Showing entry for Yohimbine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0046755
Compound NameYohimbine
Structure
FormulaC21H26N2O3
InchiKeyBLGXFZZNTVWLAY-SCYLSFHTSA-N
SMILESCOC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1
InchiInChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
IUPACmethyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
Molecular Weight354.19
Pubchem Id8969
Chembl IdCHEMBL15245
Targets of Information Source
DrugBank DB01392
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A approved; investigational; vet_approved antagonist
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B approved; investigational; vet_approved antagonist
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C approved; investigational; vet_approved antagonist
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A approved; investigational; vet_approved partial agonist
P28222 BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B approved; investigational; vet_approved antagonist
P28221 BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D approved; investigational; vet_approved antagonist
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 approved; investigational; vet_approved antagonist
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 approved; investigational; vet_approved antagonist
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A approved; investigational; vet_approved antagonist
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C approved; investigational; vet_approved antagonist
P48048 BXGT010610 ATP-sensitive inward rectifier potassium channel 1 reviewed Ion channel KCNJ1 approved; investigational; vet_approved -
P78508 BXGT011845 ATP-sensitive inward rectifier potassium channel 10 reviewed Ion channel KCNJ10 approved; investigational; vet_approved -
Q14654 BXGT013495 ATP-sensitive inward rectifier potassium channel 11 reviewed Ion channel KCNJ11 approved; investigational; vet_approved -
Q14500 BXGT013477 ATP-sensitive inward rectifier potassium channel 12 reviewed Ion channel KCNJ12 approved; investigational; vet_approved -
Q9UNX9 BXGT021794 ATP-sensitive inward rectifier potassium channel 14 reviewed - KCNJ14 approved; investigational; vet_approved -
Q99712 BXGT019953 ATP-sensitive inward rectifier potassium channel 15 reviewed Ion channel KCNJ15 approved; investigational; vet_approved -
Q15842 BXGT013607 ATP-sensitive inward rectifier potassium channel 8 reviewed Ion channel KCNJ8 approved; investigational; vet_approved inhibitor
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B approved; investigational; vet_approved antagonist
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50013515
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT022194 Zinc finger protein mex-5 reviewed mex-5 - - - 103486
reviewed BXGT010925 Importin subunit alpha-1 reviewed Transporter KPNA2 - - - >500000
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 150 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 480 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 1000 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B 5 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 0.32 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 0.44 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 0.5 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 0.65 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 0.37 - - -
reviewed BXGT008473 Alpha-2B adrenergic receptor reviewed Adra2b 0.45 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 1.18 - - -
reviewed BXGT008473 Alpha-2B adrenergic receptor reviewed Adra2b 1 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 0.13 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 0.3 - - -
reviewed BXGT009486 5-hydroxytryptamine receptor 5A reviewed Htr5a 1000 - - -
reviewed BXGT009274 5-hydroxytryptamine receptor 1E reviewed G-protein coupled receptor HTR1E 3434 - - -
reviewed BXGT009274 5-hydroxytryptamine receptor 1E reviewed G-protein coupled receptor HTR1E 1270 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B 16 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B 22 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 40 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 27 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 59 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 51 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 132 - - -
reviewed BXGT008473 Alpha-2B adrenergic receptor reviewed Adra2b 100 - - -
reviewed BXGT009827 Alpha-2C adrenergic receptor reviewed ADRA2C 20 - - -
reviewed BXGT009827 Alpha-2C adrenergic receptor reviewed ADRA2C 0.08 - - -
reviewed BXGT009827 Alpha-2C adrenergic receptor reviewed ADRA2C 0.4 - - -
reviewed BXGT008160 Alpha-1B adrenergic receptor reviewed Adra1b 517 - - -
reviewed BXGT008382 Alpha-1A adrenergic receptor reviewed ADRA1A 142 - - -
reviewed BXGT009272 5-hydroxytryptamine receptor 1B reviewed Htr1b 8700 - - -
reviewed BXGT009272 5-hydroxytryptamine receptor 1B reviewed Htr1b 7540 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A 4500 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 77 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 0.32 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 1.2 - - -
reviewed BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Cacna1c 1000 - - -
reviewed BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Cacna1c >10000 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 562 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 263 - - -
reviewed BXGT003959 Alpha-1A adrenergic receptor reviewed ADRA1A 1100 - - -
reviewed BXGT003959 Alpha-1A adrenergic receptor reviewed ADRA1A 275 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 17 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 6 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 19 - - -
reviewed BXGT005197 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 21 - - -
reviewed BXGT015983 Alpha-2A adrenergic receptor reviewed ADRA2A 6 - - -
reviewed BXGT015983 Alpha-2A adrenergic receptor reviewed ADRA2A 15 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 10 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 13 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 0.83 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 0.72 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 2271 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 14.3 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 1.2 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 64 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 36 - - -
reviewed BXGT005194 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 28 - - -
reviewed BXGT005194 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 0.04 - - -
reviewed BXGT005194 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 0.18 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 158 - - -
reviewed BXGT021402 Sigma non-opioid intracellular receptor 1 reviewed Sigmar1 >10000 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 236 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 230 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 7857 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 43 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 40 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 2.7 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 1.6 - - -
reviewed BXGT008472 5-hydroxytryptamine receptor 1A reviewed Htr1a 1318.26 - - -
reviewed BXGT008472 5-hydroxytryptamine receptor 1A reviewed Htr1a 1548.82 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A >10000 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 1000 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a >10000 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 398.1 - - -
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b 50.11 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C >10000 - - -
reviewed BXGT006838 5-hydroxytryptamine receptor 2C reviewed Htr2c >10000 - - -
reviewed BXGT009819 5-hydroxytryptamine receptor 5A reviewed Htr5a 1000 - - -
reviewed BXGT009820 5-hydroxytryptamine receptor 5B reviewed Htr5b 1000 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 1100 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 320 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 120 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 18 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 200 - - -
reviewed BXGT008428 Alpha-1B adrenergic receptor reviewed ADRA1B 670 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 3.6 - - -
reviewed BXGT006838 5-hydroxytryptamine receptor 2C reviewed Htr2c 5011.87 - - -
reviewed BXGT008434 Alpha-2A adrenergic receptor reviewed ADRA2A 0.26 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 0.43 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 0.44 - - -
reviewed BXGT013955 Alpha-2A adrenergic receptor reviewed ADRA2A 3.38 - - -
reviewed BXGT005194 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 0.11 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 0.61 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 0.56 - - -
reviewed BXGT013955 Alpha-2A adrenergic receptor reviewed ADRA2A 9.77 - - -
reviewed BXGT005194 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 0.19 - - -
reviewed BXGT008434 Alpha-2A adrenergic receptor reviewed ADRA2A 0.37 - - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 19 - - -
reviewed BXGT013955 Alpha-2A adrenergic receptor reviewed ADRA2A 9.5 - - -
reviewed BXGT009272 5-hydroxytryptamine receptor 1B reviewed Htr1b 6309.57 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B 39.81 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B 46.77 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B 251.18 - - -
reviewed BXGT009272 5-hydroxytryptamine receptor 1B reviewed Htr1b 4466.83 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B 26.91 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B 40.73 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B 5.01 - - -
reviewed BXGT009254 5-hydroxytryptamine receptor 1B reviewed Htr1b >10000 - - -
reviewed BXGT009272 5-hydroxytryptamine receptor 1B reviewed Htr1b 151.35 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 15.84 - - -
reviewed BXGT007730 5-hydroxytryptamine receptor 1D reviewed HTR1D 5.24 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 58.88 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 47.86 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 21.87 - - -
reviewed BXGT009273 5-hydroxytryptamine receptor 1D reviewed Htr1d 30.9 - - -
reviewed BXGT007730 5-hydroxytryptamine receptor 1D reviewed HTR1D 32.35 - - -
reviewed BXGT009274 5-hydroxytryptamine receptor 1E reviewed G-protein coupled receptor HTR1E 1258.92 - - -
reviewed BXGT012647 5-hydroxytryptamine receptor 1F reviewed Htr1f 63.09 - - -
reviewed BXGT009484 5-hydroxytryptamine receptor 1F reviewed Htr1f 562.34 - - -
reviewed BXGT009483 5-hydroxytryptamine receptor 1F reviewed G-protein coupled receptor HTR1F 91.2 - - -
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b 58.88 - - -
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b 35.48 - - -
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b 107.15 - - -
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b 53.7 - - -
reviewed BXGT009486 5-hydroxytryptamine receptor 5A reviewed Htr5a 630.95 - - -
reviewed BXGT009531 5-hydroxytryptamine receptor 5B reviewed Htr5b 1000 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 3.76 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 3.71 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 4.59 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 13.6 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 0.78 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 3.02 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 40.6 - - -
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b 53.1 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A 1500 - - -
reviewed BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 2850 - - -
reviewed BXGT009483 5-hydroxytryptamine receptor 1F reviewed G-protein coupled receptor HTR1F 92 - - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A 770 - - -
reviewed BXGT009486 5-hydroxytryptamine receptor 5A reviewed Htr5a >10000 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 252 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 15.1 - - -
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b 35.8 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 44.4 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 1690 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 926 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 288.4 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 3467.36 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 28.84 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 50.11 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 645.65 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 0.71 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 14.3 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 4.12 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 43.2 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 13.2 - - -
reviewed BXGT014808 Nischarin reviewed Nisch >10000 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 1.2 - - -
reviewed BXGT012584 Alpha-2A adrenergic receptor reviewed Adra2a 36.31 - - -
reviewed BXGT012584 Alpha-2A adrenergic receptor reviewed Adra2a 61.66 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 0.55 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A 642 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 2258 - - -
reviewed BXGT008938 5-hydroxytryptamine receptor 3A reviewed Htr3a >10000 - - -
reviewed BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 >10000 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 280 - - -
reviewed BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 2489 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 31.62 - - -
reviewed BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 1000 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A 1258.92 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A 50.11 - - -
reviewed BXGT008472 5-hydroxytryptamine receptor 1A reviewed Htr1a 125.89 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B 158.48 - - -
reviewed BXGT004042 5-hydroxytryptamine receptor 1B reviewed HTR1B 50.11 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 19.95 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 25.11 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 1000 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 1000 - - -
reviewed BXGT008938 5-hydroxytryptamine receptor 3A reviewed Htr3a 1000 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 251.18 - - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A 199.52 - - -
reviewed BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B 158.48 - - -
reviewed BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D 158.48 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 31.62 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 7.94 - - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 63.09 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 6.3 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 3.16 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 1.99 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 0.25 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 398.1 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 501.18 - - -
reviewed BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 3981.07 - - -
reviewed BXGT008936 Sodium-dependent dopamine transporter reviewed Slc6a3 1000 - - -
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b 39.81 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 398.11 - - -
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b 50.12 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 2.5 - - -
reviewed BXGT005197 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 13.5 - - -
reviewed BXGT005197 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 11.3 - - -
reviewed BXGT005197 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 21.5 - - -
reviewed BXGT005197 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 13 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 3.5 - - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 63.6 - - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 66 - - -
reviewed BXGT008473 Alpha-2B adrenergic receptor reviewed Adra2b 16.8 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 10.6 - - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 59 - - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A 3162.28 - - -
reviewed BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B 2398.83 - - -
reviewed BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D 954.99 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 2 - - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 13 - - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 10 - - -
reviewed BXGT013955 Alpha-2A adrenergic receptor reviewed ADRA2A 49 - - -
reviewed BXGT008382 Alpha-1A adrenergic receptor reviewed ADRA1A 220 - - -
reviewed BXGT008160 Alpha-1B adrenergic receptor reviewed Adra1b 398 - - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 190 - - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 180 - - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 140 - - -
reviewed BXGT008382 Alpha-1A adrenergic receptor reviewed ADRA1A 200 - - -
reviewed BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B 1.1 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 4.6 - - -
reviewed BXGT009776 5-hydroxytryptamine receptor 2C reviewed Htr2c >10000 - - -
reviewed BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 - >20000 - -
reviewed BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D 1.6 - - -
reviewed BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B 7.2 - - -
reviewed BXGT008930 Alpha-1D adrenergic receptor reviewed Adra1d 52 - - -
reviewed BXGT008382 Alpha-1A adrenergic receptor reviewed ADRA1A 3.6 - - -
reviewed BXGT008434 Alpha-2A adrenergic receptor reviewed ADRA2A 4.4 - - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 230 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 0.5 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 - 1125 - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 15 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - 3.67 - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C - 27.1 - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - 170 - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - - 150000 -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - 398000 - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - 195000 - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - - 2300 -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - 1800 - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - - 62000 -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - - 5400000 -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - - 120 -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - - 4800 -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - - 60 -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - - 47000 -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 150 - - -
reviewed BXGT008160 Alpha-1B adrenergic receptor reviewed Adra1b - 1300 - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a - 165 - -
reviewed BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A - 33000 - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 48 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 2000 - - -
reviewed BXGT008160 Alpha-1B adrenergic receptor reviewed Adra1b 360 - - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 45 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - 8 - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 78 - - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 190 - - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 84 - - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a - 9.1 - -
reviewed BXGT008160 Alpha-1B adrenergic receptor reviewed Adra1b - 1000 - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 56 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 0.42 - - -
reviewed BXGT008448 D(3) dopamine receptor reviewed Drd3 2430 - - -
reviewed BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B 966 - - -
reviewed BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Cacna1c 45 - - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A 1057 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 2.3 - - -
reviewed BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D 289 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 7.5 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 3.1 - - -
reviewed BXGT008473 Alpha-2B adrenergic receptor reviewed Adra2b 2 - - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 8.4 - -
reviewed BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 - 95 - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 1.8 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 1.9 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A - - - 8.5
reviewed BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 - 30000 - -
reviewed BXGT009418 M-phase inducer phosphatase 1 reviewed Enzyme CDC25A - 22300 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 520 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 1621.81 - - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 431000 - -
CHEMBL CHEMBL15245
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a IC50 '=' 9 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b IC50 '=' 9 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c IC50 '=' 9 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 '=' 1000 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d IC50 '=' 1000 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 '=' 1000 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a IC50 '=' 67 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b IC50 '=' 67 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c IC50 '=' 67 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 '=' 2060 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Kd '=' 25 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Kd '=' 25 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Kd '=' 25 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Kd '=' 89 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Kd '=' 89 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Kd '=' 89 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Selectivity '=' 4 -
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Selectivity '=' 4 -
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Selectivity '=' 4 -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Selectivity '=' 4 -
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Selectivity '=' 4 -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Selectivity '=' 4 -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 4 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 4 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 4 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 54 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 54 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 54 nM
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Kd '=' 22 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Kd '=' 22 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Kd '=' 22 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b #NAME? '=' 7 -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 '=' 95 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 '=' 95 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 '=' 95 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 1 nM
P18130 BXGT008382 Alpha-1A adrenergic receptor reviewed - ADRA1A Ki '=' 200 nM
P35368 BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B Kd '=' 794 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Kd '=' 794 nM
P35348 BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A Kd '=' 794 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 '=' 17 nM
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 0 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ratio '=' 10 -
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ratio '=' 10 -
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ratio '=' 10 -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ratio '=' 10 -
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Ratio '=' 10 -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ratio '=' 10 -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 '=' 1235 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki '=' 498 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 '=' 36 nM
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki '=' 72 nM
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 '=' 1300 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d IC50 '=' 1300 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 '=' 1300 nM
P30304 BXGT009418 M-phase inducer phosphatase 1 reviewed Enzyme CDC25A IC50 '=' 22300 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a IC50 '=' 58 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b IC50 '=' 58 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c IC50 '=' 58 nM
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P35368 BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B Ki '=' 966 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 2 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Ki '=' 45 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ratio_Papp '=' 1 -
P35368 BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B Ki '=' 1 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 3 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 3 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 3 nM
Q01337 BXGT012583 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 54 nM
Q01338 BXGT012584 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 54 nM
P30545 BXGT009438 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 54 nM
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Activity - - -
P10980 BXGT007641 Muscarinic acetylcholine receptor M2 reviewed - Chrm2 IC50 - - -
P08911 BXGT006839 Muscarinic acetylcholine receptor M5 reviewed - Chrm5 IC50 - - -
P08485 BXGT006777 Muscarinic acetylcholine receptor M4 reviewed - Chrm4 IC50 - - -
P08483 BXGT006776 Muscarinic acetylcholine receptor M3 reviewed - Chrm3 IC50 - - -
P08482 BXGT006775 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 3 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 '=' 1580 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d IC50 '=' 1580 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 '=' 1580 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Activity - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 % maximum response '=' 4 %
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Inhibition - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 0 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 10 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 10 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 10 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 '=' 1800 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 '=' 1800 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 '=' 1800 nM
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Kd '=' 120 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Kd '=' 120 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Kd '=' 120 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 '=' 398000 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 '=' 398000 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 '=' 398000 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 - - -
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Selectivity ratio '=' 32 -
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Selectivity ratio '=' 32 -
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Selectivity ratio '=' 32 -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Selectivity ratio '=' 32 -
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Selectivity ratio '=' 32 -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Selectivity ratio '=' 32 -
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 78 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 78 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 78 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki '=' 190 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Kd '=' 7 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Kd '=' 7 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Kd '=' 7 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Selectivity '=' 44 -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Selectivity '=' 44 -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Selectivity '=' 44 -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki '=' 520 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Kd '=' 19 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Kd '=' 19 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Kd '=' 19 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Kd '=' 25 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Kd '=' 25 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Kd '=' 25 nM
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha reviewed Ion channel SCN3A Inhibition '=' 25 %
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha reviewed Ion channel SCN2A Inhibition '=' 25 %
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A Inhibition '=' 25 %
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 12 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 12 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 12 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Kd '=' 31 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Kd '=' 31 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Kd '=' 31 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 3 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 2 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki '=' 1 nM
Q01337 BXGT012583 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 0 nM
Q01338 BXGT012584 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 0 nM
P30545 BXGT009438 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 0 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 4 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 4 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 4 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 33 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 33 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 33 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 104 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 104 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 104 nM
P18130 BXGT008382 Alpha-1A adrenergic receptor reviewed - ADRA1A Ki '=' 3 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 0 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 0 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 0 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 70 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 70 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 70 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 '=' 170 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 '=' 170 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 '=' 170 nM
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 '>' 20000 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 '=' 8 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 '=' 8 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 '=' 8 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 '=' 1689 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 17782 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki '=' 360 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Ki '=' 360 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki '=' 360 nM
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P35348 BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A Ki '=' 1057 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 '=' 195000 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 '=' 195000 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 '=' 195000 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 0 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 7 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki '=' 180 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 22387 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A EC50 '=' 8 nM
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B pC30 '=' 8 -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C pC30 '=' 8 -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A pC30 '=' 8 -
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a IC50 '=' 30 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b IC50 '=' 30 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c IC50 '=' 30 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ratio '=' 0 -
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Ratio '=' 0 -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ratio '=' 0 -
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Selectivity index '=' -1 -
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Selectivity index '=' -1 -
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Selectivity index '=' -1 -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Selectivity index '=' -1 -
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Selectivity index '=' -1 -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Selectivity index '=' -1 -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Papp '=' 429 nm/s
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Kd '=' 123 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Kd '=' 123 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Kd '=' 123 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 7 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Kd '=' 12 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Kd '=' 12 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Kd '=' 12 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 30000 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 '=' 1188 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki '=' 658 nM
Q01337 BXGT012583 Alpha-2C adrenergic receptor reviewed - Adra2c Kd '=' 10 nM
Q01338 BXGT012584 Alpha-2A adrenergic receptor reviewed - Adra2a Kd '=' 10 nM
P30545 BXGT009438 Alpha-2B adrenergic receptor reviewed - Adra2b Kd '=' 10 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 431000 nM
Q9XUB2 BXGT022194 Zinc finger protein mex-5 reviewed - mex-5 EC50 '=' 103486 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki '=' 140 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 150 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 150 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 150 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 21192 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Kd '=' 616 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Kd '=' 616 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Kd '=' 616 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Selectivity ratio '=' 14 -
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Selectivity ratio '=' 14 -
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Selectivity ratio '=' 14 -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Selectivity ratio '=' 14 -
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Selectivity ratio '=' 14 -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Selectivity ratio '=' 14 -
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Ki '=' 52 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 0 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 0 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 0 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 5 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 5 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 5 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 8 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 8 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 8 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 52 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 52 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 52 nM
G5EF15 BXGT003524 Cytoplasmic zinc-finger protein unreviewed - pos-1 EC50 '>' 300000 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 3 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 3 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 3 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 0 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 0 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 0 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Kd '=' 60 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Kd '=' 60 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Kd '=' 60 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Kd '=' 5400000 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Kd '=' 5400000 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Kd '=' 5400000 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki '=' 289 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Kd '=' 630 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Kd '=' 630 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Kd '=' 630 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a AD50 '=' 1 mg kg-1
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b AD50 '=' 1 mg kg-1
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c AD50 '=' 1 mg kg-1
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 2 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 5 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 28 nM
P35368 BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B Kd '=' 147 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Kd '=' 147 nM
P35348 BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A Kd '=' 147 nM
Q01337 BXGT012583 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 3 nM
Q01338 BXGT012584 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 3 nM
P30545 BXGT009438 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 3 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 1 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 1 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 1 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Kd '=' 302 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Kd '=' 302 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Kd '=' 302 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Kd '=' 19 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Kd '=' 19 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Kd '=' 19 nM
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 '=' 74 nM
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 '=' 58 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 '=' 58 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 '=' 58 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki '=' 398 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Ki '=' 398 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki '=' 398 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Kd '=' 2300 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Kd '=' 2300 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Kd '=' 2300 nM
P61169 BXGT011367 D(2) dopamine receptor reviewed - Drd2 IC50 '=' 1125 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a ID50 '=' 0 mg.kg-1
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b ID50 '=' 0 mg.kg-1
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c ID50 '=' 0 mg.kg-1
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 687 nM
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ratio_ATPase activity '=' 1 -
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Selectivity index '=' 0 -
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Selectivity index '=' 0 -
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Selectivity index '=' 0 -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Selectivity index '=' 0 -
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Selectivity index '=' 0 -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Selectivity index '=' 0 -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki '=' 500 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
Q28838 BXGT013955 Alpha-2A adrenergic receptor reviewed - ADRA2A Ki '=' 49 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 1 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 1 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 1 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 2 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 2 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 2 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 35 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 35 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 35 nM
P18130 BXGT008382 Alpha-1A adrenergic receptor reviewed - ADRA1A Ki '=' 220 nM
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki '=' 784 nM
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Kd '=' 4800 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Kd '=' 4800 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Kd '=' 4800 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 '=' 1013 nM
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 112201 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 112201 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 190 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 190 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 190 nM
P34968 BXGT009776 5-hydroxytryptamine receptor 2C reviewed - Htr2c Ki '>' 10000 nM
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a #NAME? '=' 6 -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 2031 nM
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
P30994 BXGT009493 5-hydroxytryptamine receptor 2B reviewed - Htr2b #NAME? '=' 6 -
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a IC50 '=' 165 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b IC50 '=' 165 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c IC50 '=' 165 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Kd '=' 26 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Kd '=' 26 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Kd '=' 26 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 25 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 25 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 25 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 56 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 56 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 56 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ratio '=' 83 -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ratio '=' 83 -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 2909 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 4 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 8 nM
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a Ki '=' 1621 nM
P61169 BXGT011367 D(2) dopamine receptor reviewed - Drd2 Ki '=' 2000 nM
P18901 BXGT008440 D(1A) dopamine receptor reviewed - Drd1 Ki '=' 2000 nM
P30729 BXGT009461 D(4) dopamine receptor reviewed - Drd4 Ki '=' 2000 nM
P19020 BXGT008448 D(3) dopamine receptor reviewed - Drd3 Ki '=' 2000 nM
P25115 BXGT009024 D(1B) dopamine receptor reviewed - Drd5 Ki '=' 2000 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Kd '=' 263 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Kd '=' 263 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Kd '=' 263 nM
P35368 BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B Ki '=' 7 nM
P18871 BXGT008434 Alpha-2A adrenergic receptor reviewed - ADRA2A Ki '=' 4 nM
P35368 BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B Relative potency '=' 1 -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Relative potency '=' 1 -
P35348 BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A Relative potency '=' 1 -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Kd '=' 43 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Kd '=' 43 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Kd '=' 43 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Kd '=' 323 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Kd '=' 323 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Kd '=' 323 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Kd '=' 47000 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Kd '=' 47000 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Kd '=' 47000 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ratio '=' 0 -
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ratio '=' 0 -
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ratio '=' 0 -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Kd '=' 346 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Kd '=' 346 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Kd '=' 346 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 84 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 84 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 84 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 45 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 45 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 45 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 48 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 48 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 48 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 2 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 0 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 0 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 0 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P35348 BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A Kd '=' 398 nM
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Papp '=' 501 nm/s
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Kd '=' 150000 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Kd '=' 150000 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Kd '=' 150000 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Kd '=' 147 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Kd '=' 147 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Kd '=' 147 nM
P18130 BXGT008382 Alpha-1A adrenergic receptor reviewed - ADRA1A Selectivity ratio '=' 4 -
Q28838 BXGT013955 Alpha-2A adrenergic receptor reviewed - ADRA2A Selectivity ratio '=' 4 -
P30994 BXGT009493 5-hydroxytryptamine receptor 2B reviewed - Htr2b Inhibition - - -
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Kd '=' 19 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Kd '=' 19 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Kd '=' 19 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Inhibition '=' -5 %
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P19020 BXGT008448 D(3) dopamine receptor reviewed - Drd3 Ki '=' 2430 nM
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a ID50 '=' 2 mg.kg-1
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b ID50 '=' 2 mg.kg-1
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c ID50 '=' 2 mg.kg-1
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 14689 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Kd '=' 62000 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Kd '=' 62000 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Kd '=' 62000 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 '=' 6 nM
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P30994 BXGT009493 5-hydroxytryptamine receptor 2B reviewed - Htr2b pKb '=' 7 -
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 2117 nM
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 '=' 126 nM
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki '=' 47 nM
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a IC50 '=' 96 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b IC50 '=' 96 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c IC50 '=' 96 nM
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 2393 nM
P80244 BXGT011887 ATP-dependent Clp protease proteolytic subunit reviewed - clpP Potency - 14125 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 '=' 36 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 '=' 36 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 '=' 36 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 7 nM
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 254000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki '=' 230 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 9441 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 '=' 8 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 31622 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Kd '=' 1905 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Kd '=' 1905 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Kd '=' 1905 nM
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha reviewed Ion channel SCN3A IC50 '=' 33000 nM
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha reviewed Ion channel SCN2A IC50 '=' 33000 nM
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A IC50 '=' 33000 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 35481 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF05814 Rauvolfia serpentina Rauvolfia serpentina Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease