Showing entry for ATP-sensitive inward rectifier potassium channel 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010610
Protein NameATP-sensitive inward rectifier potassium channel 1
Uniport IdP48048
GeneKCNJ1
Gene Id3758
DomainIRK; IRK_C
Pfam PF01007   PF17655  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.5 Excretory system hsa04960 Aldosterone-regulated sodium reabsorption
5. Organismal Systems 5.4 Digestive system hsa04971 Gastric acid secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007588 excretion
Biological Process GO:1990573 potassium ion import across plasma membrane
Biological Process GO:0006813 potassium ion transport
Biological Process GO:0034765 regulation of ion transmembrane transport
molecular function GO:0015272 ATP-activated inward rectifier potassium channel activity
molecular function GO:0005524 ATP binding
molecular function GO:0005242 inward rectifier potassium channel activity
molecular function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
cellular component GO:0005886 plasma membrane
cellular component GO:0008076 voltage-gated potassium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-1296065 Inwardly rectifying K+ channels
R-HSA-1296067 Potassium transport channels
R-HSA-1296071 Potassium Channels
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0002452 BXGD000116 Amelogenesis Imperfecta Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004775 BXGD000290 Bartter Disease Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0020224 BXGD001366 Polyhydramnios Female Urogenital Diseases and Pregnancy Complications
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020428 BXGD001377 Hyperaldosteronism Endocrine System Diseases
C0020438 BXGD001382 Hypercalciuria Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020599 BXGD001441 Hypocalciuria Nutritional and Metabolic Diseases
C0020621 BXGD001449 Hypokalemia Nutritional and Metabolic Diseases
C0020625 BXGD001451 Hyponatremia Nutritional and Metabolic Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027709 BXGD002026 Nephrocalcinosis Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030554 BXGD002239 Paresthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0032617 BXGD002367 Polyuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0033805 BXGD002427 Pseudohypoaldosteronism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039621 BXGD002824 Tetany Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Nervous System Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085570 BXGD003186 Hypokalemic alkalosis Nutritional and Metabolic Diseases
C0085602 BXGD003199 Polydipsia Pathological Conditions, Signs and Symptoms
C0085680 BXGD003236 Hypochloremia (disorder) Nutritional and Metabolic Diseases
C0151526 BXGD003432 Premature Birth Female Urogenital Diseases and Pregnancy Complications
C0152421 BXGD003586 Macrotia
C0220666 BXGD004316 ARTHROGRYPOSIS MULTIPLEX CONGENITA, DISTAL, TYPE IIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0232831 BXGD004564 Impairment of urinary concentration Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0235991 BXGD004802 Small for gestational age (disorder) Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0240783 BXGD005054 Increased circulating renin level
C0268450 BXGD005951 Gitelman Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0268855 BXGD006046 Hypertrophy of bladder Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0302511 BXGD006849 Small for gestational age fetus Pathological Conditions, Signs and Symptoms
C0342276 BXGD007449 Maturity onset diabetes mellitus in young Nutritional and Metabolic Diseases; Endocrine System Diseases
C0348460 BXGD007873 Other hyperaldosteronism Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0428908 BXGD008641 Sinus Node Dysfunction (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0523465 BXGD009209 Serum albumin measurement
C0553730 BXGD009417 Calcium pyrophosphate deposition disease Musculoskeletal Diseases
C0557874 BXGD009444 Global developmental delay
C0595901 BXGD009624 Serum chloride level decreased (finding) Nutritional and Metabolic Diseases
C0740898 BXGD010014 Hypokalemic metabolic alkalosis
C0746674 BXGD010147 Generalized muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1449844 BXGD013095 Pseudohypoaldosteronism, Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1835884 BXGD014061 Triangular face
C1837260 BXGD014214 Prominent forehead
C1846343 BXGD014799 Bartter syndrome, type 3 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1846345 BXGD014801 Hyperactive renin-angiotensin system
C1846347 BXGD014802 Renal salt wasting
C1846348 BXGD014803 Renal potassium wasting
C1846351 BXGD014804 Increased urinary potassium
C1846352 BXGD014805 Hyperchloriduria
C1855849 BXGD015553 Bartter syndrome, antenatal , type 2 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1855852 BXGD015554 Abnormally large globe
C1855853 BXGD015555 Impaired platelet aggregation
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1859040 BXGD015844 Medullary Cystic Kidney Disease Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1865279 BXGD016303 Fetal polyuria
C1866495 BXGD016402 Bartter syndrome, antenatal type 1 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1866496 BXGD016403 Renal juxtaglomerular cell hypertrophy/hyperplasia
C1866498 BXGD016404 Hyperprostaglandinuria
C1866500 BXGD016405 Low-to-normal blood pressure Cardiovascular Diseases
C1960636 BXGD016668 Dysglycemia
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C3150358 BXGD018303 Increased serum prostaglandin E2
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887638 BXGD019906 Failure to thrive in infant Pathological Conditions, Signs and Symptoms
C4020705 BXGD020471 Glomerulocystic kidney disease
C4525496 BXGD023137 Hamster Insulinoma
C4551496 BXGD023320 Hyperuricemic Nephropathy, Familial Juvenile 1 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases
C4552811 BXGD023526 Generalized Muscle Weakness, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004285 Agmatine 130.19
BXGC0042519 Glimepiride 490.22
BXGC0046755 Yohimbine 354.19
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein