acompound

Showing entry for Beta-Lapachone

General Compound Information
BXGC Id	BXGC0028001
Compound Name	Beta-Lapachone
Structure
Formula	C15H14O3
InchiKey	QZPQTZZNNJUOLS-UHFFFAOYSA-N
SMILES	O=C1C2=C(OC(CC2)(C)C)c2c(C1=O)cccc2
Inchi	InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
IUPAC	2,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione
Molecular Weight	242.09
Pubchem Id	3885
Chembl Id	CHEMBL15192

Targets of Information Source

DrugBank

DB11948

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
P10745	BXGT007608	Retinol-binding protein 3	reviewed	-	RBP3	investigational	-

PDB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1

Binding DB

81348

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT008715	Protein-glutamine gamma-glutamyltransferase 2	reviewed	Enzyme	TGM2	-	1800	-	-
reviewed	BXGT009349	Caspase-1	reviewed	Enzyme	CASP1	-	1690	-	-
reviewed	BXGT002006	Lysine-specific demethylase 4E	reviewed		KDM4E	-	3000	-	-
reviewed	BXGT021670	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	reviewed	Enzyme	MALT1	-	1200	-	-
reviewed	BXGT021670	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	reviewed	Enzyme	MALT1	-	1900	-	-
reviewed	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	reviewed		NQO1	-	>10000	-	-
reviewed	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	reviewed		NQO1	-	3400	-	-
reviewed	BXGT002006	Lysine-specific demethylase 4E	reviewed		KDM4E	3550	-	-	-
reviewed	BXGT005384	Tyrosyl-DNA phosphodiesterase 2	reviewed		TDP2	-	970	-	-

CHEMBL

CHEMBL15192

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
Q96KQ7	BXGT019687	Histone-lysine N-methyltransferase EHMT2	reviewed	Epigenetic regulator	EHMT2	Potency	-	14125	nM
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	AC50	'='	15848	nM
O89049	BXGT005293	Thioredoxin reductase 1, cytoplasmic	reviewed	-	Txnrd1	Potency	-	25118	nM
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	reviewed	Enzyme	TDP1	Potency	'='	39810	nM
Q16637	BXGT013646	Survival motor neuron protein	reviewed	Epigenetic regulator	SMN1	Potency	'='	25118	nM
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	Potency	'='	15848	nM
P11473	BXGT007709	Vitamin D3 receptor	reviewed	Nuclear receptor	VDR	Potency	-	20596	nM
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	reviewed	Transcription factor	SMAD3	Potency	-	3162	nM
P46063	BXGT010501	ATP-dependent DNA helicase Q1	reviewed	Enzyme	RECQL	Potency	'='	17782	nM
O97447	BXGT005436	Putative fructose-1,6-bisphosphate aldolase	unreviewed	-	ald	Potency	'='	1990	nM
O89049	BXGT005293	Thioredoxin reductase 1, cytoplasmic	reviewed	-	Txnrd1	Potency	-	17782	nM
P00352	BXGT005510	Retinal dehydrogenase 1	reviewed	Enzyme	ALDH1A1	Potency	'='	39810	nM
B2RXH2	BXGT002006	Lysine-specific demethylase 4E	reviewed	-	KDM4E	Potency	'='	3548	nM
P10636	BXGT007596	Microtubule-associated protein tau	reviewed	-	MAPT	Potency	'='	15848	nM
Q9UDY8	BXGT021670	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	reviewed	Enzyme	MALT1	IC50	'='	1200	nM
O15296	BXGT004148	Arachidonate 15-lipoxygenase B	reviewed	Enzyme	ALOX15B	Potency	-	39810	nM
P10636	BXGT007596	Microtubule-associated protein tau	reviewed	-	MAPT	Potency	'='	10000	nM
P10828	BXGT007624	Thyroid hormone receptor beta	reviewed	Nuclear receptor	THRB	Potency	'='	5011	nM
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	reviewed	Transcription factor	NFKB1	Potency	'='	8912	nM
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	reviewed	-	NQO1	Drug metabolism	'='	1210	micromol/min
P23141	BXGT008830	Liver carboxylesterase 1	reviewed	Enzyme	CES1	Ki	'='	1220	nM
Q13951	BXGT013407	Core-binding factor subunit beta	reviewed	-	CBFB	Potency	-	17782	nM
Q01196	BXGT012575	Runt-related transcription factor 1	reviewed	Transcription factor	RUNX1	Potency	-	17782	nM
Q13526	BXGT013369	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	reviewed	-	PIN1	Potency	-	19011	nM
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	reviewed	-	NQO1	Kcat/Km	'='	2	10'6/M/s
P83916	BXGT012025	Chromobox protein homolog 1	reviewed	Epigenetic regulator	CBX1	Potency	-	79432	nM
P33261	BXGT009707	Cytochrome P450 2C19	reviewed	-	CYP2C19	Potency	'='	3981	nM
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	AC50	'='	3981	nM
P11473	BXGT007709	Vitamin D3 receptor	reviewed	Nuclear receptor	VDR	Potency	-	14125	nM
Q96QE3	BXGT019718	ATPase family AAA domain-containing protein 5	reviewed	-	ATAD5	Potency	-	16353	nM
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	reviewed	Transcription factor	HIF1A	Potency	'='	31622	nM
P16050	BXGT008184	Arachidonate 15-lipoxygenase	reviewed	Enzyme	ALOX15	Potency	'='	15848	nM
P05067	BXGT006306	Amyloid-beta precursor protein	reviewed	Enzyme modulator	APP	Potency	-	29092	nM
P51151	BXGT010837	Ras-related protein Rab-9A	reviewed	-	RAB9A	Potency	'='	58047	nM
P40225	BXGT010168	Thrombopoietin	reviewed	-	THPO	Potency	'='	1584	nM
P10636	BXGT007596	Microtubule-associated protein tau	reviewed	-	MAPT	Potency	'='	12589	nM
Q16637	BXGT013646	Survival motor neuron protein	reviewed	Epigenetic regulator	SMN1	Potency	'='	15848	nM
P11473	BXGT007709	Vitamin D3 receptor	reviewed	Nuclear receptor	VDR	Potency	-	8912	nM
P10635	BXGT007595	Cytochrome P450 2D6	reviewed	-	CYP2D6	AC50	'='	15848	nM
O89049	BXGT005293	Thioredoxin reductase 1, cytoplasmic	reviewed	-	Txnrd1	Potency	-	37685	nM
Q9UNA4	BXGT021785	DNA polymerase iota	reviewed	-	POLI	Potency	-	7943	nM
Q9UNA4	BXGT021785	DNA polymerase iota	reviewed	-	POLI	Potency	-	8912	nM
P10636	BXGT007596	Microtubule-associated protein tau	reviewed	-	MAPT	Potency	'='	5011	nM
B2RXH2	BXGT002006	Lysine-specific demethylase 4E	reviewed	-	KDM4E	IC50	'='	3000	nM
P46063	BXGT010501	ATP-dependent DNA helicase Q1	reviewed	Enzyme	RECQL	Potency	'='	39810	nM
O89049	BXGT005293	Thioredoxin reductase 1, cytoplasmic	reviewed	-	Txnrd1	Potency	-	18887	nM
P33261	BXGT009707	Cytochrome P450 2C19	reviewed	-	CYP2C19	AC50	'='	3981	nM
P08482	BXGT006775	Muscarinic acetylcholine receptor M1	reviewed	-	Chrm1	Potency	'='	14125	nM
O75496	BXGT005132	Geminin	reviewed	-	GMNN	Potency	'='	31622	nM
P51450	BXGT010847	Nuclear receptor ROR-gamma	reviewed	-	Rorc	Potency	'='	2511	nM
P11021	BXGT007644	Endoplasmic reticulum chaperone BiP	reviewed	-	HSPA5	Potency	-	14689	nM
P02545	BXGT005889	Prelamin-A/C	reviewed	-	LMNA	Potency	'='	25118	nM
P00352	BXGT005510	Retinal dehydrogenase 1	reviewed	Enzyme	ALDH1A1	Potency	'='	14125	nM
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	reviewed	Kinase	MTOR	Potency	'='	26121	nM
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	reviewed	Enzyme	NFE2L2	Potency	-	29092	nM
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	Potency	'='	31622	nM
Q99549	BXGT019932	M-phase phosphoprotein 8	reviewed	Epigenetic regulator	MPHOSPH8	Potency	-	26679	nM
Q9NR56	BXGT021179	Muscleblind-like protein 1	reviewed	Nucleic acid binding	MBNL1	Potency	-	14125	nM
P16435	BXGT008226	NADPH--cytochrome P450 reductase	reviewed	-	POR	GI	-	-	-
Q6W5P4	BXGT016588	Neuropeptide S receptor	reviewed	-	NPSR1	Potency	'='	3162	nM
P39748	BXGT010134	Flap endonuclease 1	reviewed	Enzyme	FEN1	Potency	-	3548	nM
P51450	BXGT010847	Nuclear receptor ROR-gamma	reviewed	-	Rorc	Potency	'='	5623	nM
B2RXH2	BXGT002006	Lysine-specific demethylase 4E	reviewed	-	KDM4E	Ki	'='	3550	nM
P10636	BXGT007596	Microtubule-associated protein tau	reviewed	-	MAPT	Potency	'='	11220	nM
P06280	BXGT006433	Alpha-galactosidase A	reviewed	-	GLA	Potency	'='	8912	nM
P08482	BXGT006775	Muscarinic acetylcholine receptor M1	reviewed	-	Chrm1	Potency	'='	8912	nM
P54132	BXGT011032	Bloom syndrome protein	reviewed	-	BLM	Potency	'='	25118	nM
Q9Y253	BXGT022216	DNA polymerase eta	reviewed	-	POLH	Potency	-	22387	nM
O00519	BXGT003934	Fatty-acid amide hydrolase 1	reviewed	-	FAAH	Inhibition	'='	25	%
P28482	BXGT009263	Mitogen-activated protein kinase 1	reviewed	Kinase	MAPK1	Potency	'='	31622	nM
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	reviewed	Kinase	MTOR	Potency	'='	13091	nM
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	AC50	'='	31622	nM
P10828	BXGT007624	Thyroid hormone receptor beta	reviewed	Nuclear receptor	THRB	Potency	'='	35481	nM
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	reviewed	Enzyme	TDP1	Potency	-	5623	nM
O15648	BXGT004185	ATP-dependent 6-phosphofructokinase	reviewed	-	pfk	Potency	-	756	nM
Q01453	BXGT012588	Peripheral myelin protein 22	reviewed	Cellular structure	PMP22	Potency	'='	37933	nM
Q16637	BXGT013646	Survival motor neuron protein	reviewed	Epigenetic regulator	SMN1	Potency	'='	7079	nM
P49798	BXGT010745	Regulator of G-protein signaling 4	reviewed	Enzyme modulator	RGS4	Potency	-	15003	nM
P10635	BXGT007595	Cytochrome P450 2D6	reviewed	-	CYP2D6	Potency	'='	15848	nM
Q99700	BXGT019949	Ataxin-2	reviewed	Nucleic acid binding	ATXN2	Potency	-	28183	nM
P02545	BXGT005889	Prelamin-A/C	reviewed	-	LMNA	Potency	'='	5	nM
P07378	BXGT006616	Phosphoglycerate kinase, glycosomal	reviewed	-		Potency	-	37933	nM
P10636	BXGT007596	Microtubule-associated protein tau	reviewed	-	MAPT	Potency	'='	31622	nM
Q9NR56	BXGT021179	Muscleblind-like protein 1	reviewed	Nucleic acid binding	MBNL1	Potency	-	19952	nM
O75496	BXGT005132	Geminin	reviewed	-	GMNN	Potency	-	9200	nM
P04637	BXGT006243	Cellular tumor antigen p53	reviewed	Transcription factor	TP53	Potency	'='	5011	nM
O97447	BXGT005436	Putative fructose-1,6-bisphosphate aldolase	unreviewed	-	ald	Potency	'='	1581	nM
P16435	BXGT008226	NADPH--cytochrome P450 reductase	reviewed	-	POR	IC50	'='	11000	nM
P28482	BXGT009263	Mitogen-activated protein kinase 1	reviewed	Kinase	MAPK1	Potency	'='	39810	nM
Q13951	BXGT013407	Core-binding factor subunit beta	reviewed	-	CBFB	Potency	-	22387	nM
Q01196	BXGT012575	Runt-related transcription factor 1	reviewed	Transcription factor	RUNX1	Potency	-	22387	nM
P97697	BXGT012214	Inositol monophosphatase 1	reviewed	-	Impa1	Potency	'='	11220	nM
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	reviewed	Enzyme	TDP1	Potency	-	2310	nM
O89049	BXGT005293	Thioredoxin reductase 1, cytoplasmic	reviewed	-	Txnrd1	Potency	-	39810	nM
P39748	BXGT010134	Flap endonuclease 1	reviewed	Enzyme	FEN1	Potency	-	21192	nM
O00748	BXGT003942	Cocaine esterase	reviewed	Enzyme	CES2	Inhibition	-	-	-
O42275	BXGT004559	Acetylcholinesterase	reviewed	-	ache	Inhibition	'='	-2	%
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	reviewed	-	KMT2A	Potency	'='	39810	nM
O00255	BXGT003903	Menin	reviewed	-	MEN1	Potency	'='	39810	nM
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	reviewed	-	NQO1	Activity	-	-	-
Q99700	BXGT019949	Ataxin-2	reviewed	Nucleic acid binding	ATXN2	Potency	-	22387	nM
P37840	BXGT010015	Alpha-synuclein	reviewed	Transporter	SNCA	Potency	-	22387	nM
P11388	BXGT007697	DNA topoisomerase 2-alpha	reviewed	-	TOP2A	Inhibition	-	-	-
Q12809	BXGT013267	Potassium voltage-gated channel subfamily H member 2	reviewed	Ion channel	KCNH2	Potency	-	15848	nM
P11473	BXGT007709	Vitamin D3 receptor	reviewed	Nuclear receptor	VDR	Potency	-	11220	nM
Q9F4F7	BXGT020344	4'-phosphopantetheinyl transferase ffp	reviewed	-	ffp	Potency	'='	63095	nM
P02791	BXGT005965	Ferritin light chain	reviewed	-	FTL	Potency	'='	15848	nM
O94782	BXGT005332	Ubiquitin carboxyl-terminal hydrolase 1	reviewed	Enzyme	USP1	Potency	-	8348	nM
P81908	BXGT011959	Cholinesterase	reviewed	-	BCHE	Inhibition	'='	11	%
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	reviewed	Enzyme	TDP1	Potency	-	2818	nM
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	reviewed	-	NQO1	IC50	'>'	10000	nM
P15289	BXGT008102	Arylsulfatase A	reviewed	Enzyme	ARSA	Potency	-	3380	nM
P14902	BXGT008065	Indoleamine 2,3-dioxygenase 1	reviewed	-	IDO1	Ki	'='	100	nM
P11473	BXGT007709	Vitamin D3 receptor	reviewed	Nuclear receptor	VDR	Potency	-	31622	nM
P51570	BXGT010858	Galactokinase	reviewed	Kinase	GALK1	Potency	-	35481	nM
Q04206	BXGT012754	Transcription factor p65	reviewed	Transcription factor	RELA	IC50	'='	4000	nM
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	reviewed	Transcription factor	NFKB1	IC50	'='	4000	nM
Q00653	BXGT012541	Nuclear factor NF-kappa-B p100 subunit	reviewed	Transcription factor	NFKB2	IC50	'='	4000	nM
P23141	BXGT008830	Liver carboxylesterase 1	reviewed	Enzyme	CES1	Activity	'='	12	%
P46063	BXGT010501	ATP-dependent DNA helicase Q1	reviewed	Enzyme	RECQL	Potency	'='	112201	nM
Q9Z1B7	BXGT022403	Mitogen-activated protein kinase 13	reviewed	-	Mapk13	Inhibition	-	-	-
Q9WUI1	BXGT021940	Mitogen-activated protein kinase 11	reviewed	-	Mapk11	Inhibition	-	-	-
O08911	BXGT004043	Mitogen-activated protein kinase 12	reviewed	-	Mapk12	Inhibition	-	-	-
P47811	BXGT010587	Mitogen-activated protein kinase 14	reviewed	-	Mapk14	Inhibition	-	-	-
P21728	BXGT008686	D(1A) dopamine receptor	reviewed	G-protein coupled receptor	DRD1	Potency	-	461	nM
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	reviewed	-	NQO1	Activity	'='	1146	micromol/min
O94782	BXGT005332	Ubiquitin carboxyl-terminal hydrolase 1	reviewed	Enzyme	USP1	Potency	-	5011	nM
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	reviewed	Enzyme	TDP1	Potency	-	4610	nM
P11473	BXGT007709	Vitamin D3 receptor	reviewed	Nuclear receptor	VDR	Potency	-	39810	nM
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	reviewed	-	NQO1	Activity	'='	1258	micromol/min
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	reviewed	-	NQO1	IC50	'='	3000	nM
Q9UDY8	BXGT021670	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	reviewed	Enzyme	MALT1	IC50	'='	1900	nM
Q9NR56	BXGT021179	Muscleblind-like protein 1	reviewed	Nucleic acid binding	MBNL1	Potency	-	31622	nM
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	reviewed	-	NQO1	IC50	'='	3400	nM
P16435	BXGT008226	NADPH--cytochrome P450 reductase	reviewed	-	POR	Activity	-	-	-
O00748	BXGT003942	Cocaine esterase	reviewed	Enzyme	CES2	Ki	'='	109	nM
O00748	BXGT003942	Cocaine esterase	reviewed	Enzyme	CES2	Activity	'='	6	%
P16435	BXGT008226	NADPH--cytochrome P450 reductase	reviewed	-	POR	Activity	'='	923	micromol/min
P22303	BXGT008751	Acetylcholinesterase	reviewed	Enzyme	ACHE	Inhibition	'='	10	%
O95551	BXGT005384	Tyrosyl-DNA phosphodiesterase 2	reviewed	-	TDP2	IC50	'='	970	nM
P23141	BXGT008830	Liver carboxylesterase 1	reviewed	Enzyme	CES1	Inhibition	-	-	-
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	reviewed	-	NQO1	Activity	'='	15	nmol/mg
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	reviewed	-	NQO1	Kcat/Km	'='	4	10'6/M/s

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF02724	Tectona grandis	Tectona grandis	Medicinal Plant
BXGF05354	Tabebuia avellanedae	Tabebuia avellanedae	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}