Showing entry for Glutamate--cysteine ligase regulatory subunit


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010636
Protein NameGlutamate--cysteine ligase regulatory subunit
Uniport IdP48507
GeneGCLM
Gene Id2730
DomainAldo_ket_red
Pfam PF00248  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00270 Cysteine and methionine metabolism
1. Metabolism 1.6 Metabolism of other amino acids hsa00480 Glutathione metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
4. Cellular Processes 4.2 Cell growth and death hsa04216 Ferroptosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:0008637 apoptotic mitochondrial changes
Biological Process GO:0044344 cellular response to fibroblast growth factor stimulus
Biological Process GO:0071372 cellular response to follicle-stimulating hormone stimulus
Biological Process GO:0071333 cellular response to glucose stimulus
Biological Process GO:0035729 cellular response to hepatocyte growth factor stimulus
Biological Process GO:1990830 cellular response to leukemia inhibitory factor
Biological Process GO:0097069 cellular response to thyroxine stimulus
Biological Process GO:0006534 cysteine metabolic process
Biological Process GO:0006536 glutamate metabolic process
Biological Process GO:0006750 glutathione biosynthetic process
Biological Process GO:0035733 hepatic stellate cell activation
Biological Process GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0035229 positive regulation of glutamate-cysteine ligase activity
Biological Process GO:0097746 regulation of blood vessel diameter
Biological Process GO:0051900 regulation of mitochondrial depolarization
Biological Process GO:0014823 response to activity
Biological Process GO:0042493 response to drug
Biological Process GO:0044752 response to human chorionic gonadotropin
Biological Process GO:0051409 response to nitrosative stress
Biological Process GO:0007584 response to nutrient
Biological Process GO:0006979 response to oxidative stress
molecular function GO:0030234 enzyme regulator activity
molecular function GO:0004357 glutamate-cysteine ligase activity
molecular function GO:0035226 glutamate-cysteine ligase catalytic subunit binding
molecular function GO:0044877 protein-containing complex binding
cellular component GO:0005829 cytosol
cellular component GO:0017109 glutamate-cysteine ligase complex
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-156590 Glutathione conjugation
R-HSA-1643685 Disease
R-HSA-174403 Glutathione synthesis and recycling
R-HSA-211859 Biological oxidations
R-HSA-5578999 Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
R-HSA-5579029 Metabolic disorders of biological oxidation enzymes
R-HSA-5668914 Diseases of metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002878 BXGD000137 Anemia, Hemolytic Hemic and Lymphatic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005138 BXGD000306 Berylliosis Respiratory Tract Diseases; Occupational Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018203 BXGD001184 Chronic granulomatous disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0025500 BXGD001874 Mesothelioma Neoplasms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033937 BXGD002442 Psychoses, Drug Chemically-Induced Disorders; Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036939 BXGD002646 Shared Paranoid Disorder Mental Disorders
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042961 BXGD003017 Intestinal Volvulus Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0086541 BXGD003293 Urban cutaneous leishmaniasis Infections; Skin and Connective Tissue Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0160390 BXGD003921 Injury of liver Digestive System Diseases; Wounds and Injuries
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0265964 BXGD005591 Mutilating keratoderma Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0426980 BXGD008599 Motor symptoms
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832662 BXGD013867 MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1969372 BXGD016775 Tubulointerstitial fibrosis
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2350873 BXGD017083 Beryllium Disease Respiratory Tract Diseases; Occupational Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2939094 BXGD018171 Skin sensitisation
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006162 L-Glutamic acid 147.13
BXGC0006271 L-Cysteine 121.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein