195721 Signaling by WNT
R-HSA-195721 Signaling by WNT
R-HSA-196299 Beta-catenin phosphorylation cascade
R-HSA-198725 Nuclear Events (kinase and transcription factor activation)
R-HSA-198753 ERK/MAPK targets
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-202670 ERKs are inactivated
R-HSA-212436 Generic Transcription Pathway
R-HSA-2465910 MASTL Facilitates Mitotic Progression
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation
R-HSA-2995410 Nuclear Envelope (NE) Reassembly
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-372790 Signaling by GPCR
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380287 Centrosome maturation
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-388396 GPCR downstream signalling
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389513 CTLA4 inhibitory signaling
R-HSA-418346 Platelet homeostasis
R-HSA-418594 G alpha (i) signalling events
R-HSA-432142 Platelet sensitization by LDL
R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-450294 MAP kinase activation
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-4791275 Signaling by WNT in cancer
R-HSA-4839735 AXIN mutants destabilize the destruction complex, activating WNT signaling
R-HSA-4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
R-HSA-4839744 truncated APC mutants destabilize the destruction complex
R-HSA-4839748 AMER1 mutants destabilize the destruction complex
R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated
R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated
R-HSA-5467337 APC truncation mutants have impaired AXIN binding
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex
R-HSA-5617833 Cilium Assembly
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654741 Signaling by FGFR3
R-HSA-5654743 Signaling by FGFR4
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-5673000 RAF activation
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-68875 Mitotic Prophase
R-HSA-68877 Mitotic Prometaphase
R-HSA-68882 Mitotic Anaphase
R-HSA-68886 M Phase
R-HSA-68886 M Phase
R-HSA-69206 G1/S Transition
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69236 G1 Phase
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69275 G2/M Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69618 Mitotic Spindle Checkpoint
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-70171 Glycolysis
R-HSA-70326 Glucose metabolism
R-HSA-71387 Metabolism of carbohydrates
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8854518 AURKA Activation by TPX2
R-HSA-8953854 Metabolism of RNA
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-927802 Nonsense-Mediated Decay (NMD)
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-9607240 FLT3 Signaling
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0007130 BXGD000440 Mucinous Adenocarcinoma Neoplasms
C0007140 BXGD000447 Carcinosarcoma Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0016842 BXGD001083 Congenital pectus excavatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0086743 BXGD003308 Osteoarthrosis Deformans Musculoskeletal Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153567 BXGD003665 Uterine Cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0153574 BXGD003667 Malignant Uterine Corpus Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0156344 BXGD003851 Endometriosis of ovary Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205698 BXGD004109 Undifferentiated carcinoma Neoplasms
C0206687 BXGD004242 Carcinoma, Endometrioid Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0206701 BXGD004251 Cystadenocarcinoma, Serous Neoplasms
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235874 BXGD004781 Disease Exacerbation Pathological Conditions, Signs and Symptoms
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0239234 BXGD004974 Low set ears
C0240379 BXGD005033 Open mouth (finding)
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0265529 BXGD005542 Plagiocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0279663 BXGD006676 Serous cystadenocarcinoma ovary Neoplasms
C0280630 BXGD006751 Uterine Carcinosarcoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0346163 BXGD007785 Endometrioid carcinoma ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0346957 BXGD007836 Disseminated Malignant Neoplasm Neoplasms
C0423110 BXGD008471 Downward slant of palpebral fissure
C0424503 BXGD008532 Dysmorphic facies
C0431447 BXGD008690 Synophrys Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677779 BXGD009729 hereditary Wilms tumor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0854924 BXGD011052 Papillary serous endometrial carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0855329 BXGD011084 Electrocardiogram change
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306710 BXGD012372 Facial asymmetry Pathological Conditions, Signs and Symptoms
C1332629 BXGD012540 Breast Fibrocystic Change, Proliferative Type Skin and Connective Tissue Diseases
C1333015 BXGD012581 Childhood Kidney Wilms Tumor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C1837658 BXGD014257 Gross motor development delay Mental Disorders
C1839767 BXGD014404 Tented upper lip vermilion
C1840077 BXGD014434 Anteverted nostril
C1845251 BXGD014734 Facial hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1856888 BXGD015651 Clinodactyly of the thumb
C1857949 BXGD015758 Prominent metopic ridge
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1867131 BXGD016440 Broad hallux
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2243051 BXGD017008 Large head (disorder)
C2936786 BXGD018137 Aqueductal Stenosis Nervous System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3278923 BXGD018748 Dilated ventricles (finding)
C3280303 BXGD018820 Abnormal hair whorl
C3544205 BXGD019109 Ovarian clear cell carcinoma
C3553450 BXGD019175 Profound global developmental delay
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3839280 BXGD019772 High grade serous carcinoma
C4021515 BXGD020648 Deviation of the 5th finger
C4021798 BXGD020788 Impaired use of nonverbal behaviors Mental Disorders
C4025863 BXGD021834 Abnormality of the orbital region
C4225352 BXGD022234 MENTAL RETARDATION, AUTOSOMAL DOMINANT 36
C4551563 BXGD023351 Microcephaly (physical finding)
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0014624 Propane 44.06
BXGC0038991 Selenomethionine 197
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein