Showing entry for Childhood Kidney Wilms Tumor


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD012581
Disease NameChildhood Kidney Wilms Tumor
Disease CUI IdC1333015
MeSH Codes C16   C04   C13   C12  
Disease Class NameCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O15350 BXGT004154 Tumor protein p73 7161 reviewed Transcription factor
O15527 BXGT004176 N-glycosylase/DNA lyase 4968 reviewed
O43707 BXGT004616 Alpha-actinin-4 81 reviewed
O60566 BXGT004884 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 701 reviewed Kinase
O75084 BXGT005098 Frizzled-7 8324 reviewed G-protein coupled receptor
O75151 BXGT005103 Lysine-specific demethylase PHF2 5253 reviewed
O75365 BXGT005115 Protein tyrosine phosphatase type IVA 3 11156 reviewed
O94907 BXGT005340 Dickkopf-related protein 1 22943 reviewed
P00352 BXGT005510 Retinal dehydrogenase 1 216 reviewed Enzyme
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01270 BXGT005746 Parathyroid hormone 5741 reviewed
P01308 BXGT005749 Insulin 3630 reviewed
P01909 BXGT005815 HLA class II histocompatibility antigen, DQ alpha 1 chain 3117 reviewed Immune response
P02775 BXGT005960 Platelet basic protein 5473 reviewed Signaling
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04406 BXGT006207 Glyceraldehyde-3-phosphate dehydrogenase 2597 reviewed Enzyme
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06213 BXGT006425 Insulin receptor 3643 reviewed Kinase
P06748 BXGT006497 Nucleophosmin 4869 reviewed Chaperone
P07101 BXGT006547 Tyrosine 3-monooxygenase 7054 reviewed
P07737 BXGT006663 Profilin-1 5216 reviewed
P07949 BXGT006703 Proto-oncogene tyrosine-protein kinase receptor Ret 5979 reviewed Kinase
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08138 BXGT006729 Tumor necrosis factor receptor superfamily member 16 4804 reviewed Receptor
P08151 BXGT006731 Zinc finger protein GLI1 2735 reviewed
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C 5788 reviewed Enzyme
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08670 BXGT006810 Vimentin 7431 reviewed
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10276 BXGT007553 Retinoic acid receptor alpha 5914 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P11274 BXGT007681 Breakpoint cluster region protein 613 reviewed Enzyme modulator
P11388 BXGT007697 DNA topoisomerase 2-alpha 7153 reviewed
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P11717 BXGT007740 Cation-independent mannose-6-phosphate receptor 3482 reviewed Receptor
P11802 BXGT007750 Cyclin-dependent kinase 4 1019 reviewed Kinase
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P12830 BXGT007852 Cadherin-1 999 reviewed
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14866 BXGT008060 Heterogeneous nuclear ribonucleoprotein L 3191 reviewed
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P17252 BXGT008294 Protein kinase C alpha type 5578 reviewed Kinase
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P18075 BXGT008375 Bone morphogenetic protein 7 655 reviewed Signaling
P18146 BXGT008384 Early growth response protein 1 1958 reviewed Nucleic acid binding
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P22897 BXGT008816 Macrophage mannose receptor 1 4360 reviewed
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P23921 BXGT008927 Ribonucleoside-diphosphate reductase large subunit 6240 reviewed Enzyme
P24158 BXGT008951 Myeloblastin 5657 reviewed Enzyme
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P25791 BXGT009072 Rhombotin-2 4005 reviewed
P26447 BXGT009114 Protein S100-A4 6275 reviewed Calcium-binding protein
P27169 BXGT009161 Serum paraoxonase/arylesterase 1 5444 reviewed
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P27635 BXGT009194 60S ribosomal protein L10 6134 reviewed Nucleic acid binding
P27986 BXGT009216 Phosphatidylinositol 3-kinase regulatory subunit alpha 5295 reviewed Kinase
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 952 reviewed Enzyme
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29373 BXGT009337 Cellular retinoic acid-binding protein 2 1382 reviewed
P30153 BXGT009409 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 5518 reviewed Enzyme
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P32418 BXGT009635 Sodium/calcium exchanger 1 6546 reviewed Transporter
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35221 BXGT009798 Catenin alpha-1 1495 reviewed Cellular structure
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P36888 BXGT009938 Receptor-type tyrosine-protein kinase FLT3 2322 reviewed Kinase
P36894 BXGT009939 Bone morphogenetic protein receptor type-1A 657 reviewed Kinase
P36955 BXGT009946 Pigment epithelium-derived factor 5176 reviewed Enzyme modulator
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P39748 BXGT010134 Flap endonuclease 1 2237 reviewed Enzyme
P40337 BXGT010174 von Hippel-Lindau disease tumor suppressor 7428 reviewed Enzyme
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P40967 BXGT010212 Melanocyte protein PMEL 6490 reviewed Signaling
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42330 BXGT010301 Aldo-keto reductase family 1 member C3 8644 reviewed Enzyme
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P48023 BXGT010604 Tumor necrosis factor ligand superfamily member 6 356 reviewed Signaling
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49711 BXGT010728 Transcriptional repressor CTCF 10664 reviewed Transcription factor
P50120 BXGT010773 Retinol-binding protein 2 5948 reviewed
P51114 BXGT010832 Fragile X mental retardation syndrome-related protein 1 8087 reviewed Nucleic acid binding
P51787 BXGT010889 Potassium voltage-gated channel subfamily KQT member 1 3784 reviewed Ion channel
P51843 BXGT010897 Nuclear receptor subfamily 0 group B member 1 190 reviewed Nuclear receptor
P52701 BXGT010943 DNA mismatch repair protein Msh6 2956 reviewed Nucleic acid binding
P54278 BXGT011038 Mismatch repair endonuclease PMS2 5395 reviewed Nucleic acid binding
P55157 BXGT011108 Microsomal triglyceride transfer protein large subunit 4547 reviewed Transporter
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P62834 BXGT011464 Ras-related protein Rap-1A 5906 reviewed Enzyme modulator
P68871 BXGT011615 Hemoglobin subunit beta 3043 reviewed
P78504 BXGT011844 Protein jagged-1 182 reviewed
Q01105 BXGT012569 Protein SET 6418 reviewed Enzyme modulator
Q01196 BXGT012575 Runt-related transcription factor 1 861 reviewed Transcription factor
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q06710 BXGT012887 Paired box protein Pax-8 7849 reviewed
Q07955 BXGT012951 Serine/arginine-rich splicing factor 1 6426 reviewed Nucleic acid binding
Q13285 BXGT013335 Steroidogenic factor 1 2516 reviewed Nuclear receptor
Q13467 BXGT013358 Frizzled-5 7855 reviewed G-protein coupled receptor
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q13586 BXGT013380 Stromal interaction molecule 1 6786 reviewed
Q13671 BXGT013391 Ras and Rab interactor 1 9610 reviewed Enzyme modulator
Q14457 BXGT013472 Beclin-1 8678 reviewed Enzyme modulator
Q15257 BXGT013554 Serine/threonine-protein phosphatase 2A activator 5524 reviewed Enzyme modulator
Q15274 BXGT013556 Nicotinate-nucleotide pyrophosphorylase [carboxylating] 23475 reviewed
Q15554 BXGT013577 Telomeric repeat-binding factor 2 7014 reviewed
Q15796 BXGT013599 Mothers against decapentaplegic homolog 2 4087 reviewed Transcription factor
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 6794 reviewed Kinase
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16548 BXGT013636 Bcl-2-related protein A1 597 reviewed Signaling
Q16576 BXGT013641 Histone-binding protein RBBP7 5931 reviewed
Q16674 BXGT013655 Melanoma-derived growth regulatory protein 8190 reviewed
Q6ZN17 BXGT016631 Protein lin-28 homolog B 389421 reviewed
Q92979 BXGT019402 Ribosomal RNA small subunit methyltransferase NEP1 10436 reviewed Nucleic acid binding
Q96SB4 BXGT019740 SRSF protein kinase 1 6732 reviewed Kinase
Q99816 BXGT019966 Tumor susceptibility gene 101 protein 7251 reviewed Enzyme
Q9BUB5 BXGT020133 MAP kinase-interacting serine/threonine-protein kinase 1 8569 reviewed Kinase
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UPY3 BXGT021802 Endoribonuclease Dicer 23405 reviewed Enzyme
Q9UQL6 BXGT021813 Histone deacetylase 5 10014 reviewed Epigenetic regulator
Q9Y4P1 BXGT022283 Cysteine protease ATG4B 23192 reviewed Enzyme
Q96QD8 BXGT022647 Sodium-coupled neutral amino acid transporter 2 54407 reviewed Transporter
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
P35232 BXGT022663 Prohibitin 5245 reviewed
Q13029 BXGT022688 PR domain zinc finger protein 2 7799 reviewed
P35240 BXGT022927 Merlin 4771 reviewed
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
Q01543 BXGT023137 Friend leukemia integration 1 transcription factor 2313 reviewed Transcription factor
Q13635 BXGT024910 Protein patched homolog 1 5727 reviewed
Q9NRR4 BXGT025788 Ribonuclease 3 29102 reviewed Enzyme
P21731 BXGT026174 Thromboxane A2 receptor 6915 reviewed G-protein coupled receptor
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease