Showing entry for Gossypol


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000430
Compound NameGossypol
Structure
FormulaC30H30O8
InchiKeyQBKSWRVVCFFDOT-UHFFFAOYSA-N
SMILESCC(C)C1=C2C=C(C)C(=C(O)C2=C(C=O)C(O)=C1O)C1=C(O)C2=C(C=O)C(O)=C(O)C(C(C)C)=C2C=C1C
InchiInChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
IUPAC7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carbaldehyde
Molecular Weight518.55
Pubchem Id3503
Chembl IdCHEMBL51483
Targets of Information Source
DrugBank DB13044
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 investigational -
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 23223
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT013932 L-lactate dehydrogenase reviewed - - 2640 - -
reviewed BXGT015339 L-lactate dehydrogenase B chain reviewed LDHB - 9540 - -
reviewed BXGT005508 Malate dehydrogenase, mitochondrial reviewed MDH2 - 2800 - -
reviewed BXGT007737 Malate dehydrogenase, cytoplasmic reviewed MDH1 - 5800 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 2551.34 - -
reviewed BXGT011103 Transitional endoplasmic reticulum ATPase reviewed VCP - 5386 - -
reviewed BXGT011103 Transitional endoplasmic reticulum ATPase reviewed VCP - 15540 - -
reviewed BXGT012771 Eukaryotic translation initiation factor 4 gamma 1 reviewed Nucleic acid binding EIF4G1 - 64000 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 50000 - -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 - 1355.6921 - -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 - 1523.102004 - -
reviewed BXGT009349 Caspase-1 reviewed Enzyme CASP1 - 1230 - -
reviewed BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 - 2720 - -
reviewed BXGT008083 Aldo-keto reductase family 1 member B1 reviewed Enzyme AKR1B1 500 - - -
reviewed BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 - 260 - -
reviewed BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 - 480 - -
reviewed BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 - 4571 - -
reviewed BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 - 3236 - -
reviewed BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 1000 - - -
reviewed BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 620 - - -
reviewed BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 320 - - -
reviewed BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 - 500 - -
reviewed BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 480 - - -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 180 - - -
reviewed BXGT009336 DNA-3-methyladenine glycosylase reviewed Enzyme MPG - 3000 - -
reviewed BXGT005666 Beta-lactamase reviewed ampC - 46000 - -
reviewed BXGT005666 Beta-lactamase reviewed ampC - 82000 - -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 280 - - -
reviewed BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 170 - - -
reviewed BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 640 - - -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 310 - - -
reviewed BXGT005504 L-lactate dehydrogenase A chain reviewed Enzyme LDHA 1900 - - -
reviewed BXGT006563 L-lactate dehydrogenase B chain reviewed Enzyme LDHB 1400 - - -
reviewed BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 - - 1710 -
reviewed BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 - - 338000 -
reviewed BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 440 - - -
reviewed BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 310 - - -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 640 - - -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 - 856 - -
reviewed BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 - 1191 - -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 162 - - -
reviewed BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 511 - - -
reviewed BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 1400 - - -
reviewed BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 450 - - -
reviewed BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 - 500 - -
reviewed BXGT019384 Bcl-2-like protein 2 reviewed Signaling BCL2L2 17700 - - -
reviewed BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 10100 - - -
reviewed BXGT010948 Kinesin-like protein KIF11 reviewed Cellular structure KIF11 - 25000 - -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 6543 - - -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 - - 2324 -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 190 - - -
reviewed BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 - - 4800 -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 - - 2650 -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 - 4800 - -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 - 170 - -
reviewed BXGT010948 Kinesin-like protein KIF11 reviewed Cellular structure KIF11 - 10800 - -
reviewed BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 - 2110 - -
reviewed BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 558 - - -
reviewed BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 3470 - - -
reviewed BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 1780 - - -
CHEMBL CHEMBL51483
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 15848 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 31622 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 25118 nM
O81014 BXGT005204 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic reviewed - ISPE Potency '=' 47269 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 IC50 '=' 480 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 1995 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 9528 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Ki '=' 190 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 19952 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 15848 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 '=' 31622 nM
P37840 BXGT010015 Alpha-synuclein reviewed Transporter SNCA Potency - 7079 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 25118 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 25118 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 10000 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 10000 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Ki '=' 390 nM
Q9WKE8 BXGT021921 Reverse transcriptase unreviewed - reverse Inhibition '=' 73 %
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 15003 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC IC50 '=' 46000 nM
P37840 BXGT010015 Alpha-synuclein reviewed Transporter SNCA Potency - 6513 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 39810 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 22387 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 IC50 '=' 500 nM
P52732 BXGT010948 Kinesin-like protein KIF11 reviewed Cellular structure KIF11 IC50 '=' 25000 nM
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 50118 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 25118 nM
Q9WKE8 BXGT021921 Reverse transcriptase unreviewed - reverse Inhibition - - -
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 19905 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 10000 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 3548 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 6309 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 IC50 '=' 300 nM
P02768 BXGT005955 Serum albumin reviewed Transporter ALB Ka '=' 2 10'5L/mol
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 Ki '=' 558 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 14125 nM
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 15003 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 IC50 '=' 4800 nM
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 15848 nM
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 46451 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 17782 nM
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 25118 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 25118 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 IC50 '=' 4570 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 2238 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 14125 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 31622 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 19952 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 5011 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 50118 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 12589 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 44668 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 5011 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 3548 nM
O75604 BXGT005139 Ubiquitin carboxyl-terminal hydrolase 2 reviewed Enzyme USP2 Potency '=' 1995 nM
P00338 BXGT005504 L-lactate dehydrogenase A chain reviewed Enzyme LDHA Ki '=' 1900 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Ki '=' 640 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 15848 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 31622 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 2612 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 31622 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 31622 nM
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 39810 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC IC50 '=' 82000 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 25118 nM
P07947 BXGT006701 Tyrosine-protein kinase Yes reviewed Kinase YES1 Potency - 30747 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 29092 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 5623 nM
O75604 BXGT005139 Ubiquitin carboxyl-terminal hydrolase 2 reviewed Enzyme USP2 Potency '=' 5211 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 22387 nM
P55210 BXGT011110 Caspase-7 reviewed Enzyme CASP7 Potency '=' 15848 nM
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Potency '=' 12589 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 2551 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 IC50 '=' 540 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 35481 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 15811 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 15848 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 28183 nM
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Potency '=' 25118 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 10000 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 19952 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 14581 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 28183 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 14689 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 39810 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 28183 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 35481 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 '=' 6309 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 Ki '=' 170 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 5011 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 39810 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 5323 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 22387 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 27306 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 25118 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Potency '=' 2511 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 35481 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 Activity - - -
O75604 BXGT005139 Ubiquitin carboxyl-terminal hydrolase 2 reviewed Enzyme USP2 Potency '=' 25118 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 22387 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 IC50 '=' 1523 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 10000 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 Ki '=' 640 nM
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha reviewed Nuclear receptor PPARA Potency - 15848 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Ki '=' 213 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 '=' 31622 nM
Q4Q090 BXGT014858 2,3-bisphosphoglycerate-independent phosphoglycerate mutase unreviewed - PGAM Potency - 15 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 Ki '=' 10100 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 31622 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 7943 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 25118 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 7079 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 IC50 '=' 170 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 50118 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 7943 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 11220 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 25118 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 12589 nM
Q0PJ46 BXGT013140 Lactate dehydrogenase unreviewed - LDH IC50 '=' 2640 nM
P55210 BXGT011110 Caspase-7 reviewed Enzyme CASP7 Potency '=' 19952 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 14125 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 7943 nM
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 19011 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 31622 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 15848 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 3981 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 86349 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 50118 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 8912 nM
Q6W5P4 BXGT016588 Neuropeptide S receptor reviewed - NPSR1 Potency '=' 12589 nM
P37059 BXGT009957 Estradiol 17-beta-dehydrogenase 2 reviewed Enzyme HSD17B2 Activity '=' 64 %
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 26679 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 Kd '=' 338000 nM
P13267 BXGT007895 DNA polymerase III PolC-type reviewed - polC Potency - 10621 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 14125 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Ki '=' 260 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 91999 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 12589 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 794 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 IC50 '=' 600 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 Ki '=' 420 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 Ki '=' 480 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 15848 nM
Q6VVP7 BXGT016584 Malate dehydrogenase unreviewed - IC50 '=' 2030 nM
P00346 BXGT005508 Malate dehydrogenase, mitochondrial reviewed - MDH2 IC50 '=' 2800 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 31622 nM
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 4224 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 58047 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 Ki '=' 511 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 3548 nM
P51570 BXGT010858 Galactokinase reviewed Kinase GALK1 Potency '=' 23690 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 17782 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 68 %
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 10000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 7499 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Kd '=' 2630 nM
O75604 BXGT005139 Ubiquitin carboxyl-terminal hydrolase 2 reviewed Enzyme USP2 Potency '=' 19952 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 22387 nM
P07378 BXGT006616 Phosphoglycerate kinase, glycosomal reviewed - Potency - 23934 nM
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 reviewed Transporter SLC2A1 Ki '=' 20000 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Ki '=' 280 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 - - -
Q92843 BXGT019384 Bcl-2-like protein 2 reviewed Signaling BCL2L2 Ki '=' 17700 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' -12 %
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Potency '=' 15848 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 12589 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Kd '=' 2650 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 35481 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 IC50 '=' 260 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Potency '=' 5011 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 Ki '=' 320 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 31622 nM
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 14125 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 14125 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 14125 nM
P55210 BXGT011110 Caspase-7 reviewed Enzyme CASP7 Potency '=' 12589 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency - 25118 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Ki '=' 180 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 1122 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 Kd '=' 1710 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 8912 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 562 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 40533 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 31622 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 17782 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 11220 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 31622 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 31622 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 39810 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 10000 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 35481 nM
P63073 BXGT011490 Eukaryotic translation initiation factor 4E reviewed - Eif4e IC50 - 64000 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 1258 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 18356 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 11917 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 12589 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 17782 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 14125 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 Kd '=' 4800 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 19952 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 Ki '=' 770 nM
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 2818 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 2818 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 IC50 '=' 2720 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 10000 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 IC50 '=' 3235 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 9466 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 35481 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 15848 nM
P42858 BXGT010341 Huntingtin reviewed - HTT Potency '=' 12589 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 35481 nM
P52732 BXGT010948 Kinesin-like protein KIF11 reviewed Cellular structure KIF11 IC50 '=' 10800 nM
Q962Y6 BXGT019597 Thioredoxin glutathione reductase unreviewed - TGR Potency '=' 50118 nM
P15121 BXGT008083 Aldo-keto reductase family 1 member B1 reviewed Enzyme AKR1B1 Ki '=' 500 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 251 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 50118 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 7943 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 24 %
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 19952 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 5804 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Ki '=' 6543 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' -2 %
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 1694 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 8196 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 IC50 '=' 500 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 8912 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Ki '=' 200 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Kd '=' 2324 nM
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 12589 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 2511 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 2818 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Ki '=' 310 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 58 %
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 22387 nM
Q9R1A7 BXGT021413 Nuclear receptor subfamily 1 group I member 2 reviewed - Nr1i2 Potency - 31622 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Ki '=' 3470 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 56234 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 Ki '=' 1000 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 15 %
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 28183 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 6309 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 Inhibition '=' 100 %
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 Ki '=' 467 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 562 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 11220 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 22334 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 10000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 6683 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 10000 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 44668 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 '=' 15848 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 8912 nM
P29372 BXGT009336 DNA-3-methyladenine glycosylase reviewed Enzyme MPG IC50 '=' 3000 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 35481 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 26121 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Inhibition - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 12589 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Potency '=' 891 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 IC50 '=' 2110 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 6309 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency - 12589 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 10000 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 Ki '=' 1400 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 15848 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 2511 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 3162 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 Ki '=' 440 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 IC50 '=' 856 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 10621 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Potency - 44668 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 37933 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 11220 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 15848 nM
P07195 BXGT006563 L-lactate dehydrogenase B chain reviewed Enzyme LDHB Ki '=' 1400 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 15848 nM
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 IC50 - - -
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 35481 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 12589 nM
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 79432 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 Ki '=' 560 nM
P11708 BXGT007737 Malate dehydrogenase, cytoplasmic reviewed - MDH1 IC50 '=' 5800 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 10000 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 Inhibition '=' 100 %
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 7079 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 Ki '=' 620 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 Ki '=' 310 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Ki '=' 1780 nM
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Activity '=' 60 %
P37059 BXGT009957 Estradiol 17-beta-dehydrogenase 2 reviewed Enzyme HSD17B2 IC50 - - -
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Ki '=' 162 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Potency '=' 316 nM
Q9WKE8 BXGT021921 Reverse transcriptase unreviewed - reverse Inhibition '=' 76 %
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 Ki '=' 450 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 IC50 '=' 1191 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 Ki '=' 431 nM
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 reviewed Nucleic acid binding MDM2 Ki '>' 25000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00085 Soy bean Glycine max Soy
BXGF00086 Sunflower Helianthus annuus Herbs and Spices
BXGF00315 Cottonseed Gossypium Herbs and Spices
BXGF00387 Okra Abelmoschus esculentus Vegetables
BXGF00816 Fats and oils Fats and oils
BXGF01132 Gossypium herbaceum Gossypium herbaceum Medicinal Plant
BXGF02875 Thespesia populnea Thespesia populnea Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease