Showing entry for Aldo-keto reductase family 1 member C2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010961
Protein NameAldo-keto reductase family 1 member C2
Uniport IdP52895
GeneAKR1C2
Gene Id1646
DomainAldo_ket_red
Pfam PF00248  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00140 Steroid hormone biosynthesis
6. Human Diseases 6.1 Cancers: Overview hsa05204 Chemical carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008207 C21-steroid hormone metabolic process
Biological Process GO:0071395 cellular response to jasmonic acid stimulus
Biological Process GO:0071799 cellular response to prostaglandin D stimulus
Biological Process GO:0044597 daunorubicin metabolic process
Biological Process GO:0007586 digestion
Biological Process GO:0044598 doxorubicin metabolic process
Biological Process GO:0030855 epithelial cell differentiation
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:0042448 progesterone metabolic process
Biological Process GO:0006693 prostaglandin metabolic process
Biological Process GO:0008202 steroid metabolic process
molecular function GO:0008106 alcohol dehydrogenase (NADP+) activity
molecular function GO:0004032 alditol:NADP+ 1-oxidoreductase activity
molecular function GO:0047023 androsterone dehydrogenase activity
molecular function GO:0032052 bile acid binding
molecular function GO:0031406 carboxylic acid binding
molecular function GO:0047086 ketosteroid monooxygenase activity
molecular function GO:0016491 oxidoreductase activity
molecular function GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
molecular function GO:0018636 phenanthrene 9,10-monooxygenase activity
molecular function GO:0005496 steroid binding
molecular function GO:0016229 steroid dehydrogenase activity
molecular function GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-192105 Synthesis of bile acids and bile salts
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-194068 Bile acid and bile salt metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004763 BXGD000289 Barrett Esophagus Digestive System Diseases; Neoplasms
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007621 BXGD000468 Neoplastic Cell Transformation Pathological Conditions, Signs and Symptoms; Neoplasms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011430 BXGD000723 Dentin Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0011436 BXGD000726 Dentinogenesis Imperfecta Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011616 BXGD000739 Contact Dermatitis Skin and Connective Tissue Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011880 BXGD000759 Diabetic Ketoacidosis Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0019269 BXGD001310 Hermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0025500 BXGD001874 Mesothelioma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027661 BXGD002014 Neoplasms, Hormone-Dependent Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033804 BXGD002426 Pseudohermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0036875 BXGD002640 Disorders of Sex Development Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0042131 BXGD002959 Uterine Diseases Female Urogenital Diseases and Pregnancy Complications
C0043094 BXGD003026 Weight Gain Pathological Conditions, Signs and Symptoms
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0086743 BXGD003308 Osteoarthrosis Deformans Musculoskeletal Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0162351 BXGD003938 Contact hypersensitivity Skin and Connective Tissue Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0238395 BXGD004922 Male Pseudohermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0266362 BXGD005657 Ambiguous Genitalia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0268398 BXGD005933 Familial lichen amyloidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279628 BXGD006659 Adenocarcinoma Of Esophagus Digestive System Diseases; Neoplasms
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0399378 BXGD008242 Dentinogenesis imperfecta - Shield's type III (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1136382 BXGD011717 Sclerocystic Ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1258085 BXGD011822 Barrett Epithelium Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1839840 BXGD014417 MALE PSEUDOHERMAPHRODITISM: DEFICIENCY OF TESTICULAR 17,20-DESMOLASE Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2930618 BXGD017889 Intersex Conditions Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2930619 BXGD017890 Sex Differentiation Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2973527 BXGD018203 Dentinogenesis imperfecta without osteogenesis imperfecta Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C3151303 BXGD018415 Obesity, Hyperphagia, and Developmental Delay Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C3658266 BXGD019254 Prostatic Cancer, Castration-Resistant Neoplasms; Male Urogenital Diseases
C4022995 BXGD021056 Sex reversal
C4722419 BXGD023802 Extrapulmonary Small Cell Carcinoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000696 Tartaric acid 150.09
BXGC0001325 Progesterone 314.46
BXGC0001550 Ficus Latex peptide 2 244.26
BXGC0001857 Caffeic acid 180.16
BXGC0001889 p-Coumaric acid 164.16
BXGC0002867 Lappaurin 284.74
BXGC0002906 Caffeic acid ester 284.31
BXGC0006198 Citric acid 192.12
BXGC0008138 Jasmonic acid 210.27
BXGC0017757 Androstenedione 286.19
BXGC0020800 Testosterone 288.21
BXGC0022231 Ursodiol 392.29
BXGC0025368 2'-hydroxyflavone 238.06
BXGC0032375 Artepillin 300.17
BXGC0040667 Drupanin 232.11
BXGC0049447 acetate 59.01
BXGC0049738 Dexibuprofen 206.13
BXGC0052021 (R)-Ibuprophen 206.13
BXGC0052454 Baccharin 364.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein