acompound

Showing entry for Dexibuprofen

General Compound Information
BXGC Id	BXGC0049738
Compound Name	Dexibuprofen
Structure
Formula	C13H18O2
InchiKey	HEFNNWSXXWATRW-JTQLQIEISA-N
SMILES	CC(Cc1ccc(cc1)[C@@H](C(=O)O)C)C
Inchi	InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1
IUPAC	(2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid
Molecular Weight	206.13
Pubchem Id	39912
Chembl Id	CHEMBL175

Targets of Information Source

DrugBank

DB09213

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
P35354	BXGT009816	Prostaglandin G/H synthase 2	reviewed	Enzyme	PTGS2	approved; investigational	inhibitor
P23219	BXGT008837	Prostaglandin G/H synthase 1	reviewed	Enzyme	PTGS1	approved; investigational	inhibitor
P10415	BXGT007567	Apoptosis regulator Bcl-2	reviewed	Signaling	BCL2	approved; investigational	negative modulator
P07204	BXGT006567	Thrombomodulin	reviewed	-	THBD	approved; investigational	modulator
P00750	BXGT005642	Tissue-type plasminogen activator	reviewed	Enzyme	PLAT	approved; investigational	modulator
P12104	BXGT007773	Fatty acid-binding protein, intestinal	reviewed	-	FABP2	approved; investigational	binder
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	reviewed	Nuclear receptor	PPARG	approved; investigational	activator
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	reviewed	Ion channel	CFTR	approved; investigational	inhibitor
P46059	BXGT010500	Solute carrier family 15 member 1	reviewed	Transporter	SLC15A1	approved; investigational	-
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	reviewed	Nuclear receptor	PPARA	approved; investigational	-
P07359	BXGT006612	Platelet glycoprotein Ib alpha chain	reviewed	Receptor	GP1BA	approved; investigational	-
P31151	BXGT009510	Protein S100-A7	reviewed	Calcium-binding protein	S100A7	approved; investigational	-

PDB

IBP

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
P05979	BXGT006400	Prostaglandin G/H synthase 1	reviewed	PTGS1	-	-	-	-	-
P02768	BXGT005955	Serum albumin	reviewed	ALB	Transporter	-	-	-	-
P59071	BXGT011259	Basic phospholipase A2 VRV-PL-VIIIa	reviewed		-	-	-	-	-
Q08AH3	BXGT013015	Acyl-coenzyme A synthetase ACSM2A, mitochondrial	reviewed	ACSM2A	Enzyme	-	-	-	-
P24627	BXGT008981	Lactotransferrin	reviewed	LTF	-	-	-	480000	-
P15090	BXGT008079	Fatty acid-binding protein, adipocyte	reviewed	FABP4	-	-	-	-	-
P52895	BXGT010961	Aldo-keto reductase family 1 member C2	reviewed	AKR1C2	Enzyme	-	-	-	-
Q05769	BXGT012834	Prostaglandin G/H synthase 2	reviewed	Ptgs2	-	-	-	-	-
Q05320	BXGT012812	Envelope glycoprotein	reviewed	GP	-	-	-	-	-
P35747	BXGT009862	Serum albumin	reviewed	ALB	-	-	-	-	-

Binding DB

50169047

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT011342	Cell division control protein 42 homolog	reviewed	Enzyme modulator	CDC42	-	-	-	6412
reviewed	BXGT011342	Cell division control protein 42 homolog	reviewed	Enzyme modulator	CDC42	990	-	-	-
reviewed	BXGT011342	Cell division control protein 42 homolog	reviewed	Enzyme modulator	CDC42	-	-	-	16596
reviewed	BXGT011342	Cell division control protein 42 homolog	reviewed	Enzyme modulator	CDC42	3510	-	-	-
reviewed	BXGT008372	Ras-related protein Rab-7a	reviewed		RAB7A	-	-	-	4775
reviewed	BXGT008372	Ras-related protein Rab-7a	reviewed		RAB7A	310	-	-	-
reviewed	BXGT011482	Ras-related C3 botulinum toxin substrate 1	reviewed		Rac1	-	-	-	30000
reviewed	BXGT011359	Ras-related protein Rab-2A	reviewed		RAB2A	-	-	-	30000
reviewed	BXGT006400	Prostaglandin G/H synthase 1	reviewed		PTGS1	-	2260	-	-
reviewed	BXGT008837	Prostaglandin G/H synthase 1	reviewed	Enzyme	PTGS1	-	2600	-	-
reviewed	BXGT008837	Prostaglandin G/H synthase 1	reviewed	Enzyme	PTGS1	-	99	-	-
reviewed	BXGT011858	Prostaglandin G/H synthase 2	reviewed		PTGS2	-	265500	-	-
reviewed	BXGT011858	Prostaglandin G/H synthase 2	reviewed		PTGS2	-	1500	-	-
reviewed	BXGT006400	Prostaglandin G/H synthase 1	reviewed		PTGS1	-	3200	-	-
reviewed	BXGT008837	Prostaglandin G/H synthase 1	reviewed	Enzyme	PTGS1	-	1480	-	-
reviewed	BXGT009816	Prostaglandin G/H synthase 2	reviewed	Enzyme	PTGS2	-	730	-	-
reviewed	BXGT008313	Aldo-keto reductase family 1 member C4	reviewed	Enzyme	AKR1C4	-	>100000	-	-
reviewed	BXGT012787	Aldo-keto reductase family 1 member C1	reviewed	Enzyme	AKR1C1	-	>100000	-	-
reviewed	BXGT010961	Aldo-keto reductase family 1 member C2	reviewed	Enzyme	AKR1C2	-	42400	-	-
reviewed	BXGT010301	Aldo-keto reductase family 1 member C3	reviewed	Enzyme	AKR1C3	-	32700	-	-

CHEMBL

CHEMBL175

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P35354	BXGT009816	Prostaglandin G/H synthase 2	reviewed	Enzyme	PTGS2	IC50	'='	730	nM
P15127	BXGT008085	Insulin receptor	reviewed	-	Insr	IC50	-	-	-
P83916	BXGT012025	Chromobox protein homolog 1	reviewed	Epigenetic regulator	CBX1	Potency	-	79432	nM
P29477	BXGT009355	Nitric oxide synthase, inducible	reviewed	-	Nos2	Ki	-	-	-
P06239	BXGT006427	Tyrosine-protein kinase Lck	reviewed	Kinase	LCK	Ki	-	-	-
P08912	BXGT006840	Muscarinic acetylcholine receptor M5	reviewed	G-protein coupled receptor	CHRM5	Ki	-	-	-
Q05769	BXGT012834	Prostaglandin G/H synthase 2	reviewed	-	Ptgs2	Inhibition	'>'	99	%
P22437	BXGT008766	Prostaglandin G/H synthase 1	reviewed	-	Ptgs1	Inhibition	'>'	99	%
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	AC50	-	-	-
P43140	BXGT010360	Alpha-1A adrenergic receptor	reviewed	-	Adra1a	IC50	-	-	-
P15823	BXGT008160	Alpha-1B adrenergic receptor	reviewed	-	Adra1b	IC50	-	-	-
P25100	BXGT009017	Alpha-1D adrenergic receptor	reviewed	G-protein coupled receptor	ADRA1D	Ki	-	-	-
P08588	BXGT006795	Beta-1 adrenergic receptor	reviewed	G-protein coupled receptor	ADRB1	Ki	-	-	-
P32238	BXGT009611	Cholecystokinin receptor type A	reviewed	G-protein coupled receptor	CCKAR	IC50	-	-	-
P22303	BXGT008751	Acetylcholinesterase	reviewed	Enzyme	ACHE	IC50	-	-	-
P18825	BXGT008426	Alpha-2C adrenergic receptor	reviewed	G-protein coupled receptor	ADRA2C	Ki	-	-	-
P07550	BXGT006636	Beta-2 adrenergic receptor	reviewed	G-protein coupled receptor	ADRB2	IC50	-	-	-
P21554	BXGT008662	Cannabinoid receptor 1	reviewed	G-protein coupled receptor	CNR1	IC50	-	-	-
P21554	BXGT008662	Cannabinoid receptor 1	reviewed	G-protein coupled receptor	CNR1	Ki	-	-	-
P41597	BXGT010268	C-C chemokine receptor type 2	reviewed	-	CCR2	IC50	-	-	-
P35354	BXGT009816	Prostaglandin G/H synthase 2	reviewed	Enzyme	PTGS2	IC50	-	-	-
P11509	BXGT007716	Cytochrome P450 2A6	reviewed	-	CYP2A6	IC50	-	-	-
P21728	BXGT008686	D(1A) dopamine receptor	reviewed	G-protein coupled receptor	DRD1	Ki	-	-	-
P14416	BXGT008011	D(2) dopamine receptor	reviewed	G-protein coupled receptor	DRD2	Ki	-	-	-
P06241	BXGT006429	Tyrosine-protein kinase Fyn	reviewed	Kinase	FYN	Ki	-	-	-
P37288	BXGT009977	Vasopressin V1a receptor	reviewed	G-protein coupled receptor	AVPR1A	Ki	-	-	-
P08311	BXGT006762	Cathepsin G	reviewed	Enzyme	CTSG	IC50	-	-	-
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	reviewed	Kinase	ERBB2	IC50	-	-	-
P28335	BXGT009255	5-hydroxytryptamine receptor 2C	reviewed	G-protein coupled receptor	HTR2C	Ki	-	-	-
P25101	BXGT009018	Endothelin-1 receptor	reviewed	G-protein coupled receptor	EDNRA	IC50	-	-	-
P41968	BXGT010275	Melanocortin receptor 3	reviewed	G-protein coupled receptor	MC3R	Ki	-	-	-
P08173	BXGT006738	Muscarinic acetylcholine receptor M4	reviewed	G-protein coupled receptor	CHRM4	IC50	-	-	-
P49146	BXGT010681	Neuropeptide Y receptor type 2	reviewed	G-protein coupled receptor	NPY2R	Ki	-	-	-
Q99720	BXGT019955	Sigma non-opioid intracellular receptor 1	reviewed	-	SIGMAR1	Ki	-	-	-
P21452	BXGT008653	Substance-K receptor	reviewed	G-protein coupled receptor	TACR2	Ki	-	-	-
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	reviewed	Kinase	FLT1	Ki	-	-	-
O70528	BXGT005068	5-hydroxytryptamine receptor 4	reviewed	-	HTR4	Ki	-	-	-
P25103	BXGT009020	Substance-P receptor	reviewed	G-protein coupled receptor	TACR1	Ki	-	-	-
P08575	BXGT006793	Receptor-type tyrosine-protein phosphatase C	reviewed	Enzyme	PTPRC	IC50	-	-	-
P30542	BXGT009436	Adenosine receptor A1	reviewed	G-protein coupled receptor	ADORA1	Ki	-	-	-
P08913	BXGT006841	Alpha-2A adrenergic receptor	reviewed	G-protein coupled receptor	ADRA2A	Ki	-	-	-
Q92731	BXGT019366	Estrogen receptor beta	reviewed	Nuclear receptor	ESR2	IC50	-	-	-
P32245	BXGT009614	Melanocortin receptor 4	reviewed	G-protein coupled receptor	MC4R	Ki	-	-	-
P55926	BXGT011134	Acid-sensing ion channel 1	reviewed	-	Asic1	Inhibition	-	-	-
O15648	BXGT004185	ATP-dependent 6-phosphofructokinase	reviewed	-	pfk	Potency	-	1901	nM
P05979	BXGT006400	Prostaglandin G/H synthase 1	reviewed	-	PTGS1	IC50	'='	1480	nM
P25101	BXGT009018	Endothelin-1 receptor	reviewed	G-protein coupled receptor	EDNRA	Ki	-	-	-
Q690N0	BXGT016199	Progesterone receptor	unreviewed	-	PGR	IC50	-	-	-
P28482	BXGT009263	Mitogen-activated protein kinase 1	reviewed	Kinase	MAPK1	Ki	-	-	-
P10635	BXGT007595	Cytochrome P450 2D6	reviewed	-	CYP2D6	AC50	-	-	-
P0DMS8	BXGT007506	Adenosine receptor A3	reviewed	G-protein coupled receptor	ADORA3	Ki	-	-	-
P25100	BXGT009017	Alpha-1D adrenergic receptor	reviewed	G-protein coupled receptor	ADRA1D	IC50	-	-	-
P18089	BXGT008379	Alpha-2B adrenergic receptor	reviewed	G-protein coupled receptor	ADRA2B	IC50	-	-	-
P18089	BXGT008379	Alpha-2B adrenergic receptor	reviewed	G-protein coupled receptor	ADRA2B	Ki	-	-	-
P13945	BXGT007972	Beta-3 adrenergic receptor	reviewed	G-protein coupled receptor	ADRB3	Ki	-	-	-
P00918	BXGT005690	Carbonic anhydrase 2	reviewed	-	CA2	IC50	-	-	-
P25024	BXGT009005	C-X-C chemokine receptor type 1	reviewed	G-protein coupled receptor	CXCR1	IC50	-	-	-
P23219	BXGT008837	Prostaglandin G/H synthase 1	reviewed	Enzyme	PTGS1	Ki	-	-	-
P42330	BXGT010301	Aldo-keto reductase family 1 member C3	reviewed	Enzyme	AKR1C3	IC50	'='	32700	nM
P05979	BXGT006400	Prostaglandin G/H synthase 1	reviewed	-	PTGS1	IC50	'='	2260	nM
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	Potency	'='	31622	nM
P24557	BXGT008976	Thromboxane-A synthase	reviewed	-	TBXAS1	IC50	-	-	-
A6XA80	BXGT001522	Leukotriene C4 synthase	reviewed	-	LTC4S	Ki	-	-	-
P29476	BXGT009354	Nitric oxide synthase, brain	reviewed	-	Nos1	Ki	-	-	-
P29477	BXGT009355	Nitric oxide synthase, inducible	reviewed	-	Nos2	IC50	-	-	-
P29476	BXGT009354	Nitric oxide synthase, brain	reviewed	-	Nos1	IC50	-	-	-
P28564	BXGT009272	5-hydroxytryptamine receptor 1B	reviewed	-	Htr1b	Ki	-	-	-
P24557	BXGT008976	Thromboxane-A synthase	reviewed	-	TBXAS1	Ki	-	-	-
P25024	BXGT009005	C-X-C chemokine receptor type 1	reviewed	G-protein coupled receptor	CXCR1	Inhibition	'='	34	%
P25025	BXGT009006	C-X-C chemokine receptor type 2	reviewed	G-protein coupled receptor	CXCR2	Inhibition	'='	34	%
P04150	BXGT006154	Glucocorticoid receptor	reviewed	Nuclear receptor	NR3C1	IC50	-	-	-
Q9Y271	BXGT022222	Cysteinyl leukotriene receptor 1	reviewed	G-protein coupled receptor	CYSLTR1	IC50	-	-	-
P08172	BXGT006737	Muscarinic acetylcholine receptor M2	reviewed	G-protein coupled receptor	CHRM2	Ki	-	-	-
P41145	BXGT010225	Kappa-type opioid receptor	reviewed	G-protein coupled receptor	OPRK1	IC50	-	-	-
P41595	BXGT010267	5-hydroxytryptamine receptor 2B	reviewed	G-protein coupled receptor	HTR2B	IC50	-	-	-
P25103	BXGT009020	Substance-P receptor	reviewed	G-protein coupled receptor	TACR1	IC50	-	-	-
P32241	BXGT009613	Vasoactive intestinal polypeptide receptor 1	reviewed	G-protein coupled receptor	VIPR1	IC50	-	-	-
P23975	BXGT008935	Sodium-dependent noradrenaline transporter	reviewed	Transporter	SLC6A2	Ki	-	-	-
P50052	BXGT010768	Type-2 angiotensin II receptor	reviewed	G-protein coupled receptor	AGTR2	IC50	-	-	-
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	IC50	-	-	-
P04035	BXGT006129	3-hydroxy-3-methylglutaryl-coenzyme A reductase	reviewed	-	HMGCR	Ki	-	-	-
P23975	BXGT008935	Sodium-dependent noradrenaline transporter	reviewed	Transporter	SLC6A2	IC50	-	-	-
P04150	BXGT006154	Glucocorticoid receptor	reviewed	Nuclear receptor	NR3C1	Ki	-	-	-
P33261	BXGT009707	Cytochrome P450 2C19	reviewed	-	CYP2C19	AC50	-	-	-
P20781	BXGT008598	Glycine receptor subunit beta	reviewed	-	Glrb	Ki	-	-	-
P07727	BXGT006662	Glycine receptor subunit alpha-1	reviewed	-	Glra1	Ki	-	-	-
P24524	BXGT008974	Glycine receptor subunit alpha-3	reviewed	-	Glra3	Ki	-	-	-
P22771	BXGT008806	Glycine receptor subunit alpha-2	reviewed	-	Glra2	Ki	-	-	-
P25105	BXGT009021	Platelet-activating factor receptor	reviewed	G-protein coupled receptor	PTAFR	Ki	-	-	-
P12822	BXGT007850	Angiotensin-converting enzyme	reviewed	-	ACE	IC50	-	-	-
Q08209	BXGT012968	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	reviewed	-	PPP3CA	IC50	-	-	-
P03956	BXGT006120	Interstitial collagenase	reviewed	Enzyme	MMP1	IC50	-	-	-
P05979	BXGT006400	Prostaglandin G/H synthase 1	reviewed	-	PTGS1	Inhibition	-	-	-
P13945	BXGT007972	Beta-3 adrenergic receptor	reviewed	G-protein coupled receptor	ADRB3	IC50	-	-	-
P07943	BXGT006700	Aldo-keto reductase family 1 member B1	reviewed	-	Akr1b1	IC50	-	-	-
P07943	BXGT006700	Aldo-keto reductase family 1 member B1	reviewed	-	Akr1b1	Ki	-	-	-
P30988	BXGT009491	Calcitonin receptor	reviewed	G-protein coupled receptor	CALCR	IC50	-	-	-
P51679	BXGT010877	C-C chemokine receptor type 4	reviewed	G-protein coupled receptor	CCR4	Ki	-	-	-
P25025	BXGT009006	C-X-C chemokine receptor type 2	reviewed	G-protein coupled receptor	CXCR2	Ki	-	-	-
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	Ki	-	-	-
P18825	BXGT008426	Alpha-2C adrenergic receptor	reviewed	G-protein coupled receptor	ADRA2C	IC50	-	-	-
P25021	BXGT009004	Histamine H2 receptor	reviewed	G-protein coupled receptor	HRH2	Ki	-	-	-
P04035	BXGT006129	3-hydroxy-3-methylglutaryl-coenzyme A reductase	reviewed	-	HMGCR	IC50	-	-	-
P12530	BXGT007827	Arachidonate 15-lipoxygenase	reviewed	-	ALOX15	IC50	-	-	-
P33032	BXGT009689	Melanocortin receptor 5	reviewed	G-protein coupled receptor	MC5R	Ki	-	-	-
P37288	BXGT009977	Vasopressin V1a receptor	reviewed	G-protein coupled receptor	AVPR1A	IC50	-	-	-
P33032	BXGT009689	Melanocortin receptor 5	reviewed	G-protein coupled receptor	MC5R	IC50	-	-	-
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	AC50	-	-	-
P14780	BXGT008053	Matrix metalloproteinase-9	reviewed	Enzyme	MMP9	Ki	-	-	-
P08575	BXGT006793	Receptor-type tyrosine-protein phosphatase C	reviewed	Enzyme	PTPRC	Ki	-	-	-
P25105	BXGT009021	Platelet-activating factor receptor	reviewed	G-protein coupled receptor	PTAFR	IC50	-	-	-
P17252	BXGT008294	Protein kinase C alpha type	reviewed	Kinase	PRKCA	IC50	-	-	-
P27361	BXGT009176	Mitogen-activated protein kinase 3	reviewed	Kinase	MAPK3	Ki	-	-	-
P06241	BXGT006429	Tyrosine-protein kinase Fyn	reviewed	Kinase	FYN	IC50	-	-	-
P79208	BXGT011858	Prostaglandin G/H synthase 2	reviewed	-	PTGS2	IC50	'='	1500	nM
Q01453	BXGT012588	Peripheral myelin protein 22	reviewed	Cellular structure	PMP22	Potency	'='	84921	nM
P02545	BXGT005889	Prelamin-A/C	reviewed	-	LMNA	Potency	'='	2511	nM
P05979	BXGT006400	Prostaglandin G/H synthase 1	reviewed	-	PTGS1	IC50	'='	3200	nM
P35354	BXGT009816	Prostaglandin G/H synthase 2	reviewed	Enzyme	PTGS2	Inhibition	-	-	-
P03372	BXGT006059	Estrogen receptor	reviewed	Nuclear receptor	ESR1	IC50	-	-	-
P21397	BXGT008644	Amine oxidase [flavin-containing] A	reviewed	-	MAOA	Ki	-	-	-
P25929	BXGT009078	Neuropeptide Y receptor type 1	reviewed	G-protein coupled receptor	NPY1R	Ki	-	-	-
P49146	BXGT010681	Neuropeptide Y receptor type 2	reviewed	G-protein coupled receptor	NPY2R	IC50	-	-	-
P79208	BXGT011858	Prostaglandin G/H synthase 2	reviewed	-	PTGS2	IC50	'='	265500	nM
P35503	BXGT009840	UDP-glucuronosyltransferase 1-3	reviewed	-	UGT1A3	Activity	'='	83	pm/min/mg
Q9Y271	BXGT022222	Cysteinyl leukotriene receptor 1	reviewed	G-protein coupled receptor	CYSLTR1	Ki	-	-	-
P12530	BXGT007827	Arachidonate 15-lipoxygenase	reviewed	-	ALOX15	Ki	-	-	-
P20309	BXGT008562	Muscarinic acetylcholine receptor M3	reviewed	G-protein coupled receptor	CHRM3	IC50	-	-	-
P08173	BXGT006738	Muscarinic acetylcholine receptor M4	reviewed	G-protein coupled receptor	CHRM4	Ki	-	-	-
P54132	BXGT011032	Bloom syndrome protein	reviewed	-	BLM	Potency	'='	2	nM
Q92731	BXGT019366	Estrogen receptor beta	reviewed	Nuclear receptor	ESR2	Ki	-	-	-
P23219	BXGT008837	Prostaglandin G/H synthase 1	reviewed	Enzyme	PTGS1	Selectivity	'='	117	-
P35354	BXGT009816	Prostaglandin G/H synthase 2	reviewed	Enzyme	PTGS2	Selectivity	'='	117	-
P30411	BXGT009424	B2 bradykinin receptor	reviewed	G-protein coupled receptor	BDKRB2	Ki	-	-	-
P00918	BXGT005690	Carbonic anhydrase 2	reviewed	-	CA2	Ki	-	-	-
P41597	BXGT010268	C-C chemokine receptor type 2	reviewed	-	CCR2	Ki	-	-	-
P51681	BXGT010878	C-C chemokine receptor type 5	reviewed	G-protein coupled receptor	CCR5	Ki	-	-	-
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	Ki	-	-	-
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	Ki	-	-	-
P21728	BXGT008686	D(1A) dopamine receptor	reviewed	G-protein coupled receptor	DRD1	IC50	-	-	-
Q01959	BXGT012624	Sodium-dependent dopamine transporter	reviewed	Transporter	SLC6A3	IC50	-	-	-
P41143	BXGT010223	Delta-type opioid receptor	reviewed	G-protein coupled receptor	OPRD1	Ki	-	-	-
P25021	BXGT009004	Histamine H2 receptor	reviewed	G-protein coupled receptor	HRH2	IC50	-	-	-
A6XA80	BXGT001522	Leukotriene C4 synthase	reviewed	-	LTC4S	IC50	-	-	-
P29274	BXGT009327	Adenosine receptor A2a	reviewed	G-protein coupled receptor	ADORA2A	IC50	-	-	-
P43140	BXGT010360	Alpha-1A adrenergic receptor	reviewed	-	Adra1a	Ki	-	-	-
P50052	BXGT010768	Type-2 angiotensin II receptor	reviewed	G-protein coupled receptor	AGTR2	Ki	-	-	-
P30411	BXGT009424	B2 bradykinin receptor	reviewed	G-protein coupled receptor	BDKRB2	IC50	-	-	-
P25024	BXGT009005	C-X-C chemokine receptor type 1	reviewed	G-protein coupled receptor	CXCR1	Ki	-	-	-
P25025	BXGT009006	C-X-C chemokine receptor type 2	reviewed	G-protein coupled receptor	CXCR2	IC50	-	-	-
P23219	BXGT008837	Prostaglandin G/H synthase 1	reviewed	Enzyme	PTGS1	IC50	'='	98	nM
P49798	BXGT010745	Regulator of G-protein signaling 4	reviewed	Enzyme modulator	RGS4	Potency	-	946	nM
P15127	BXGT008085	Insulin receptor	reviewed	-	Insr	Ki	-	-	-
P35372	BXGT009823	Mu-type opioid receptor	reviewed	G-protein coupled receptor	OPRM1	IC50	-	-	-
P27361	BXGT009176	Mitogen-activated protein kinase 3	reviewed	Kinase	MAPK3	IC50	-	-	-
Q08209	BXGT012968	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	reviewed	-	PPP3CA	Ki	-	-	-
P19327	BXGT008472	5-hydroxytryptamine receptor 1A	reviewed	-	Htr1a	Ki	-	-	-
P28564	BXGT009272	5-hydroxytryptamine receptor 1B	reviewed	-	Htr1b	IC50	-	-	-
P50406	BXGT010796	5-hydroxytryptamine receptor 6	reviewed	G-protein coupled receptor	HTR6	Ki	-	-	-
P21397	BXGT008644	Amine oxidase [flavin-containing] A	reviewed	-	MAOA	IC50	-	-	-
P35372	BXGT009823	Mu-type opioid receptor	reviewed	G-protein coupled receptor	OPRM1	Ki	-	-	-
P14780	BXGT008053	Matrix metalloproteinase-9	reviewed	Enzyme	MMP9	IC50	-	-	-
P00533	BXGT005575	Epidermal growth factor receptor	reviewed	Kinase	EGFR	IC50	-	-	-
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	IC50	-	-	-
Q96KQ7	BXGT019687	Histone-lysine N-methyltransferase EHMT2	reviewed	Epigenetic regulator	EHMT2	Potency	-	0	nM
Q12809	BXGT013267	Potassium voltage-gated channel subfamily H member 2	reviewed	Ion channel	KCNH2	IC50	-	-	-
P12822	BXGT007850	Angiotensin-converting enzyme	reviewed	-	ACE	Ki	-	-	-
P50406	BXGT010796	5-hydroxytryptamine receptor 6	reviewed	G-protein coupled receptor	HTR6	IC50	-	-	-
Q01959	BXGT012624	Sodium-dependent dopamine transporter	reviewed	Transporter	SLC6A3	Ki	-	-	-
P30542	BXGT009436	Adenosine receptor A1	reviewed	G-protein coupled receptor	ADORA1	IC50	-	-	-
P30988	BXGT009491	Calcitonin receptor	reviewed	G-protein coupled receptor	CALCR	Ki	-	-	-
P51679	BXGT010877	C-C chemokine receptor type 4	reviewed	G-protein coupled receptor	CCR4	IC50	-	-	-
P23219	BXGT008837	Prostaglandin G/H synthase 1	reviewed	Enzyme	PTGS1	IC50	'='	105	nM
P37136	BXGT009967	Acetylcholinesterase	reviewed	-	Ache	Inhibition	'='	20	%
Q12809	BXGT013267	Potassium voltage-gated channel subfamily H member 2	reviewed	Ion channel	KCNH2	Ki	-	-	-
Q690N0	BXGT016199	Progesterone receptor	unreviewed	-	PGR	Ki	-	-	-
P03956	BXGT006120	Interstitial collagenase	reviewed	Enzyme	MMP1	Ki	-	-	-
P32241	BXGT009613	Vasoactive intestinal polypeptide receptor 1	reviewed	G-protein coupled receptor	VIPR1	Ki	-	-	-
P25024	BXGT009005	C-X-C chemokine receptor type 1	reviewed	G-protein coupled receptor	CXCR1	IC50	'='	100	nM
P25025	BXGT009006	C-X-C chemokine receptor type 2	reviewed	G-protein coupled receptor	CXCR2	IC50	'='	100	nM
P23219	BXGT008837	Prostaglandin G/H synthase 1	reviewed	Enzyme	PTGS1	IC50	'='	2600	nM
P19327	BXGT008472	5-hydroxytryptamine receptor 1A	reviewed	-	Htr1a	IC50	-	-	-
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	reviewed	G-protein coupled receptor	HTR2A	Ki	-	-	-
P31645	BXGT009558	Sodium-dependent serotonin transporter	reviewed	Transporter	SLC6A4	Ki	-	-	-
P23219	BXGT008837	Prostaglandin G/H synthase 1	reviewed	Enzyme	PTGS1	Inhibition	'='	29	%
P52895	BXGT010961	Aldo-keto reductase family 1 member C2	reviewed	Enzyme	AKR1C2	IC50	'='	42400	nM
P03372	BXGT006059	Estrogen receptor	reviewed	Nuclear receptor	ESR1	Ki	-	-	-
P20781	BXGT008598	Glycine receptor subunit beta	reviewed	-	Glrb	IC50	-	-	-
P07727	BXGT006662	Glycine receptor subunit alpha-1	reviewed	-	Glra1	IC50	-	-	-
P24524	BXGT008974	Glycine receptor subunit alpha-3	reviewed	-	Glra3	IC50	-	-	-
P22771	BXGT008806	Glycine receptor subunit alpha-2	reviewed	-	Glra2	IC50	-	-	-
P22303	BXGT008751	Acetylcholinesterase	reviewed	Enzyme	ACHE	Ki	-	-	-
P08913	BXGT006841	Alpha-2A adrenergic receptor	reviewed	G-protein coupled receptor	ADRA2A	IC50	-	-	-
P07550	BXGT006636	Beta-2 adrenergic receptor	reviewed	G-protein coupled receptor	ADRB2	Ki	-	-	-
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	IC50	-	-	-
P33261	BXGT009707	Cytochrome P450 2C19	reviewed	-	CYP2C19	IC50	-	-	-
P23219	BXGT008837	Prostaglandin G/H synthase 1	reviewed	Enzyme	PTGS1	Inhibition	'='	90	%
P21452	BXGT008653	Substance-K receptor	reviewed	G-protein coupled receptor	TACR2	IC50	-	-	-
P15207	BXGT008096	Androgen receptor	reviewed	-	Ar	IC50	-	-	-
P29466	BXGT009349	Caspase-1	reviewed	Enzyme	CASP1	IC50	-	-	-
P08246	BXGT006756	Neutrophil elastase	reviewed	Enzyme	ELANE	IC50	-	-	-
Q16539	BXGT013634	Mitogen-activated protein kinase 14	reviewed	Kinase	MAPK14	Ki	-	-	-
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	AC50	'='	39810	nM
Q13148	BXGT013318	TAR DNA-binding protein 43	reviewed	-	TARDBP	Potency	-	25118	nM
Q194T2	BXGT013743	Non-structural protein 1	unreviewed	-	NS1	Potency	'='	22387	nM
P21917	BXGT008707	D(4) dopamine receptor	reviewed	G-protein coupled receptor	DRD4	IC50	-	-	-
P21917	BXGT008707	D(4) dopamine receptor	reviewed	G-protein coupled receptor	DRD4	Ki	-	-	-
P28335	BXGT009255	5-hydroxytryptamine receptor 2C	reviewed	G-protein coupled receptor	HTR2C	IC50	-	-	-
P33261	BXGT009707	Cytochrome P450 2C19	reviewed	-	CYP2C19	Ki	-	-	-
P35462	BXGT009835	D(3) dopamine receptor	reviewed	G-protein coupled receptor	DRD3	IC50	-	-	-
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	Potency	'='	39810	nM
P16473	BXGT008234	Thyrotropin receptor	reviewed	G-protein coupled receptor	TSHR	Potency	'='	2511	nM
P29274	BXGT009327	Adenosine receptor A2a	reviewed	G-protein coupled receptor	ADORA2A	Ki	-	-	-
P11509	BXGT007716	Cytochrome P450 2A6	reviewed	-	CYP2A6	Ki	-	-	-
P17516	BXGT008313	Aldo-keto reductase family 1 member C4	reviewed	Enzyme	AKR1C4	IC50	'>'	100000	nM
P29466	BXGT009349	Caspase-1	reviewed	Enzyme	CASP1	Ki	-	-	-
P28482	BXGT009263	Mitogen-activated protein kinase 1	reviewed	Kinase	MAPK1	IC50	-	-	-
O76074	BXGT005174	cGMP-specific 3',5'-cyclic phosphodiesterase	reviewed	-	PDE5A	IC50	-	-	-
O76074	BXGT005174	cGMP-specific 3',5'-cyclic phosphodiesterase	reviewed	-	PDE5A	Ki	-	-	-
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	reviewed	Kinase	FLT1	IC50	-	-	-
P32238	BXGT009611	Cholecystokinin receptor type A	reviewed	G-protein coupled receptor	CCKAR	Ki	-	-	-
P14416	BXGT008011	D(2) dopamine receptor	reviewed	G-protein coupled receptor	DRD2	IC50	-	-	-
P15823	BXGT008160	Alpha-1B adrenergic receptor	reviewed	-	Adra1b	Ki	-	-	-
Q13951	BXGT013407	Core-binding factor subunit beta	reviewed	-	CBFB	Potency	-	7943	nM
Q01196	BXGT012575	Runt-related transcription factor 1	reviewed	Transcription factor	RUNX1	Potency	-	7943	nM
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	reviewed	Kinase	ERBB2	Ki	-	-	-
P11229	BXGT007676	Muscarinic acetylcholine receptor M1	reviewed	G-protein coupled receptor	CHRM1	IC50	-	-	-
P08311	BXGT006762	Cathepsin G	reviewed	Enzyme	CTSG	Ki	-	-	-
Q16539	BXGT013634	Mitogen-activated protein kinase 14	reviewed	Kinase	MAPK14	IC50	-	-	-
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	reviewed	G-protein coupled receptor	HTR2A	IC50	-	-	-
P41595	BXGT010267	5-hydroxytryptamine receptor 2B	reviewed	G-protein coupled receptor	HTR2B	Ki	-	-	-
P00533	BXGT005575	Epidermal growth factor receptor	reviewed	Kinase	EGFR	Ki	-	-	-
P35367	BXGT009821	Histamine H1 receptor	reviewed	G-protein coupled receptor	HRH1	Ki	-	-	-
P08246	BXGT006756	Neutrophil elastase	reviewed	Enzyme	ELANE	Ki	-	-	-
P35354	BXGT009816	Prostaglandin G/H synthase 2	reviewed	Enzyme	PTGS2	Ki	-	-	-
P10635	BXGT007595	Cytochrome P450 2D6	reviewed	-	CYP2D6	IC50	-	-	-
P10635	BXGT007595	Cytochrome P450 2D6	reviewed	-	CYP2D6	Ki	-	-	-
P05181	BXGT006337	Cytochrome P450 2E1	reviewed	-	CYP2E1	IC50	-	-	-
P05181	BXGT006337	Cytochrome P450 2E1	reviewed	-	CYP2E1	Ki	-	-	-
P35462	BXGT009835	D(3) dopamine receptor	reviewed	G-protein coupled receptor	DRD3	Ki	-	-	-
O70528	BXGT005068	5-hydroxytryptamine receptor 4	reviewed	-	HTR4	IC50	-	-	-
P08588	BXGT006795	Beta-1 adrenergic receptor	reviewed	G-protein coupled receptor	ADRB1	IC50	-	-	-
P0DMS8	BXGT007506	Adenosine receptor A3	reviewed	G-protein coupled receptor	ADORA3	IC50	-	-	-
P51681	BXGT010878	C-C chemokine receptor type 5	reviewed	G-protein coupled receptor	CCR5	IC50	-	-	-
P15289	BXGT008102	Arylsulfatase A	reviewed	Enzyme	ARSA	Potency	-	151	nM
P11229	BXGT007676	Muscarinic acetylcholine receptor M1	reviewed	G-protein coupled receptor	CHRM1	Ki	-	-	-
P25929	BXGT009078	Neuropeptide Y receptor type 1	reviewed	G-protein coupled receptor	NPY1R	IC50	-	-	-
P41143	BXGT010223	Delta-type opioid receptor	reviewed	G-protein coupled receptor	OPRD1	IC50	-	-	-
P35367	BXGT009821	Histamine H1 receptor	reviewed	G-protein coupled receptor	HRH1	IC50	-	-	-
P41145	BXGT010225	Kappa-type opioid receptor	reviewed	G-protein coupled receptor	OPRK1	Ki	-	-	-
P55926	BXGT011134	Acid-sensing ion channel 1	reviewed	-	Asic1	Imax	'='	95	%
Q04828	BXGT012787	Aldo-keto reductase family 1 member C1	reviewed	Enzyme	AKR1C1	IC50	'>'	100000	nM
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	AC50	'='	15848	nM
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	Potency	'='	15848	nM
P08172	BXGT006737	Muscarinic acetylcholine receptor M2	reviewed	G-protein coupled receptor	CHRM2	IC50	-	-	-
P20309	BXGT008562	Muscarinic acetylcholine receptor M3	reviewed	G-protein coupled receptor	CHRM3	Ki	-	-	-
P0A6C1	BXGT007045	Endonuclease 4	reviewed	-	nfo	Potency	'='	251	nM
P32245	BXGT009614	Melanocortin receptor 4	reviewed	G-protein coupled receptor	MC4R	IC50	-	-	-
P31645	BXGT009558	Sodium-dependent serotonin transporter	reviewed	Transporter	SLC6A4	IC50	-	-	-
Q99720	BXGT019955	Sigma non-opioid intracellular receptor 1	reviewed	-	SIGMAR1	IC50	-	-	-
P15207	BXGT008096	Androgen receptor	reviewed	-	Ar	Ki	-	-	-
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	reviewed	-	APEX1	Potency	-	0	nM
P41968	BXGT010275	Melanocortin receptor 3	reviewed	G-protein coupled receptor	MC3R	IC50	-	-	-
P08912	BXGT006840	Muscarinic acetylcholine receptor M5	reviewed	G-protein coupled receptor	CHRM5	IC50	-	-	-
O35240	BXGT004519	Acid-sensing ion channel 3	reviewed	-	Asic3	IC50	'='	309029	nM
P17252	BXGT008294	Protein kinase C alpha type	reviewed	Kinase	PRKCA	Ki	-	-	-
P06239	BXGT006427	Tyrosine-protein kinase Lck	reviewed	Kinase	LCK	IC50	-	-	-
Q62962	BXGT016051	Acid-sensing ion channel 2	reviewed	-	Asic2	Imax	'='	55	%
O35240	BXGT004519	Acid-sensing ion channel 3	reviewed	-	Asic3	Imax	'='	85	%
P55926	BXGT011134	Acid-sensing ion channel 1	reviewed	-	Asic1	IC50	'='	346736	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00946	Artemisia montana	Artemisia montana	Medicinal Plant
BXGF03953	Artemisia princeps	Artemisia princeps	Medicinal Plant
BXGF04611	Artemisia argyi	Artemisia argyi	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}